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Pablo Maroto, Georgia Anguera, Juan Maria Roldan-Romero, Maria Apellániz-Ruiz, Ferran Algaba, Jacqueline Boonman, Mark Nellist, Cristina Montero-Conde, Alberto Cascón, Mercedes Robledo, and Cristina Rodríguez-Antona

% of papillary and chromophobe subtypes have mutations in MTOR, TSC1 , or TSC2. 9 – 11 In addition, inactivation of PTEN is frequent in chRCC. Altogether, genomic targeting of the mTOR pathway occurs in 23% of chRCC cases, 11 , 12 suggesting

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Katherine Y. Fan, Avani S. Dholakia, Aaron T. Wild, Zheng Su, Amy Hacker-Prietz, Rachit Kumar, Mary Hodgin, Charles C. Hsu, Dung T. Le, Ana De Jesus-Acosta, Luis A. Diaz Jr, Daniel A. Laheru, Ralph H. Hruban, Elliot K. Fishman, Todd D. Brown, Timothy M. Pawlik, Christopher L. Wolfgang, Phuoc T. Tran, and Joseph M. Herman

), borderline resectable/locally advanced (BL), or metastatic (M) pancreatic cancer, or BPD. Diagnoses considered to be benign disease included autoimmune pancreatitis, intraductal papillary mucinous neoplasm, or pancreatic cyst. Exclusion criteria included

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Peter E. Clark, Neeraj Agarwal, Matthew C. Biagioli, Mario A. Eisenberger, Richard E. Greenberg, Harry W. Herr, Brant A. Inman, Deborah A. Kuban, Timothy M. Kuzel, Subodh M. Lele, Jeff Michalski, Lance C. Pagliaro, Sumanta K. Pal, Anthony Patterson, Elizabeth R. Plimack, Kamal S. Pohar, Michael P. Porter, Jerome P. Richie, Wade J. Sexton, William U. Shipley, Eric J. Small, Philippe E. Spiess, Donald L. Trump, Geoffrey Wile, Timothy G. Wilson, Mary Dwyer, and Maria Ho

tumor is solid (sessile) or high grade, or suggests invasion into muscle, a CT scan or MRI of the abdomen and pelvis is recommended before the TURBT. Because the results of a CT scan rarely alter the management of tumors with a purely papillary

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Mod C. Chandhanayingyong, Nicholas M. Bernthal, Piti Ungarreevittaya, Scott D. Nelson, Sant P. Chawla, and Arun S. Singh

subsequently confirmed with the R130Q mutation in her PTEN gene. In 2008, she had a complete hysterectomy with salpingo-oophorectomy for uterine fibroids, and in 2009 she had a complete thyroidectomy for multicystic adenomatous nodules with focal papillary

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Henry G. Kaplan

present patient. In addition to increased stimulation by RAS, BRAF activity may be increased by the activating BRAF V600E mutation, which has now been identified in several tumor types, including 40% of papillary thyroid cancers, 10% to 65% of

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Stephen A. Brassell and Ashish M. Kamat

: 2050 – 2053 . 66. Rintala E Jauhiainen K Kaasinen E . Alternating mitomycin C and bacillus Calmette-Guerin instillation prophylaxis for recurrent papillary (stages Ta to T1) superficial bladder cancer . J Urol 1996 ; 156 : 56 – 59

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Jennifer M. Weiss, Samir Gupta, Carol A. Burke, Lisen Axell, Lee-May Chen, Daniel C. Chung, Katherine M. Clayback, Susan Dallas, Seth Felder, Olumide Gbolahan, Francis M. Giardiello, William Grady, Michael J. Hall, Heather Hampel, Rachel Hodan, Gregory Idos, Priyanka Kanth, Bryson Katona, Laura Lamps, Xavier Llor, Patrick M. Lynch, Arnold J. Markowitz, Sara Pirzadeh-Miller, Niloy Jewel Samadder, David Shibata, Benjamin J. Swanson, Brittany M. Szymaniak, Georgia L. Wiesner, Andrew Wolf, Matthew B. Yurgelun, Mae Zakhour, Susan D. Darlow, Mary A. Dwyer, and Mallory Campbell

%–10%), thyroid cancer (1%–12%), gastric cancer (0.5%–1.3%), and hepatoblastoma (1%–2%, usually by age 5 years). 11 – 32 Most thyroid cancers seen in FAP are papillary thyroid carcinomas, with the rare cribriform-morular variant considered almost pathognomonic

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Amanda Bennett, Ronald M. Bukowski, Keith Flaherty, J. Cameron Muir, Craig D. Turner, and Sam Donaldson

18th Annual Conference and was joined in a panel discussion by several of her late husband’s physicians. Mr. Foley’s tumor, variously diagnosed as collecting duct carcinoma and papillary renal cell carcinoma, was an incidental finding in 2000

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Letizia Gandolfi, Sarah Adamo, Alessandro Pileri, Alessandro Broccoli, Lisa Argnani, and Pier Luigi Zinzani

BRAF constitutive activation independently of extracellular signals. 15 The BRAF mutation is detected in many malignant diseases, including primary melanoma, hairy cell leukemia, papillary thyroid carcinoma, colorectal cancer, and in approximately

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Srinivas K. Tantravahi, and Theresa L. Werner

% to 7% of uterine tumors. 5 Among epithelial tumors, endometrioid histology is the most common subtype, present in 84% of patients. Poor prognostic subtypes, including papillary serous and clear cell carcinomas, represent the other 6%. 6 Risk factors