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Current Concepts in the Evaluation and Treatment of Patients With Diffuse Malignant Peritoneal Mesothelioma

Keli Turner, Sheelu Varghese, and H. Richard Alexander

Cytoreduction and Regional Chemotherapy DMPM typically remains localized to the abdominal cavity, with spread to the pleura (via direct extension or transdiaphragmatic lymphatics) occurring rarely and only at advanced stages of disease. 11 , 15 , 17 Based on

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Do All Patients With Polycythemia Vera or Essential Thrombocythemia Need Cytoreduction?

Kamya Sankar and Brady L. Stein

). 9 Although hematologists hope to modify disease biology and prevent transformation to MF/AML, 9 this is not expected with current therapies. Cytoreduction is typically prescribed for patients with ET or PV who have a high risk for vascular

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Surgery for Ovarian Cancer: Rationale and Guidelines

Benjamin E. Greer, Ron E. Swensen, and Heidi J. Gray

cytoreductive surgery for ovarian carcinoma . Gynecol Oncol 1995 ; 58 : 244 – 247 . 24 Gillette-Cloven N Burger RA Monk BJ . Bowel resection at the time of primary cytoreduction for epithelial ovarian cancer . J Am Coll Surg 2001 ; 193 : 626

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Interferons as the First Choice of Cytoreduction in Essential Thrombocythemia and Polycythemia Vera

Joan How and Gabriela Hobbs

considered as well when evaluating a patient’s overall risk for thrombosis. 9 In addition to aspirin and the maintenance of a hematocrit (Hct) <45% in PV, 10 cytoreduction with hydroxyurea has resulted in improved thrombosis-free survival in high

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CLO20-069: Evaluation and analysis of postoperative complications after primary cytoreduction for 47 cases of advanced epithelial ovarian cancer at stage IIIc and IV RUNNING HEAD (maximum 40 characters): Complications after primary cytoreduction in ovarian cancer

Ying Zhou, Chenchen Zhu, Zhen Shen, Yanhu Xie, Wei Zhang, Jing Zhu, Tianjiao Zhang, Min Li, Jiwei Qin, Shuai Yin, Rongzhu Chen, Wei Wei, Sinan Sun, Guihong Wang, Zheng Zhou, Hanhui Yao, Dabao Wu, and Björn Nashan

Objective: To evaluate the postoperative complications and their impacts on the patients who have performed with primary cytoreduction (including extra upper abdominal surgery, EUAS) of advanced epithelial ovarian cancer at stage IIIc and IV

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Controversies in the Surgical Management of Renal Cancer

Michael P. Porter and Paul H. Lange

Renal tumors are a common cause of cancer, and renal cell carcinoma accounts for the vast majority of the renal tumors in the United States. The past two decades have produced numerous advances in the treatment of localized and metastatic renal cell carcinoma. Nephron-sparing surgery, laparoscopic nephrectomy, and energy-ablative techniques are now in the armamentarium of the urologist. The role of adrenalectomy and lymphadenectomy are better understood today than in decades past, and recent advances in the understanding of immunotherapy, cytoreductive nephrectomy, and metastatic disease have also improved treatment for this disease. As is often the case as technology and knowledge evolve, controversies regarding the surgical treatment of renal cancer exist. This article outlines some of these controversies and reviews the evidence surrounding each.

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The Role of Cytoreductive/Debulking Surgery in Ovarian Cancer

Mark T. Wakabayashi, Paul S. Lin, and Amy A. Hakim

Edited by Kerrin G. Robinson

Clin Oncol 2005 ; 23 : 8802 – 8811 . 13. Berchuck A Iversen ES Lancaster JM . Prediction of optimal versus suboptimal cytoreduction of advanced-stage serous ovarian cancer with the use of microarrays . Am J Obstet Gynecol 2004 ; 190

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Principles of Surgical Management of Peritoneal Mesothelioma

Jessica A. Steadman and Travis E. Grotz

complete removal of all visible disease, referred to as complete cytoreduction. 3 – 7 In well-selected patients, 5-year overall survival (OS) approaches 68%. 8 To achieve these optimal results, appropriate patient selection and expert surgical management

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Ovarian Cancer Guidelines: Treatment Progress and Controversies

Robert J. Morgan Jr.

resulted in significant changes in recommendations. For example, data suggesting a correlation between patient survival and extent of initial surgical debulking resulted in strengthening recommendations. “Optimal” cytoreduction is defined as less than 1

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The Role of Maintenance Therapy in the Treatment of Multiple Myeloma

Ashraf Z. Badros

at least a VGPR, supporting the hypothesis that post-transplantation thalidomide provides additional cytoreduction rather than eradication or suppression of minimal residual disease. Currently, however, initial response to therapy should not be used