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Maintenance Therapy With Tyrosine Kinase Inhibitors After Transplant in Patients With Chronic Myeloid Leukemia

Merav Bar and Jerald Radich

Therefore, which patients with CML should be considered for allogeneic transplant? Not many. With imatinib, approximately 40% of patients will eventually discontinue therapy, either because of initial failure to achieve milestones, intolerance, or relapse

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NCCN Guidelines® Insights: B-Cell Lymphomas, Version 6.2023

Featured Updates to the NCCN Guidelines

Andrew D. Zelenetz, Leo I. Gordon, Jeremy S. Abramson, Ranjana H. Advani, Babis Andreadis, Nancy L. Bartlett, L. Elizabeth Budde, Paolo F. Caimi, Julie E. Chang, Beth Christian, Sven DeVos, Bhagirathbhai Dholaria, Luis E. Fayad, Thomas M. Habermann, Muhammad Saad Hamid, Francisco Hernandez-Ilizaliturri, Boyu Hu, Mark S. Kaminski, Yasmin Karimi, Christopher R. Kelsey, Rebecca King, Susan Krivacic, Ann S. LaCasce, Megan Lim, Marcus Messmer, Mayur Narkhede, Rachel Rabinovitch, Praveen Ramakrishnan, Erin Reid, Kenneth B. Roberts, Hayder Saeed, Stephen D. Smith, Jakub Svoboda, Lode J. Swinnen, Joseph Tuscano, Julie M. Vose, Mary A. Dwyer, and Hema Sundar

MCL with TP53 mutation, and aids in the selection of appropriate treatment, particularly if up-front HDT/ASCR is anticipated. 10 These NCCN Guidelines Insights discuss recent updates to the management of newly diagnosed and relapsed

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NCCN Guidelines Insights: Non-Hodgkin's Lymphomas, Version 3.2016

Steven M. Horwitz, Andrew D. Zelenetz, Leo I. Gordon, William G. Wierda, Jeremy S. Abramson, Ranjana H. Advani, C. Babis Andreadis, Nancy Bartlett, John C. Byrd, Luis E. Fayad, Richard I. Fisher, Martha J. Glenn, Thomas M. Habermann, Nancy Lee Harris, Francisco Hernandez-Ilizaliturri, Richard T. Hoppe, Mark S. Kaminski, Christopher R. Kelsey, Youn H. Kim, Susan Krivacic, Ann S. LaCasce, Matthew Lunning, Auayporn Nademanee, Oliver Press, Rachel Rabinovitch, Nishitha Reddy, Erin Reid, Kenneth Roberts, Ayman A. Saad, Lubomir Sokol, Lode J. Swinnen, Julie M. Vose, Joachim Yahalom, Nadeem Zafar, Mary Dwyer, Hema Sundar, and Pierluigi Porcu

Second-line systemic therapy followed by HDT/ASCR or allogeneic stem cell transplant (SCT), based on the patient's eligibility for transplant, is the standard treatment approach for patients with relapsed or refractory disease. The management of patients

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Management of Patients With Advanced Melanoma

Presented by: Genevieve Boland

, hazard ratio; Ipi, ipilimumab; Nivo, nivolumab; NR, not reached; Pembro, pembrolizumab; RFS, relapse-free survival. In 2014, the CTLA-4 inhibitor ipilimumab became the first approved immunotherapy for the adjuvant treatment of melanoma, but its

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Updates in Treatment Strategies for Hodgkin Lymphoma

Ranjana H. Advani

Given the myriad of treatment options available for frontline treatment of advanced-stage Hodgkin lymphoma (HL) and for relapsed HL, clinicians must evaluate the advantages and disadvantages of each regimen, balancing risk with benefit for the

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Management of Recurrent Acute Lymphoblastic Leukemia With T-Cell Engagement: CAR T, BiTEs, and Beyond

Jae Park

cell transplant (HSCT). At the NCCN 2019 Annual Congress: Hematologic Malignancies, Jae Park, MD, Associate Attending Physician, Memorial Sloan Kettering Cancer Center, summarized key studies of novel immunotherapies in relapsed/refractory (R/R) ALL and

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NCCN Guidelines Insights: Hodgkin Lymphoma, Version 1.2018

Richard T. Hoppe, Ranjana H. Advani, Weiyun Z. Ai, Richard F. Ambinder, Patricia Aoun, Philippe Armand, Celeste M. Bello, Cecil M. Benitez, Philip J. Bierman, Robert Chen, Bouthaina Dabaja, Robert Dean, Andres Forero, Leo I. Gordon, Francisco J. Hernandez-Ilizaliturri, Ephraim P. Hochberg, Jiayi Huang, Patrick B. Johnston, Mark S. Kaminski, Vaishalee P. Kenkre, Nadia Khan, Kami Maddocks, David G. Maloney, Monika Metzger, Joseph O. Moore, David Morgan, Craig H. Moskowitz, Carolyn Mulroney, Rachel Rabinovitch, Stuart Seropian, Randa Tao, Jane N. Winter, Joachim Yahalom, Jennifer L. Burns, and Ndiya Ogba

the reduction of long-term toxicity. However, 10% to 20% 3 – 6 of patients with favorable features and early-stage disease and up to 30% 7 , 8 with advanced-stage disease experience relapse. The standard treatment option for chemosensitive patients

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Optimizing Treatment Approaches for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Presented by: Jennifer R. Brown

—typically obinutuzumab in the frontline setting and rituximab in the relapsed setting,” Dr. Brown noted at the NCCN 2021 Virtual Congress: Hematologic Malignancies. “But we still, nonetheless, have many unanswered questions.” According to Dr. Brown, current efforts in

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BIO23-022: Adding Virtual Reality Mindful Exposure Therapy to a Cancer Center’s Tobacco Treatment Offerings: An Acceptability Pilot Study

Riley Walton Jackson, Ann Cao-Nasalga, Amy Chieng, Amy Pirkl, Annemarie D. Jagielo, Cindy Tran, Emilio Goldenhersch, Nicolas Rosencovich, Cristian Waitman, and Judith J. Prochaska

50% or more, and two quit for 24-hours then relapsed; 3 (33%) reported some dizziness with app use; 7 of 9 (77%) would recommend MindCotine to a friend. Conclusions: In an acceptability pilot study of a novel VR-MET tobacco treatment app offered to

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Mutation Testing and Adjuvant Systemic Therapy in Cutaneous Melanoma

Anthony J. Olszanski

Patients with stage III melanoma are at high risk for disease recurrence, but adjuvant therapy—including targeted therapy and immunotherapy—may prevent or delay relapse, according to Anthony J. Olszanski, MD, RPh, Associate Professor and Vice Chair