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Karisa C. Schreck, Andrew Guajardo, Doris D.M. Lin, Charles G. Eberhart, and Stuart A. Grossman

dabrafenib at 150 mg twice daily and trametinib at 2 mg daily, with a Karnofsky performance status (KPS) of 50 and an ECOG performance status (PS) of 3. Treatment was complicated by fevers and a rash that responded to steroids. The steroids were titrated to

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Maria R. Baer and Ivana Gojo

cytogenetic risk group. Thus, clofarabine shows encouraging results in older patients, including those with unfavorable karyotypes. However, the treatment is myelosuppressive, with most patients requiring hospitalization for neutropenic fever or infection

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Daniel C. McFarland, Kelly M. Shaffer, Heather Polizzi, John Mascarenhas, Marina Kremyanskaya, Jimmie Holland, and Ronald Hoffman

with MPNs experience a unique constellation of physical symptoms, such as pruritus, night sweats, bone and splenic pain, fatigue, and fevers. Symptom burden can be similar in severity to the experience of patients with metastatic cancer or acute myeloid

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Lindsey Robert Baden, Sankar Swaminathan, Michael Angarone, Gayle Blouin, Bernard C. Camins, Corey Casper, Brenda Cooper, Erik R. Dubberke, Ashley Morris Engemann, Alison G. Freifeld, John N. Greene, James I. Ito, Daniel R. Kaul, Mark E. Lustberg, Jose G. Montoya, Ken Rolston, Gowri Satyanarayana, Brahm Segal, Susan K. Seo, Shmuel Shoham, Randy Taplitz, Jeffrey Topal, John W. Wilson, Karin G. Hoffmann, and Courtney Smith

development of symptoms that are suggestive of influenza (eg, high fever, coryza, myalgia, dry cough), especially during community outbreaks. Both the Infectious Diseases Society of America (2007) and CDC guidelines (2011) recommend antiviral treatment with

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Mitul Gandhi and Adam Petrich

persistent fevers. A PET scan performed as part of his pretransplant evaluation was remarkable for a hypermetabolic left supraclavicular node, and a bone marrow biopsy confirmed recurrence of cHL. The neoplastic cells were positive for CD15, CD30, and Epstein

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Irene Dy, Rangaswamy Chintapatla, Isabel Preeshagul, and Daniel Becker

-related autoimmune retinopathy and was referred to an oncologist for further evaluation. She had no detectable antiretinal antibodies. She was a nonsmoker with no significant past medical history. She denied weight loss, fever, abdominal pain, dysuria, vaginal

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Patrick A. Brown and Bijal Shah

toxicity,” said Dr. Shah. “I think we have to be cognizant of the fact that these therapies will make people sick in the short term.” As for CRS, more common symptoms include fever and hypotension. However, some patients may experience more severe

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Aby Z. Philip

previously healthy 68-year-old woman presented with fatigue, night sweats, abdominal fullness, loss of appetite, and low-grade fevers. CT scan of her chest, abdomen, and pelvis revealed diffuse lymphadenopathy involving supraclavicular, axillary, mediastinal

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Richard I. Fisher

/chemotherapy arm experienced more neutropenia and fever; however, overall, treatment discontinuations were similar in both arms: 69% of patients on the R 2 arm and 71% of those on the rituximab/chemotherapy arm completed treatment. 13 Final data showed that R 2

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Radhika Gangaraju, Soo J. Kim, Jing-Fei Dong, Sabina Swierczek, and Josef T. Prchal

, renal dysfunction, and fever. 1 Only a minority of patients present with all of these symptoms, which overlap with other clinical conditions, posing a diagnostic challenge. 2 Acquired TTP occurs due to development of inhibitory antibodies against von