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Integration of Systemic and Liver-Directed Therapies for Locally Advanced Hepatocellular Cancer: Harnessing Potential Synergy for New Therapeutic Horizons

Eric H. Bent, Eric Wehrenberg-Klee, Eugene J. Koay, Lipika Goyal, and Jennifer Y. Wo

advanced, multifocal, or unresectable HCC disease (BCLC stage B), locoregional therapies (LRTs) including trans-arterial chemoembolization (TACE), trans-arterial radioembolization (TARE), and external-beam radiation therapy (EBRT) are commonly considered

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First-Line Treatment of Widely Metastatic BRAF-Mutated Salivary Duct Carcinoma With Combined BRAF and MEK Inhibition

Victor T.G. Lin, Lisle M. Nabell, Sharon A. Spencer, William R. Carroll, Shuko Harada, and Eddy S. Yang

resection, extracapsular extension, and tumor involvement of 31 of 40 resected lymph nodes. He was enrolled in a clinical trial comparing adjuvant chemoradiation versus radiation therapy (RT) alone (RTOG 1008), and was randomly assigned to treatment with RT

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NCCN Guidelines Insights: Small Cell Lung Cancer, Version 2.2018

Gregory P. Kalemkerian, Billy W. Loo Jr, Wallace Akerley, Albert Attia, Michael Bassetti, Yanis Boumber, Roy Decker, M. Chris Dobelbower, Afshin Dowlati, Robert J. Downey, Charles Florsheim, Apar Kishor P. Ganti, John C. Grecula, Matthew A. Gubens, Christine L. Hann, James A. Hayman, Rebecca Suk Heist, Marianna Koczywas, Robert E. Merritt, Nisha Mohindra, Julian Molina, Cesar A. Moran, Daniel Morgensztern, Saraswati Pokharel, David C. Portnoy, Deborah Rhodes, Chad Rusthoven, Jacob Sands, Rafael Santana-Davila, Charles C. Williams Jr, Karin G. Hoffmann, and Miranda Hughes

fraction, and early development of widespread metastases. These NCCN Guidelines Insights focus on recent updates in immunotherapy, systemic therapy, and radiation therapy (RT) for patients with SCLC. For a full list of the 2018 updates, see the complete

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Partial-Breast Radiation for Early Staged Breast Cancers: Hypothesis, Existing Data, and a Planned Phase III Trial

Beryl McCormick

breast by radiation therapy . Cancer 1977 ; 39 : 2840 – 2845 . 2 Prosnitz L Goldenberg I Packard A . Radiation therapy as initial treatment for early stage cancer of the breast without mastectomy . Cancer 1977 ; 39 : 917 – 923 . 3

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Targeting PD-L1 After Adjuvant Radiation in Subtotally Resected Primary Pineal Melanoma: A Case Report and Literature Review

Justin Famoso, Gerald Lemole, Srinath Sundararajan, and Baldassarre Stea

administered with a 5-field intensity-modulated radiation therapy technique. Image guidance was achieved with daily kilovoltage x-ray imaging using the ExacTrac system by Brainlab. On completion of RT, the patient was evaluated for systemic therapy options

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Clinical Discussion and Review of the Management of Brain Metastases

Priscilla K. Brastianos, William T. Curry, and Kevin S. Oh

RPA, but more objective and user friendly. Since then, diagnosis-specific GPAs have been developed, 6 including the Breast-GPA, which also accounts for genetic subtype in addition to KPS and age. 7 Radiation Therapy Whole-Brain Radiation

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Locally Recurrent Endometrial Cancer: A Case Report

Srinivas K. Tantravahi, and Theresa L. Werner

recurrence of endometrial cancer is prior radiation therapy at the site of recurrence. In the case of this patient with locally recurrent endometrial cancer and no prior radiation therapy, NCCN recommendations include tumor-directed radiation therapy, and

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Soft Tissue Sarcoma, Version 2.2014

Margaret von Mehren, R. Lor Randall, Robert S. Benjamin, Sarah Boles, Marilyn M. Bui, Ephraim S. Casper, Ernest U. Conrad III, Thomas F. DeLaney, Kristen N. Ganjoo, Suzanne George, Ricardo J. Gonzalez, Martin J. Heslin, John M. Kane III, Joel Mayerson, Sean V. McGarry, Christian Meyer, Richard J. O’Donnell, Alberto S. Pappo, I. Benjamin Paz, John D. Pfeifer, Richard F. Riedel, Scott Schuetze, Karen D. Schupak, Herbert S. Schwartz, Brian A. Van Tine, Jeffrey D. Wayne, Mary Anne Bergman, and Hema Sundar

cancer syndromes caused by germline mutations in several different genes have been associated with inherited predisposition for the development of STS. 2 - 7 Radiation therapy (RT) and/or chemotherapy are often used as an adjunct to surgery for patients

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Supportive Care in Head and Neck Cancers: Multidisciplinary Management

Presented by: Jimmy J. Caudell, David G. Pfister, and Randal S. Weber

Although a broad spectrum of quality-of-life issues impact patients with head and neck cancers (HNC), a few are paramount: receiving inadequate nutrition and having dental complications after radiation therapy. In a panel moderated by David G

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Gastric MALT Lymphoma Treated With Primary Radiotherapy in the Setting of Autoimmune Disease

Chelsea C. Pinnix, Valerie Reed, and Bouthaina Dabaja

, SS, and secondary hypothyroidism. She had no history of radiation therapy or of lupus or scleroderma. She denied history of renal disease. She did report xerostomia and eye dryness requiring her to constantly carry a water bottle and use lubricating