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Ami M. Vyas, Hilary Aroke, and Stephen J. Kogut

metastases) at 3.2%. Conclusion: Almost one quarter of the study cohort did not receive guideline-concordant care. There are opportunities to improve cancer care for women with negative HR status who have lower socioeconomic status. The high unexplained

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Robert W. Carlson, Elizabeth Brown, Harold J. Burstein, William J. Gradishar, Clifford A. Hudis, Charles Loprinzi, Eleftherios Paul Mamounas, Edith A. Perez, Kathleen Pritchard, Peter Ravdin, Abram Recht, George Somlo, Richard L. Theriault, Eric P. Winer, Antonio C. Wolff, and for the NCCN Adjuvant Therapy for Breast Cancer Task Force

. This training set outperformed all clinical variables in predicting the likelihood of distant metastases within 5 years in this group of women younger than 55 years of age and with lymph node–negative breast cancer. A subsequent validation study was

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Giuseppe Curigliano

Boston, MA, U.S.A.; Tuesday, 9.40 a.m. Patient: “Doctor, I am very worried about the CT scan report. It says ‘disease progression.’ ‘Progression’ means I have metastases, doesn’t it? How long will I live?” Milan, Italy; Tuesday, 11.00 a

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Jennifer Shih, Babar Bashir, Karen S. Gustafson, Mark Andrake, Roland L. Dunbrack, Lori J. Goldstein, and Yanis Boumber

2 ). Based on the morphology and immunohistochemical profile, a lung primary was favored. A staging PET/CT confirmed the CT findings of at least stage IIIb disease. A brain MRI unfortunately showed 2 small cerebral metastases in the right and left

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Owen Tan, Deborah J. Schofield, and Rupendra Shrestha

from a combination of pathology reports, inpatient notifications, and other treatment facilities. The variable was categorized as localized to tissue of origin, regional spread, adjacent organs and/or regional lymph nodes, distant metastases, and

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Fei Gao, Nan Li, YongMei Xu, and GuoWang Yang

-related mortality and can have a harmful effect on these patients, and was associated with a significant decrease in survival. For patients with <6 positive lymph node metastases who did not receive POCT, however, RT can improve survival time, and for patients with

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Vinayak Muralidhar, Paul L. Nguyen, Brandon A. Mahal, David D. Yang, Kent W. Mouw, Brent S. Rose, Clair J. Beard, Jason A. Efstathiou, Neil E. Martin, Martin T. King, and Peter F. Orio III

), and presence of distant metastases (M0 vs M1). Presence of nodal or distant metastases is recorded in the NCDB before treatment based on coding from patient medical records. The PSA cutoff of ≥98.0 ng/mL was chosen due to limitations in the NCDB: all

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Karolina Kata, Juan C. Rodriguez-Quintero, Octavio D. Arevalo, Jackie J. Zhang, Meenakshi Bidwai Bhattacharjee, Cornelius Ware, Antonio Dono, Roy Riascos-Castaneda, Nitin Tandon, Angel Blanco, Yoshua Esquenazi, Leomar Y. Ballester, Mark Amsbaugh, Arthur L. Day, and Jay-Jiguang Zhu

), and the patient developed LMD (arrowhead in H ) in October 2019. The LMD and parenchymal infiltrative PXA tumor showed a partial response to treatment, as shown in (K) . Findings from MRI October 2019 showed extracranial metastases in the spine (see

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Quisette P. Janssen, Jacob L. van Dam, Laura R. Prakash, Deesje Doppenberg, Christopher H. Crane, Casper H.J. van Eijck, Susannah G. Ellsworth, William R. Jarnagin, Eileen M. O’Reilly, Alessandro Paniccia, Marsha Reyngold, Marc G. Besselink, Matthew H.G. Katz, Ching-Wei D. Tzeng, Amer H. Zureikat, Bas Groot Koerkamp, Alice C. Wei, and for the Trans-Atlantic Pancreatic Surgery (TAPS) Consortium

, a patient who undergoes a resection might be diagnosed with liver metastases 3 months after surgery; in the RT group, the same patient would be diagnosed with liver metastases at restaging after RT and would therefore not end up in the resection

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Matthew D. Galsky, Harry W. Herr, and Dean F. Bajorin

Despite surgery with curative intent, approximately 50% of patients with muscle-invasive transitional cell carcinoma of the bladder will develop distant metastases and succumb to their disease. Attempts to improve outcomes have focused on refining surgical techniques and integrating perioperative chemotherapy. This review summarizes the available literature addressing the role of pelvic lymphadenectomy, neoadjuvant chemotherapy, and adjuvant chemotherapy in the management of patients with muscle-invasive transitional cell carcinoma of bladder.