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Healthcare Utilization and Costs During the Initial Phase of Care Among Elderly Women With Breast Cancer

Ami Vyas, S. Suresh Madhavan, Usha Sambamoorthi, Xiaoyun (Lucy) Pan, Michael Regier, Hannah Hazard, and Sita Kalidindi

, radiotherapy (RT), and adjuvant therapy. 2 – 6 Regardless of these extensive costs to Medicare, there is insufficient up-to-date information on healthcare utilization and costs incurred by specific services, and factors significantly contributing to these

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Routine Use of Zoledronic Acid in Early-Stage Breast Cancer

Kathleen Harnden and Kimberly Blackwell

recent prospective trial to date evaluating zoledronic acid in addition to standard adjuvant therapy in ESBC. 21 At the final efficacy analysis after a median follow-up Table 1 Characteristics of Published Phase III Trials With Zoledronic Acid

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Adolescent and Young Adult Colorectal Cancer

Joleen M. Hubbard and Axel Grothey

% of patients undergoing total colectomy will have 5 or more bowel movements per day, and 30% will have issues with fecal incontinence. 34 , 35 Adjuvant Therapy for Stage II and III Colon Cancer Patients with high-risk stage II and III disease

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Evolving Treatment Paradigm in the Treatment of Locally Advanced Rectal Cancer

Clayton A. Smith and Lisa A. Kachnic

improve 10-year OS compared with observation (51.8% vs 48.4%; P =.32). 13 Although early analysis demonstrated a DFS benefit of adjuvant therapy for patients with ypT0–2 (hazard ratio [HR], 0.64; 95% CI, 0.45–0.91; P =.13), this benefit was not observed

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Neoadjuvant Therapy for Rectal Cancer Affects Lymph Node Yield and Status Without Clear Implications on Outcome: The Case for Eliminating a Metric and Using Preoperative Staging to Guide Therapy

Sherif R. Z. Abdel-Misih, Lai Wei, Al B. Benson III, Steven Cohen, Lily Lai, John Skibber, Neal Wilkinson, Martin Weiser, Deborah Schrag, and Tanios Bekaii-Saab

the question as to the utility of the current standard of care, which is 6 months of perioperative systemic therapy. Given the unclear utility of adjuvant therapy after preoperative therapy has been administered, the clinical importance of pathologic

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Melanoma

Daniel G. Coit, Robert Andtbacka, Christopher K. Bichakjian, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi, Mohammed Kashani-Sabet, Julie R. Lange, Anne Lind, Lainie Martin, Mary C. Martini, Scott K. Pruitt, Merrick I. Ross, Stephen F. Sener, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, Marshall M. Urist, Jeffrey Weber, and Michael K. Wong

dissection for melanoma . J Clin Oncol 2004 ; 22 : 3677 – 3684 . 70 Cascinelli N Belli F MacKie RM . Effect of long-term adjuvant therapy with interferon alpha-2a in patients with regional node metastases from cutaneous melanoma: a randomised

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A Change of Heart

Crystal S. Denlinger

as adjuvant therapy for patients with node-positive, human epidermal growth factor receptor 2–positive breast cancer . J Clin Oncol 2012 ; 30 : 3792 – 3799 . 5. Bonneterre J Roché H Kerbrat P . Long-term cardiac follow-up in relapse

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Ten Years of Progress in Non–Small Cell Lung Cancer

David S. Ettinger

fusion gene EML-4 ALK . This mutation seems to be mutually exclusive with the EGFR and KRAS mutation in the phase I study. Adjuvant Therapy In 2004, the International Adjuvant Lung Cancer Trial showed an approximately 5% survival advantage

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Taxanes in the Adjuvant Treatment of Breast Cancer

Donna Trauth and Lori J. Goldstein

1998 ; 17 : 101 . 65 Eifel P Axelson JA Costa J . National Institutes of Health Consensus Development Conference Statement: Adjuvant therapy for breast cancer, November 1-3 2000 . J Natl Cancer Inst 2001 ; 93 : 979 . www

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Clinical Risk During the Evaluation of Genomic Risk for Hormone-Sensitive Breast Cancer: Ignoring Valuable Data

Ali Raza Khaki, V.K. Gadi, and Vinay Prasad

LA , Davis GJ , . Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer . J Clin Oncol 2001 ; 19 : 980 – 991 . 11181660 10.1200/JCO.2001.19.4.980 2. Wishart GC , Azzato EM , Greenberg