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Breast Cancer Risk Reduction and Counseling: Lifestyle, Chemoprevention, and Surgery

Martin C. Mahoney

Qualitative and quantitative approaches to risk assessment are useful for identifying women at increased risk for developing breast cancer for whom genetics consultation, individualized surveillance recommendations, or chemoprevention may be appropriate. A comprehensive medical and family history review can be used to stratify women into categories of breast cancer risk. A quantitative estimate of the probability of developing breast cancer can be determined using risk assessment tools, such as the Gail and Claus models. Women at increased risk for breast cancer may benefit from individualized approaches to breast cancer risk reduction. Prevention strategies for reducing breast cancer risk include lifestyle modifications, chemoprevention, surgical approaches, and pharmacotherapy.

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Multidisciplinary Management of Locally Advanced Rectal Cancer: Neoadjuvant Approaches

Swaminathan Murugappan, William P. Harris, Christopher G. Willett, and Edward Lin

long-term outcomes in patients with resectable rectal cancer. 26 Table 1 Factors Affecting Local Recurrence After Surgery for Locally Advanced Rectal Cancer The Evolution of Current Treatment Strategies Increased rates of local

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Initial Management and Follow-up of Differentiated Thyroid Cancer in Children

Steven G. Waguespack and Gary Francis

of a palpable thyroid nodule. However, PTC also frequently presents as cervical adenopathy with or without a palpable thyroid lesion, or as an incidental finding after imaging or surgery for an unrelated condition. 26 Occasionally, it may be

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Local Therapies for Hepatic Metastases

Fabian M. Johnston, Michael N. Mavros, Joseph M. Herman, and Timothy M. Pawlik

situations, a 2-stage hepatectomy may be considered. 11 In general, a 2-stage approach involves an initial minor hepatectomy to remove the CRLM from one hemiliver (typically the left liver). The right portal vein is either ligated at the initial surgery or a

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Overuse of Diagnostic Brain Imaging Among Patients With Stage IA Non–Small Cell Lung Cancer

Michael G. Milligan, Angel M. Cronin, Yolonda Colson, Kenneth Kehl, Debra N. Yeboa, Deborah Schrag, and Aileen B. Chen

and Diagnosis Summary File to determine whether site-specific surgery was performed (a dichotomous variable) and to calculate the length of survival after cancer diagnosis. ICD-9 and CPT codes were used to identify interventions recorded in the

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Pregnancy Screening in Patients With Cancer

Annika M. Gustafson, Deborah J. Goldfrank, William A. Dunson, Daniel L. Mulkerin, Rebecca L. Caires, and Keith D. Eaton

. Prevention of adverse outcomes is the shared responsibility of patients, providers, and healthcare organizations. Background Cancer treatment modalities include chemotherapy, radiation, hormone therapy, and surgery, all of which can have adverse effects

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Current Concepts in the Evaluation and Treatment of Patients With Diffuse Malignant Peritoneal Mesothelioma

Keli Turner, Sheelu Varghese, and H. Richard Alexander

this natural history, operative strategies designed to control disease progression within the abdominal cavity have been developed and increasingly used over the past 20 years. Currently, cytoreductive surgery (CRS) together with hyperthermic

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Mortality After Invasive Second Breast Cancers Following Prior Radiotherapy for DCIS

Puyao C. Li, Zilu Zhang, Angel M. Cronin, and Rinaa S. Punglia

Background Women with a history of ductal carcinoma in situ (DCIS) are at increased risk for developing a second breast cancer (SBC) in either the ipsilateral or contralateral breast. 1 , 2 Many women receive breast-conserving surgery (BCS) with

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BPI24-011: Impact of Obesity on Sentinel Lymph Node Mapping in Patients With Endometrial Intraepithelial Neoplasia Undergoing Robotic Surgery

Tomer Bar Noy, Yossi Tzur, Yoav Brezinov, Emad Matanes, Susie Lau, Shannon Salvador, Melica Nourmoussavi Brodeur, and Walter Gotlieb

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Cost Implications and Complications of Overtreatment of Low-Risk Prostate Cancer in the United States

Ayal A. Aizer, Xiangmei Gu, Ming-Hui Chen, Toni K. Choueiri, Neil E. Martin, Jason A. Efstathiou, Andrew S. Hyatt, Powell L. Graham, Quoc-Dien Trinh, Jim C. Hu, and Paul L. Nguyen

surgery or radiation) are presented at the bottom of the figure. Vertical black lines represent the interquartile range. Each annual dollar amount was discounted to time zero. Abbreviations: AS, active surveillance; O, observation; WW, watchful waiting