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Developmental Therapeutics for Myelodysplastic Syndromes

Aung Naing, Lubomir Sokol, and Alan F. List

The management strategy for patients with myelodysplastic syndromes (MDS) has evolved from sole reliance on supportive measures to active treatment guided by disease risks. Recent progress in understanding the molecular pathogenesis of MDS has accelerated the discovery of new therapeutic targets, and consequently launched the development of several novel therapeutics that are currently in varied stages of clinical testing. One such agent is lenalidomide, which has shown remarkable effectiveness in the cytogenetically defined subset of MDS with the chromosome 5q31 deletion. The advent of new and effective targeted therapeutics may beneficially affect outcomes of an ever-increasing number of patients with MDS. This discussion summarizes the preliminary results of selected novel therapeutics.

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Specific Targets in Sarcoma and Developmental Therapeutics

David M. Thomas and Andrew J. Wagner

frequent coamplification of MDM2 and CDK4 in WDLPS/DDLPS is of particular interest because it presents an opportunity for combined use of targeted therapeutics. 31 Vascular Endothelial Growth Factor Receptor Pathway Vascular endothelial

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A Review of VEGF/VEGFR-Targeted Therapeutics for Recurrent Glioblastoma

David A. Reardon, Scott Turner, Katherine B. Peters, Annick Desjardins, Sridharan Gururangan, John H. Sampson, Roger E. McLendon, James E. Herndon II, Lee W. Jones, John P. Kirkpatrick, Allan H. Friedman, James J. Vredenburgh, Darell D. Bigner, and Henry S. Friedman

tempered by relatively modest improvements in overall survival, difficulties in assessing response after anti-VEGF therapeutics, and an inability to identify effective therapy after bevacizumab failure. Nonetheless, initial results have sparked a flurry of

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Management of Recurrent Small Cell Lung Cancer

Bryan J. Schneider

Small cell lung cancer remains one of the more frustrating malignancies for oncologists to treat. Although responses to initial platinum-based chemotherapy are high, most are not durable, and many patients are candidates for further palliative chemotherapy. Therapeutic options include reinduction or single-agent chemotherapy, depending on the duration of response to front-line treatment. Topotecan is the only approved agent for patients with relapsed disease. Several phase II studies have shown a modest benefit with other agents used today, although combination chemotherapy should be avoided because of increased toxicity. Palliative care should always be the focus, especially in patients with recurrent or chemorefractory small cell lung cancer and a poor performance status.

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New Meets Old: A Case Study and Review of Novel Therapeutics for the Treatment of CLL in Older Patients

Neel K. Gupta and Charalambos Andreadis

evaluated in larger frontline studies, and thus its utility remains unclear. 15 Striking a balance between efficacy and toxicity in this patient population is therefore challenging; however, the development of novel therapeutics and targeted agents has

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Introduction: Addressing Challenges in Multiple Myeloma Management in an Era of New Therapeutics

Sundar Jagannath

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Volume 8 (2010): Issue Suppl_1 (Feb 2010): Addressing Challenges in Multiple Myeloma Management in an Era of New Therapeutics

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Targeted Therapy for Metastatic Non–Small Cell Lung Cancer

Presented by: Gregory J. Riely

Annual Conference, Dr. Riely, who is also a member of the NCCN Guidelines Panel for NSCLC, described which oncogenic molecular alterations can be targeted, and the efficacy and safety of their corresponding therapeutics according to line of treatment

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Exceptional Response to Erdafitinib in FGFR2-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

Camille F. Ng, John Glaspy, Veronica R. Placencio-Hickok, Shant Thomassian, Jun Gong, Arsen Osipov, Andrew E. Hendifar, and Natalie Moshayedi

Despite advances in cancer therapeutics, pancreatic ductal adenocarcinoma (PDAC) remains among the deadliest malignancies, with a poor prognosis at time of diagnosis, reflecting a 5-year survival rate of approximately 10% across all stages and 2

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Nanotechnologies in Cancer Treatment and Diagnosis

Stephanie A. Morris, Dorothy Farrell, and Piotr Grodzinski

field of nanotechnology has emerged as an approach with the potential to produce novel diagnostics and therapeutics. At the nanoscale, materials are comparable in size to biological entities. They exhibit the ability to traverse the cellular environment