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Cancer Principal Investigator: Mario Pineda, MD, PhD Condition: Recurrent epithelial ovarian cancer, recurrent fallopian tube cancer, and recurrent primary peritoneal cancer Institution: Robert H. Lurie Comprehensive Cancer Center of Northwestern

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New Treatment Options Lead to Steady Progress Against Ovarian Cancer Although finding effective screening tools remains a priority, new treatment options for women with ovarian cancer, such as those outlined in the updated NCCN Clinical Practice

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Cancer Principal Investigator: Mario Pineda, MD, PhD Condition: Recurrent epithelial ovarian cancer, recurrent fallopian tube cancer, and recurrent primary peritoneal cancer Institution: Robert H. Lurie Comprehensive Cancer Center of Northwestern

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Tarra Evans and Ursula Matulonis

malignancies. NGS and Molecular Analysis of Gynecologic Cancers Ovarian Cancer One of the most important and influential uses of NGS occurred with The Cancer Genome Atlas (TCGA) project, a multinational collaboration to systematically characterize the

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options for patients with cancer. For more information about the NCCN ORP, visit NCCN.org/ORP . NCCN Publishes Updated Patient Resource for Ovarian Cancer With Support From the National Ovarian Cancer Coalition NCCN has published an updated and

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Mary B. Daly, Jennifer E. Axilbund, Saundra Buys, Beth Crawford, Carolyn D. Farrell, Susan Friedman, Judy E. Garber, Salil Goorha, Stephen B. Gruber, Heather Hampel, Virginia Kaklamani, Wendy Kohlmann, Allison Kurian, Jennifer Litton, P. Kelly Marcom, Robert Nussbaum, Kenneth Offit, Tuya Pal, Boris Pasche, Robert Pilarski, Gwen Reiser, Kristen Mahoney Shannon, Jeffrey R. Smith, Elizabeth Swisher, and Jeffrey N. Weitzel

hereditary cancers, advances in molecular genetics have identified several genes associated with inherited susceptibility to breast and/or ovarian cancers (e.g., BRCA1, BRCA2, PTEN, TP53, CDH1 ) and provided a means of characterizing the specific gene

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Sofia D. Merajver and Kara Milliron

history of ovarian cancer . Breast Cancer Res Treat 1993 ; 28 : 115 – 120 . 9 Claus EB Risch N Thompson WD . Autosomal dominant inheritance of early onset breast cancer . Cancer 1994 ; 73 : 643 – 651 . 10 Claus EB Schildkraut

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scientific peer-review process and are overseen by the ORP. NCCN studies funded through the grant mechanism are highlighted below. Platinum-Sensitive Ovarian Cancer: The Use of Tivozanib as Maintenance Therapy Post Chemotherapy in Patients With

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Guidelines, the NCCN Compendium, and the NCCN Chemotherapy Order Templates (NCCN Templates), please visit NCCN.org . Updated NCCN Guidelines for Patients: Ovarian Now Available The NCCN Guidelines for Patients: Ovarian Cancer, Version 1.2013, is now

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Kenneth Offit

cancer is around 16%, and common cancer susceptibilities include, for example, Lynch syndrome, BRCA1 / 2 , hereditary breast and ovarian cancer syndrome, and lobular breast cancer with CDH1 mutations (associated with hereditary diffuse gastric cancer