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Translating Genomics in Cancer Care

Yvonne Bombard, Peter B. Bach, and Kenneth Offit

Examples: BRCA Testing for Breast and Ovarian Cancer Susceptibility: The report by the USP-STF considered the impact of genetic counseling on psychosocial response to BRCA testing (eg, anxiety, depression, cancer risk perception, uptake) and found

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NCCN Guidelines Insights: Prostate Cancer Early Detection, Version 2.2016

Peter R. Carroll, J. Kellogg Parsons, Gerald Andriole, Robert R. Bahnson, Erik P. Castle, William J. Catalona, Douglas M. Dahl, John W. Davis, Jonathan I. Epstein, Ruth B. Etzioni, Thomas Farrington, George P. Hemstreet III, Mark H. Kawachi, Simon Kim, Paul H. Lange, Kevin R. Loughlin, William Lowrance, Paul Maroni, James Mohler, Todd M. Morgan, Kelvin A. Moses, Robert B. Nadler, Michael Poch, Chuck Scales, Terrence M. Shaneyfelt, Marc C. Smaldone, Geoffrey Sonn, Preston Sprenkle, Andrew J. Vickers, Robert Wake, Dorothy A. Shead, and Deborah A. Freedman-Cass

-Risk Assessment: Breast and Ovarian. These latter guidelines include personalized risk assessment, genetic counseling, and possible genetic testing for individuals with a personal history of prostate cancer and 1 or more close blood relatives with breast cancer

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The Role of Radiation Therapy in the Treatment of Medullary Thyroid Cancer

Stephanie A. Terezakis and Nancy Y. Lee

the presence of MTC. Because MTC has high penetrance in all 3 familial forms, first-degree relatives of a family member with the mutation should receive genetic counseling and testing if the patient index demonstrates the RET mutation. 10 , 11 The

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Breast Cancer, Version 4.2017, NCCN Clinical Practice Guidelines in Oncology

William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon H. Giordano, Matthew P. Goetz, Lori J. Goldstein, Steven J. Isakoff, Janice Lyons, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena S. Moran, Ruth M. O'Regan, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Amy Sitapati, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda L. Telli, John H. Ward, Rashmi Kumar, and Dorothy A. Shead

and is not required. Genetic counseling is recommended if the patient is considered to be at high risk for hereditary breast cancer as defined by the NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast and Ovarian (available at NCCN

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Understanding Causes of Inferior Outcomes in Adolescents and Young Adults With Cancer

Julie A. Wolfson, Kelly M. Kenzik, Blake Foxworthy, John M. Salsman, Katherine Donahue, Marie Nelson, Mary Beth Littrell, Grant R. Williams, and Jennifer M. Levine

Pediatric Oncology and Hematology . Am J Med Genet A 2017 ; 173 : 1017 – 1037 . 44. Morand M , Roth M , Peterson SK , Factors impacting adolescent and young adult cancer patients’ decision to pursue genetic counseling and testing

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NCCN Guidelines Insights: Prostate Cancer, Version 1.2021

Featured Updates to the NCCN Guidelines

Edward Schaeffer, Sandy Srinivas, Emmanuel S. Antonarakis, Andrew J. Armstrong, Justin E. Bekelman, Heather Cheng, Anthony Victor D’Amico, Brian J. Davis, Neil Desai, Tanya Dorff, James A. Eastham, Thomas A. Farrington, Xin Gao, Eric Mark Horwitz, Joseph E. Ippolito, Michael R. Kuettel, Joshua M. Lang, Rana McKay, Jesse McKenney, George Netto, David F. Penson, Julio M. Pow-Sang, Robert Reiter, Sylvia Richey, Mack Roach, III, Stan Rosenfeld, Ahmad Shabsigh, Daniel E. Spratt, Benjamin A. Teply, Jonathan Tward, Dorothy A. Shead, and Deborah A. Freedman-Cass

tumor MSI-H or dMMR is identified, the panel recommends referral to genetic counseling for consideration of germline testing for Lynch syndrome. New Systemic Therapy Options for CRPC PARP Inhibitors for Patients With DNA Repair Gene Mutations Results of

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Abstracts From the NCCN 2024 Annual Conference

genetic testing were identified through the Ambry CARE Program and were offered pre-test education and a 36-gene panel test. Patients testing positive for a pathogenic or likely pathogenic (P/LP) variant were offered third-party genetic counseling. A

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Part 2: Abstracts from the NCCN 19th Annual Conference: Advancing the Standard of Cancer Care™

18% were referred to genetic counseling. Results are presented in Table 1 . Conclusions: The Athena model effectively identifies women previously unaware of their elevated breast cancer risk status. The findings support the value and efficiency of

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Invasive Breast Cancer Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J. Goldstein, Clifford A. Hudis, Steven J. Isakoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena Moran, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead, and Rashmi Kumar

reporting the pathologic analysis of all breast cancer specimens. Genetic Counseling: Genetic counselling is recommended for patients considered to be at high risk for hereditary breast cancer as defined by the NCCN Guidelines for Genetic/Familial High

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Breast Cancer Version 2.2015

William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J. Goldstein, Clifford A. Hudis, Steven J. Isakoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena Moran, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead, and Rashmi Kumar

.cap.org ). The NCCN Breast Cancer Panel endorses the use of the CAP protocols for reporting the pathologic analysis of all breast cancer specimens. Genetic Counseling For patients considered to be at high risk for hereditary breast cancer as defined by