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Highlights of the NCCN Oncology Research Program

by the ORP. This feature highlights an NCCN study funded through the grant mechanism. Phase I Trial of Combination Afatinib and Necitumumab in EGFR Mutation–Positive Non–Small Cell Lung Cancer With Acquired Resistance to First- or Third

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Moving Forward With Expanding to an “All-RAS Mutational Analysis” in Metastatic Colorectal Cancer: Beyond KRAS Mutations

Tanios Bekaii-Saab

The advent of biologic agents such as those that target the epidermal growth factor receptor (EGFR) has favorably impacted outcomes for patients with metastatic colorectal cancer (mCRC). An important downstream component of EGFR is the RAS

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Oncology Research Program

Sensitizing EGFR Mutation or Have Never Smoked Principal Investigator: Joseph Treat, MD Condition: Stage IV nonsquamous non–small cell lung cancer Institution: Fox Chase Cancer Center Patients with non–small cell lung cancer (NSCLC) who harbor an EGFR

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Highlights of the NCCN Oncology Research Program

by the ORP. This feature highlights an NCCN study funded through the grant mechanism. A Phase II Study of Osimertinib in Combination With Selumetinib in EGFR Inhibitor–Naïve Advanced EGFR -Mutant Lung Cancer Principal Investigator: Pasi Janne, MD

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Highlights of the NCCN Oncology Research Program

by the ORP. This feature highlights an NCCN study funded through the grant mechanism. A Phase II Study of Osimertinib in Combination With Selumetinib in EGFR Inhibitor–Naïve Advanced EGFR -Mutant Lung Cancer Principal Investigator: Pasi Janne, MD

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CLO23-046: Pooled Outcomes of Anti-BRAF Agents in Advanced Stage Colorectal Cancer

Mackenzie Taychert, Ankita Aggarwal, David Tabagari, Urja Nagadia, Sai Gajagowni, Venkata Vosuri, and Kushal Naha

are suboptimal. Targeted treatment with anti-BRAF agents plus anti-EGFR antibodies/chemotherapy have shown promising results based on a smaller number of studies. Here we report a pooled estimate of clinical activity of anti-BRAF agents plus anti-EGFR

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Highlights of the NCCN Oncology Research Program

overseen by the ORP. This feature highlights an NCCN study funded through the grant mechanism. A Phase II Study of Osimertinib in Combination With Selumetinib in EGFR Inhibitor-Naïve Advanced EGFR -Mutant Lung Cancer Principal Investigator: Pasi

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HSR23-092: Real-World Analysis Examining Cost of Early Disease Progression Among Patients With Epidermal Growth Factor Receptor Mutated Metastatic Non–Small Cell Lung Cancer

Nicole Princic, Elizabeth Marrett, Winghan Jacqueline Kwong, Donna McMorrow, Hana Schwartz, and Janakiraman Subramanian

Background: In the US, approximately 25% of patients with NSCLC have an EGFR exon 19 deletion or L858R mutation ( EGFR m) for which tyrosine kinase inhibitors (TKI) have been shown to extend progression-free survival. Data examining the

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HSR24-161: Biomarker Testing, Surgical Outcomes, and Adjuvant Therapy Rates Among Patients With Resected Non–Small Cell Lung Cancer (NSCLC) in the Community Setting in the United States (US), 2019–2023

Xiaohan Hu, Yu-Han Kao, Ashwini Arunachalam, Diana Chirovsky, Yiru Wang, Chenan Zhang, Kaitlyn Kane, and Ayman Samkari

Background: The management of resectable early-stage NSCLC in the US has been rapidly evolving since late 2020 when the EGFR tyrosine kinase inhibitor (TKI) osimertinib was approved as adjuvant therapy for resected EGFR-mutated NSCLC. After

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Oncology Research Program

scientific peer-review process and are overseen by the ORP. An NCCN study funded through the grant mechanism is highlighted below. A Phase II Study of Osimertinib in Combination With Selumetinib in EGFR Inhibitor–Naïve Advanced EGFR -Mutant Lung