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Jarushka Naidoo

Another study showed that the microbiome is predictive not only of response but also of toxicity: the investigators demonstrated that the presence of a certain species of microbe may be protective against the development of colitis from anti–CTLA-4 therapy

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Presenter: Robert I. Haddad

-1 and CTLA-4 pathways, comparing combination nivolumab + ipilimumab to the EXTREME regimen as first-line treatment in patients with recurrent/metastatic HNSCC ( identifier: NCT02741570). Patients with PD-L1–positive tumors appear

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Presenter: Arlene O. Siefker-Radtke

immune-related toxicities after treatment with the CTLA-4 antibody ipilimumab in combination with gemcitabine + cisplatin. 5 This chemoimmunotherapy regimen did not appear to impact OS. Furthermore, another study suggested that chemotherapy may promote

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Fangwen Zou, Hamzah Abu-Sbeih, Weijie Ma, Yuanzun Peng, Wei Qiao, Jianbo Wang, Amishi Y. Shah, Isabella C. Glitza Oliva, Sarina A. Piha-Paul, John A. Thompson, Hao Chi Zhang, Anusha S. Thomas, and Yinghong Wang

-mediated diarrhea and colitis (IMDC), the second most common irAE, limits the use of ICIs. 5 The incidence and severity of IMDC vary depending on the ICI regimen. Severe forms are attributed to anti–CTLA-4–based regimens, 6 and clinical symptoms range from self

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Reece J. Knippel and Cynthia L. Sears

. The gut microbiome is proposed as important to the success of immunotherapy, with most data limited to immune checkpoint inhibitors targeting the PD-1 axis and/or the CTLA-4 axis in melanoma. 3 However, across studies, consistent gut microbiome

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Dawn Goetz

(CTLA)-4 targeted therapy. Tremelimumab and ipilimumab are humanized anti–CTLA-4 antibodies currently under investigation in many solid tumors, including prostate cancer. 16 Immune-based therapies pose many challenges, particularly in designing

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Kelly N. Fitzgerald and Chung-Han Lee

inhibitors pembrolizumab and nivolumab and the CTLA-4 inhibitor ipilimumab. In the first-line setting, the combination of ipilimumab and nivolumab (ipi/nivo) is the only preferred treatment option for ccRCC using immunotherapy alone in the NCCN Guidelines

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Michelle C. Nguyen, Manisha H. Shah, David A. Liebner, Floor J. Backes, John Phay, and Lawrence A. Shirley

hypothesis has also been supported by Herbst et al, 14 who demonstrated associations in tumor expression of PD-L1, T-helper type 1 gene, and CTLA4 , and absence of fractalkine ( CX3CL1 ) in baseline tumors with response rates. The tumor microenvironment

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Rahel Demisse, Neha Damle, Edward Kim, Jun Gong, Marwan Fakih, Cathy Eng, Leslie Oesterich, Madison McKenny, Jingran Ji, James Liu, Ryan Louie, Kit Tam, Sepideh Gholami, Wissam Halabi, Arta Monjazeb, Farshid Dayyani, and May Cho

with chemotherapy led to significant response. We showed that neoadjuvant therapy using a single-agent PD-1 inhibitor, combined PD-1/CTLA-4 inhibitors, or PD-1 inhibitor plus FOLFOX combination can be a safe and effective treatment option in selected

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Presenter: Genevieve Boland

, hazard ratio; Ipi, ipilimumab; Nivo, nivolumab; NR, not reached; Pembro, pembrolizumab; RFS, relapse-free survival. In 2014, the CTLA-4 inhibitor ipilimumab became the first approved immunotherapy for the adjuvant treatment of melanoma, but its