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Peter G. Shields, Roy S. Herbst, Douglas Arenberg, Neal L. Benowitz, Laura Bierut, Julie Bylund Luckart, Paul Cinciripini, Bradley Collins, Sean David, James Davis, Brian Hitsman, Andrew Hyland, Margaret Lang, Scott Leischow, Elyse R. Park, W. Thomas Purcell, Jill Selzle, Andrea Silber, Sharon Spencer, Tawee Tanvetyanon, Brian Tiep, Hilary A. Tindle, Reginald Tucker-Seeley, James Urbanic, Monica Webb Hooper, Benny Weksler, C. Will Whitlock, Douglas E. Wood, Jennifer Burns, and Jillian Scavone

bladder cancer patients treated with radical cystectomy . Eur Urol 2013 ; 64 : 456 – 464 . 41. Ehdaie B Furberg H Zabor EC . Impact of smoking status at diagnosis on disease recurrence and death in upper tract urothelial carcinoma . BJU Int

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NCCN Guidelines Insights: Survivorship, Version 2.2020

Featured Updates to the NCCN Guidelines

Crystal S. Denlinger, Tara Sanft, Javid J. Moslehi, Linda Overholser, Saro Armenian, K. Scott Baker, Gregory Broderick, Wendy Demark-Wahnefried, Debra L. Friedman, Mindy Goldman, Norah Lynn Henry, Christine Hill-Kayser, Melissa Hudson, Nazanin Khakpour, Divya Koura, Allison L. McDonough, Michelle Melisko, Kathi Mooney, Halle C. F. Moore, Natalie Moryl, Tracey O’Connor, Electra D. Paskett, Chirayu Patel, Lindsay Peterson, William Pirl, M. Alma Rodriguez, Kathryn J. Ruddy, Lillie Shockney, Sophia Smith, Karen L. Syrjala, Amye Tevaarwerk, Phyllis Zee, Nicole R. McMillian, and Deborah A. Freedman-Cass

30% in survivors of small cell lung cancer. 51 Another study of >2 million cancer survivors in the SEER database identified bladder cancer survivors as having the highest risk for subsequent primary cancers (34% at 20 years). 52 Overall, this study

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Emily J. Guerard, Allison M. Deal, YunKyung Chang, Grant R. Williams, Kirsten A. Nyrop, Mackenzi Pergolotti, Hyman B. Muss, Hanna K. Sanoff, and Jennifer L. Lund

study . Crit Rev Oncol Hematol 2010 ; 76 : 208 – 217 . 33. Chappidi MR Kates M Patel HD . Frailty as a marker of adverse outcomes in patients with bladder cancer undergoing radical cystectomy . Urol Oncol 2016 ; 34 : 256.e1 – 6

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David Cella, Sarah K. Rosenbloom, Jennifer L. Beaumont, Susan E. Yount, Diane Paul, Debra Hampton, Amy P. Abernethy, Paul B. Jacobsen, Karen Syrjala, and Jamie H. Von Roenn

other primary malignancy diagnosed or treated within the previous 5 years, excluding nonmelanoma skin cancer. A total of 533 patients participated in the study, with approximately 50 patients per disease site except for bladder cancer (n = 31). Table 1

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Kavea Panneerselvam, Rajan N. Amin, Dongguang Wei, Dongfeng Tan, Phillip J. Lum, Hao Chi Zhang, David M. Richards, Mehmet Altan, Petros Grivas, John A. Thompson, Anusha S. Thomas, and Yinghong Wang

.1056/NEJMoa1503093 25891173 12. Powles T , Eder JP , Fine GD , MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer . Nature 2014 ; 515 : 558 – 562 . 25428503 10.1038/nature13904 13. Robert C , Thomas

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Dominik J. Ose, Richard Viskochil, Andreana N. Holowatyj, Mikaela Larson, Dalton Wilson, William A. Dunson Jr, Vikrant G. Deshmukh, J. Ryan Butcher, Belinda R. Taylor, Kim Svoboda, Jennifer Leiser, Benjamin Tingey, Benjamin Haaland, David W. Wetter, Simon J. Fisher, Mia Hashibe, and Cornelia M. Ulrich

cancer, bladder cancer, and cancers of the respiratory system, whereas those with breast cancer, cutaneous melanoma, and prostate cancer had the lowest prevalence. Findings of previous studies have pointed in the same direction. 21 , 27 , 31 , 32 In

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Kerry Schaffer, Narmadha Panneerselvam, Kah Poh Loh, Rachel Herrmann, Ian R. Kleckner, Richard Francis Dunne, Po-Ju Lin, Charles E. Heckler, Nicholas Gerbino, Lauren B. Bruckner, Eugene Storozynsky, Bonnie Ky, Andrea Baran, Supriya Gupta Mohile, Karen Michelle Mustian, and Chunkit Fung

. Exercise programming and counseling preferences in bladder cancer survivors: a population-based study . J Cancer Surviv 2007 ; 1 : 27 – 34 . 57. Cobiac LJ Vos T Barendregt JJ . Cost-effectiveness of interventions to promote physical activity

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Josh Lauring, Ben Ho Park, and Antonio C. Wolff

activating PIK3CA mutations, 54 , 55 whereas other studies have found no correlation between mutation and response, although most of these studies are underpowered. 56 Recently, mutation of the TSC1 and TSC2 genes in bladder cancers was found to correlate

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Al B. Benson III, Thomas A. Abrams, Edgar Ben-Josef, P. Mark Bloomston, Jean F. Botha, Bryan M. Clary, Anne Covey, Steven A. Curley, Michael I. D'Angelica, Rene Davila, William D. Ensminger, John F. Gibbs, Daniel Laheru, Mokenge P. Malafa, Jorge Marrero, Steven G. Meranze, Sean J. Mulvihill, James O. Park, James A. Posey, Jasgit Sachdev, Riad Salem, Elin R. Sigurdson, Constantinos Sofocleous, Jean-Nicolas Vauthey, Alan P. Venook, Laura Williams Goff, Yun Yen, and Andrew X. Zhu

-naive, unresectable gall bladder cancer . Br J Cancer 2004 ; 90 : 1516 – 1520 . 210 Thongprasert S Napapan S Charoentum C Moonprakan S . Phase II study of gemcitabine and cisplatin as first-line chemotherapy in inoperable biliary tract carcinoma . Ann

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Dawn Provenzale, Samir Gupta, Dennis J. Ahnen, Travis Bray, Jamie A. Cannon, Gregory Cooper, Donald S. David, Dayna S. Early, Deborah Erwin, James M. Ford, Francis M. Giardiello, William Grady, Amy L. Halverson, Stanley R. Hamilton, Heather Hampel, Mohammad K. Ismail, Jason B. Klapman, David W. Larson, Audrey J. Lazenby, Patrick M. Lynch, Robert J. Mayer, Reid M. Ness, Scott E. Regenbogen, Niloy Jewel Samadder, Moshe Shike, Gideon Steinbach, David Weinberg, Mary Dwyer, and Susan Darlow

. Patients with Lynch syndrome mismatch repair gene mutations are at higher risk for not only upper tract urothelial cancer but also bladder cancer . Eur Urol 2013 ; 63 : 379 – 385 . 77. Win AK Lindor NM Jenkins MA . Risk of breast cancer in