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-related autoimmune retinopathy and was referred to an oncologist for further evaluation. She had no detectable antiretinal antibodies. She was a nonsmoker with no significant past medical history. She denied weight loss, fever, abdominal pain, dysuria, vaginal

and 20/150 in the left eye. BRAF/MEK inhibition was discontinued immediately given concern for serous retinopathy/uveitis, and the patient was started on topical corticosteroid drops with no improvement and even progression of symptoms. On repeat

cerebellar degeneration . Nat Med 1998 ; 4 : 1321 – 1324 . 40. Polans AS Witkowska D Haley TL . Recoverin, a photoreceptor-specific calcium-binding protein, is expressed by the tumor of a patient with cancer-associated retinopathy . Proc Natl

retinopathy were frequently reported in this population. Clinicians should be informed about how to prevent and treat these conditions, which may include dose modifications, over-the-counter and prescription medications, lifestyle adjustments, and, when

. Additionally, some medications are associated with rare but serious ocular complications, such as retinal vein occlusion 56 and retinopathy, whereas radiation treatment for proptosis may result in cataracts and retinopathy. 57 The National Registry of Drug

. The kinase inhibitor PKC412 suppresses epiretinal membrane formation and retinal detachment in mice with proliferative retinopathies . Invest Ophthalmol Vis Sci 2003 ; 44 : 3656 – 3662 . 92 Sotlar K Marafioti T Griesser H . Detection of

, and secondary enucleation were similar across treatments. 86 Risk of cataract appeared similar across treatments, but SRS appeared to be associated with higher rates of certain complications, including neovascular glaucoma, radiation retinopathy, and

tolerated in 30 patients, with dose-limiting toxicities in 5 patients (cetuximab infusion reaction, n=2; grade 2 retinopathy, n=2; grade 2 decreased ejection fraction, n=1). Of the 30 patients, 19 (63%) experienced a grade 3 or 4 AE, including fatigue (grade

due to the high incidence of serous retinopathy with MEK inhibitors. 31 , 32 Histopathologic Characterization of LCH LCH tumors often demonstrate neoplastic histiocytes admixed with marked inflammatory cell infiltration. On hematoxylin and eosin

Table 10 , reports from multiple clinical trials have highlighted a few other rare high-grade AEs of special interest, including an assortment of ocular AEs (eg, retinopathies, blurred vision, retinal detachment, uveitis), QT prolongation, decreased