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significant benefit to overall survival (OS). 4 Adjuvant chemotherapy both reduced the rate of distant metastases and improved disease-free survival (DFS). 5 , 6 This review focuses on the current treatment paradigms for LARC and highlights clinical trials

benefit in patients treated with multiagent regimens. 16 , 19 There have been no studies to date directly comparing neoadjuvant versus adjuvant chemotherapy, each of which has advantages and disadvantages. Given these data, the NCCN Clinical Practice

points. According to the inclusion criteria in our study, we selected patients pathologically diagnosed with stage IIIA non–small cell lung cancer (NSCLC) in 2010 through 2015. According to the NCCN Guidelines, adjuvant chemotherapy is strongly

into 5 subgroups: surgery alone, surgery plus adjuvant chemotherapy with or without radiotherapy, neoadjuvant chemotherapy with or without radiotherapy plus surgery and adjuvant chemotherapy with or without radiotherapy, concurrent chemoradiotherapy

Multiple predictive assays have been implemented into clinical practice to help determe which women with early-stage hormone-sensitive breast cancer may benefit from adjuvant chemotherapy and which may not. These assays were originally developed as

and correlates of fatigue after adjuvant chemotherapy for breast cancer . J Clin Oncol 1998 ; 16 : 1689 – 1696 . 9 Mendoza TR Wang XS Cleeland CS The rapid assessment of fatigue in cancer patients . Cancer 1999 ; 85 : 1186

adjuvant chemotherapy with or without tamoxifen without irradiation: experience of the Eastern Cooperative Oncology Group . J Clin Oncol 1999 ; 17 : 1689 – 1700 . 3. Jagsi R Raad RA Goldberg S . Locoregional recurrence rates and prognostic

results . Clin Cancer Res 2005 ; 11 [ suppl 13 ]: 4984 – 4987 . 16. Kato H Ichinose Y Ohta M . A randomized trial of adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung . N Engl J Med 2004 ; 350 : 1713 – 1721

results of 20 years of follow-up . N Engl J Med 1995 ; 332 : 901 – 906 . 2 Wood WC Budman DR Korzun AH . Dose and dose intensity of adjuvant chemotherapy for stage II, node-positive breast carcinoma . N Engl J Med 1994 ; 330 : 1253

sarcoma: eight-year experience with adjuvant chemotherapy . J Cancer Res Clin Oncol 1983 ; 106 ( suppl ): 55 – 67 . 16. Sutow WW Sullivan MP Fernbach DJ . Adjuvant chemotherapy in primary treatment of osteogenic sarcoma. A Southwest Oncology