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Vladislav Berdunov, Gebra Cuyun Carter, Ewan Laws, Roger Luo, Christy Russell, Sara Campbell, Yara Abdou, and Jeremy Force

. As reported in multiple randomized studies including the TAILORx and RxPONDER trials, the Oncotype DX test can identify patients with ER+/HER2- disease who can safely be spared chemotherapy. Furthermore, adjuvant chemotherapy for patients with RS 26

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NCCN Guidelines® Insights: Breast Cancer, Version 4.2021

Featured Updates to the NCCN Guidelines

William J. Gradishar, Meena S. Moran, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H. Allison, Sarah L. Blair, Harold J. Burstein, Chau Dang, Anthony D. Elias, Sharon H. Giordano, Matthew P. Goetz, Lori J. Goldstein, Sara A. Hurvitz, Steven J. Isakoff, Rachel C. Jankowitz, Sara H. Javid, Jairam Krishnamurthy, Marilyn Leitch, Janice Lyons, Jennifer Matro, Ingrid A. Mayer, Joanne Mortimer, Ruth M. O'Regan, Sameer A. Patel, Lori J. Pierce, Hope S. Rugo, Amy Sitapati, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, Erica M. Stringer-Reasor, Melinda L. Telli, John H. Ward, Kari B. Wisinski, Jessica S. Young, Jennifer L. Burns, and Rashmi Kumar

risk of recurrence. Those deemed at high risk for distant recurrence despite adjuvant endocrine therapy may also receive adjuvant chemotherapy. The decision whether to administer adjuvant chemotherapy in patients with HR+/HER2− tumors is based on many

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Presenter: Christopher G. Willett

surgery versus LCCRT, surgery, and adjuvant chemotherapy. 4 With SCRT followed by chemotherapy, the rate of R0 resections (primary endpoint) trended favorably ( P =.07) and acute toxicity was less ( P =.006), but late complications were similar. SCRT also

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Gary H. Lyman

body-mass index . Lancet 2005 ; 366 : 1108 – 1110 . 27 Hershman DL Wang X McBride R . Delay of adjuvant chemotherapy initiation following breast cancer surgery among elderly women . Breast Cancer Res Treat 2006 ; 99 : 313 – 321

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Clayton A. Smith and Lisa A. Kachnic

significant benefit to overall survival (OS). 4 Adjuvant chemotherapy both reduced the rate of distant metastases and improved disease-free survival (DFS). 5 , 6 This review focuses on the current treatment paradigms for LARC and highlights clinical trials

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Danielle S. Graham, Mykola Onyshchenko, Mark A. Eckardt, Benjamin J. DiPardo, Sriram Venigalla, Scott D. Nelson, Bartosz Chmielowski, Arun S. Singh, Jacob E. Shabason, Fritz C. Eilber, and Anusha Kalbasi

benefit in patients treated with multiagent regimens. 16 , 19 There have been no studies to date directly comparing neoadjuvant versus adjuvant chemotherapy, each of which has advantages and disadvantages. Given these data, the NCCN Clinical Practice

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Fei Gao, Nan Li, YongMei Xu, and GuoWang Yang

points. According to the inclusion criteria in our study, we selected patients pathologically diagnosed with stage IIIA non–small cell lung cancer (NSCLC) in 2010 through 2015. According to the NCCN Guidelines, adjuvant chemotherapy is strongly

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Carmen P. Escalante, Ellen Manzullo, and Rosalie Valdres

and correlates of fatigue after adjuvant chemotherapy for breast cancer . J Clin Oncol 1998 ; 16 : 1689 – 1696 . 9 Mendoza TR Wang XS Cleeland CS The rapid assessment of fatigue in cancer patients . Cancer 1999 ; 85 : 1186

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Junmiao Wen and Donglai Chen

into 5 subgroups: surgery alone, surgery plus adjuvant chemotherapy with or without radiotherapy, neoadjuvant chemotherapy with or without radiotherapy plus surgery and adjuvant chemotherapy with or without radiotherapy, concurrent chemoradiotherapy

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Ali Raza Khaki, V.K. Gadi, and Vinay Prasad

Multiple predictive assays have been implemented into clinical practice to help determe which women with early-stage hormone-sensitive breast cancer may benefit from adjuvant chemotherapy and which may not. These assays were originally developed as