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David Scott Miller, Gini Fleming, and Marcus E. Randall
Charles L. Loprinzi and Peter M. Ravdin
. Early Breast Cancer Trialists' Collaborative Group . Lancet 1998 ; 352 : 930 – 942 . 16 Anonymous : Tamoxifen for early breast cancer: An overview of randomized trials. Early Breast Cancer Trialists' Collaborative Group . Lancet 1998
Sofia D. Merajver and Kara Milliron
. 13 Fisher B Costantino JP Wickerham DL . Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study . J Natl Cancer Inst 1998 ; 90 : 1371 – 1388 . 14 Rockhill B Spiegelman
Susan M. Domchek, Jill E. Stopfer, and Timothy R. Rebbeck
: 1358 – 1365 . 45. Narod SA Brunet JS Ghadirian P . Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Hereditary Breast Cancer Clinical Study Group . Lancet 2000 ; 356 : 1876
Melinda L. Telli, William J. Gradishar, and John H. Ward
tumors >0.5 cm, the NCCN Guidelines state as a category 1 recommendation that clinicians should “strongly consider the 21-gene assay.” The assay predicts the benefit of chemotherapy when added to tamoxifen as adjuvant therapy, regardless of menopausal
Sara H. Javid, L. Christine Fang, Larissa Korde, and Benjamin O. Anderson
breast-conserving surgery followed by radiation therapy, or mastectomy. 11 - 14 Tamoxifen is also considered as possible adjuvant therapy for patients with estrogen receptor-positive DCIS, both for reduction of local recurrence risk after breast
William J. Gradishar, Benjamin O. Anderson, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H. Allison, Sarah L. Blair, Harold J. Burstein, Chau Dang, Anthony D. Elias, Sharon H. Giordano, Matthew P. Goetz, Lori J. Goldstein, Steven J. Isakoff, Jairam Krishnamurthy, Janice Lyons, P. Kelly Marcom, Jennifer Matro, Ingrid A. Mayer, Meena S. Moran, Joanne Mortimer, Ruth M. O'Regan, Sameer A. Patel, Lori J. Pierce, Hope S. Rugo, Amy Sitapati, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, Erica M. Stringer-Reasor, Melinda L. Telli, John H. Ward, Jessica S. Young, Jennifer L. Burns, and Rashmi Kumar
-negative, advanced breast cancer were randomly assigned to first-line treatment with ribociclib or placebo with goserelin plus either a nonsteroidal AI or tamoxifen. 31 An improvement in PFS was seen with the addition of ribociclib (median PFS, 24 vs 13
receptor's ligand by blocking estrogen production via aromatase enzymatic inhibition. Tamoxifen is a nonsteroidal triphenylethylene derivative that acts as a SERM, with antagonist properties in mammary tissue. Tamoxifen has demonstrated efficacy and a
Sharon H. Giordano, Anthony D. Elias, and William J. Gradishar
the global MONALEESA-7 trial of almost 700 premenopausal or perimenopausal women rendered postmenopausal. 17 Patients had received no prior endocrine therapy for metastatic disease; by physician's choice they received an AI (mostly) or tamoxifen, plus
Rachel F. Dear, Kevin McGeechan, Megan B. Barnet, Alexandra L. Barratt, and Martin H.N. Tattersall
-consistent/NCCN-nonconsistent trials involved adjuvant endocrine therapy; 2 used a gonadotropin-releasing hormone (GnRH) agonist and tamoxifen in premenopausal women, and 4 used tamoxifen in postmenopausal women. A GnRH agonist with tamoxifen is included in the AGO guidelines for
