with MPNs experience a unique constellation of physical symptoms, such as pruritus, night sweats, bone and splenic pain, fatigue, and fevers. Symptom burden can be similar in severity to the experience of patients with metastatic cancer or acute myeloid
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Daniel C. McFarland, Kelly M. Shaffer, Heather Polizzi, John Mascarenhas, Marina Kremyanskaya, Jimmie Holland, and Ronald Hoffman
Smith Giri, Shadi Hamdeh, Vijaya Raj Bhatt, and James K. Schwarz
experienced disease control for 7 months with the combination of chemotherapy and sorafenib. Case Presentation A 65-year-old man presented to the emergency room who had experienced worsening pain in both calves during the past 2 to 3 weeks, fever and
Maria R. Baer and Ivana Gojo
cytogenetic risk group. Thus, clofarabine shows encouraging results in older patients, including those with unfavorable karyotypes. However, the treatment is myelosuppressive, with most patients requiring hospitalization for neutropenic fever or infection
Karisa C. Schreck, Andrew Guajardo, Doris D.M. Lin, Charles G. Eberhart, and Stuart A. Grossman
dabrafenib at 150 mg twice daily and trametinib at 2 mg daily, with a Karnofsky performance status (KPS) of 50 and an ECOG performance status (PS) of 3. Treatment was complicated by fevers and a rash that responded to steroids. The steroids were titrated to
Lindsey Robert Baden, Sankar Swaminathan, Michael Angarone, Gayle Blouin, Bernard C. Camins, Corey Casper, Brenda Cooper, Erik R. Dubberke, Ashley Morris Engemann, Alison G. Freifeld, John N. Greene, James I. Ito, Daniel R. Kaul, Mark E. Lustberg, Jose G. Montoya, Ken Rolston, Gowri Satyanarayana, Brahm Segal, Susan K. Seo, Shmuel Shoham, Randy Taplitz, Jeffrey Topal, John W. Wilson, Karin G. Hoffmann, and Courtney Smith
development of symptoms that are suggestive of influenza (eg, high fever, coryza, myalgia, dry cough), especially during community outbreaks. Both the Infectious Diseases Society of America (2007) and CDC guidelines (2011) recommend antiviral treatment with
Irene Dy, Rangaswamy Chintapatla, Isabel Preeshagul, and Daniel Becker
-related autoimmune retinopathy and was referred to an oncologist for further evaluation. She had no detectable antiretinal antibodies. She was a nonsmoker with no significant past medical history. She denied weight loss, fever, abdominal pain, dysuria, vaginal
Radhika Gangaraju, Soo J. Kim, Jing-Fei Dong, Sabina Swierczek, and Josef T. Prchal
, renal dysfunction, and fever. 1 Only a minority of patients present with all of these symptoms, which overlap with other clinical conditions, posing a diagnostic challenge. 2 Acquired TTP occurs due to development of inhibitory antibodies against von
Mitul Gandhi and Adam Petrich
persistent fevers. A PET scan performed as part of his pretransplant evaluation was remarkable for a hypermetabolic left supraclavicular node, and a bone marrow biopsy confirmed recurrence of cHL. The neoplastic cells were positive for CD15, CD30, and Epstein
Patrick A. Brown and Bijal Shah
toxicity,” said Dr. Shah. “I think we have to be cognizant of the fact that these therapies will make people sick in the short term.” As for CRS, more common symptoms include fever and hypotension. However, some patients may experience more severe
Aby Z. Philip
previously healthy 68-year-old woman presented with fatigue, night sweats, abdominal fullness, loss of appetite, and low-grade fevers. CT scan of her chest, abdomen, and pelvis revealed diffuse lymphadenopathy involving supraclavicular, axillary, mediastinal
