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Geographic Variations of Potentially Curative Treatments for Hepatocellular Carcinoma in the United States: A SEER-Medicare Study

En Cheng, Peiyin Hung, and Shi-Yi Wang

Background Hepatocellular carcinoma (HCC) is the dominant histologic type of liver cancer, affecting approximately 20,000 Americans annually. 1 HCC incidence and mortality have been increasing in the United States during the past 3 decades. 2

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Treatment Options for Merkel Cell Carcinoma

Samuel W. Beenken and Marshall M. Urist

No benefits or funds were received in support of this study. References 1 Toker C . Trabecular carcinoma of the skin . Arch Dermatol 1972 ; 105 : 107 – 110 . 2 Medina-Franco H Urist MM Fiveash J . Multimodality

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Conditional Survival of Patients With Nonmetastatic Renal Cell Carcinoma: How Cancer-Specific Mortality Changes After Nephrectomy

Carlotta Palumbo, Francesco A. Mistretta, Sophie Knipper, Angela Pecoraro, Zhe Tian, Shahrokh F. Shariat, Fred Saad, Claudio Simeone, Alberto Briganti, Alessandro Antonelli, and Pierre I. Karakiewicz

-up have a higher probability of remaining disease-free. 1 However, the magnitude of improved survival is difficult to estimate. Two studies 2 , 3 address cancer-specific CS in patients with nonmetastatic renal cell carcinoma (nmRCC): one is a population

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CRE24-049: Extrapulmonary Small Cell Carcinoma of Gallbladder Presenting as Acute Cholecystitis

Cindy Iwuagwu, Sesha Sai Kanakamedala, Sarah Tinsley, and Jamal Mohsin

Introduction: Small cell carcinoma (SCC) of the gallbladder is a rare and highly aggressive malignancy, characterized by early metastasis and a grim prognosis. Patients often present aggressive symptoms at an advanced stage of the disease

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Patients With cT1N0M0 Oral Squamous Cell Carcinoma Benefit From Elective Neck Dissection: A SEER-Based Study

Alimujiang Wushou, Meng Wang, Feiluore Yibulayin, Lei Feng, Meng-meng Lu, Yuan Luo, Hui Liu, and Zhi-cheng Yang

Background Oral squamous cell carcinoma (OSCC) is among the most common cancers worldwide, with approximately 369,000 new cases reported in 2012, and increasing each year. 1 As presented in the NCCN Clinical Practice Guidelines in

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CRE24-036: Liver-ing on a Prayer: A Rare Case of Hepatocellular Carcinoma With Metastasis to the Thyroid

Rachel Truong, Odelvys Granela, Shelby Ploucher, Alyssa Obermiller, T. Van Anh, Brian Shaw, and Jacqueline N. Kropf

Liver cancer is thought to be the sixth most diagnosed cancer and is among the top five causes of cancer death globally. Hepatocellular carcinoma (HCC) accounts for up to 90% of primary liver neoplasms in adults. The incidence of thyroid

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Biallelic TSC2 Mutations in a Patient With Chromophobe Renal Cell Carcinoma Showing Extraordinary Response to Temsirolimus

Pablo Maroto, Georgia Anguera, Juan Maria Roldan-Romero, Maria Apellániz-Ruiz, Ferran Algaba, Jacqueline Boonman, Mark Nellist, Cristina Montero-Conde, Alberto Cascón, Mercedes Robledo, and Cristina Rodríguez-Antona

Chromophobe renal cell carcinoma (chRCC) is the third most frequent kidney cancer histologic subtype, accounting for approximately 5% of all RCC cases. At diagnosis, chRCC is generally confined to the kidney but can metastasize. At advanced stages

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Liver Transplantation for Hepatocellular Carcinoma: An Update

Jean F. Botha and Alan N. Langnas

. 3. Penn I . Hepatic transplantation for primary and metastatic cancers of the liver . Surgery 1991 ; 110 : 726 – 735 . 4. Iwatsuki S Starzl TE Sheahan DG . Hepatic resection versus transplantation for hepatocellular carcinoma

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Small Cell Lung Cancer

Gregory P. Kalemkerian, Wallace Akerley, Paul Bogner, Hossein Borghaei, Laura Chow, Robert J. Downey, Leena Gandhi, Apar Kishor P. Ganti, Ramaswamy Govindan, John C. Grecula, James Hayman, Rebecca Suk Heist, Leora Horn, Thierry M. Jahan, Marianna Koczywas, Cesar A. Moran, Harvey B. Niell, Janis O'Malley, Jyoti D. Patel, Neal Ready, Charles M. Rudin, and Charles C. Williams Jr.

carcinoma differentiation. This finding is more commonly detected in specimens from previously treated patients and suggests that pulmonary carcinogenesis occurs in a pluripotent stem cell capable of differentiation along divergent pathways. Although 95

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Thyroid Carcinoma

H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida

Although thyroid carcinoma is relatively uncommon, approximately 33,550 new cases will be diagnosed in the United States in 2007. It occurs 2 to 3 times more often in women than in men, and with the incidence increasing by 4% per year, it is currently the eighth most common malignancy diagnosed in women. Although it occurs more often in women, mortality rates are higher for men, probably because they are usually older at the time of diagnosis (65–69 years vs. 50–54 years in women). Interestingly, the incidence of thyroid carcinoma increased almost 240% between 1950 and 2000, but mortality rates decreased more than 44%. Important updates to the 2007 guidelines include revised criteria for categorizing disease, revised recommendation for thyroid-stimulating hormone–stimulated thyroglobulin in some cases, and expanded CT recommendations for anaplastic carcinoma.

For the most recent version of the guidelines, please visit NCCN.org