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Eric Jonasch

bevacizumab/everolimus is useful in select patients with advanced papillary RCC, including those with germline mutations for hereditary leiomyomatosis and RCC (HLRCC). “I’ve tried this combination and have observed dramatic responses in patients with HLRCC

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Stephen A. Brassell and Ashish M. Kamat

: 2050 – 2053 . 66. Rintala E Jauhiainen K Kaasinen E . Alternating mitomycin C and bacillus Calmette-Guerin instillation prophylaxis for recurrent papillary (stages Ta to T1) superficial bladder cancer . J Urol 1996 ; 156 : 56 – 59

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Mod C. Chandhanayingyong, Nicholas M. Bernthal, Piti Ungarreevittaya, Scott D. Nelson, Sant P. Chawla, and Arun S. Singh

subsequently confirmed with the R130Q mutation in her PTEN gene. In 2008, she had a complete hysterectomy with salpingo-oophorectomy for uterine fibroids, and in 2009 she had a complete thyroidectomy for multicystic adenomatous nodules with focal papillary

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Pablo Maroto, Georgia Anguera, Juan Maria Roldan-Romero, Maria Apellániz-Ruiz, Ferran Algaba, Jacqueline Boonman, Mark Nellist, Cristina Montero-Conde, Alberto Cascón, Mercedes Robledo, and Cristina Rodríguez-Antona

% of papillary and chromophobe subtypes have mutations in MTOR, TSC1 , or TSC2. 9 – 11 In addition, inactivation of PTEN is frequent in chRCC. Altogether, genomic targeting of the mTOR pathway occurs in 23% of chRCC cases, 11 , 12 suggesting

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Victor T.G. Lin, Lisle M. Nabell, Sharon A. Spencer, William R. Carroll, Shuko Harada, and Eddy S. Yang

cancers, including high-grade colorectal neuroendocrine tumors, 22 papillary thyroid carcinoma, 23 and endometrial cancer. 24 To our knowledge, this is the first report of a patient with BRAF -mutated SDC treated with combined BRAF and MEK inhibition

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Katherine Y. Fan, Avani S. Dholakia, Aaron T. Wild, Zheng Su, Amy Hacker-Prietz, Rachit Kumar, Mary Hodgin, Charles C. Hsu, Dung T. Le, Ana De Jesus-Acosta, Luis A. Diaz Jr, Daniel A. Laheru, Ralph H. Hruban, Elliot K. Fishman, Todd D. Brown, Timothy M. Pawlik, Christopher L. Wolfgang, Phuoc T. Tran, and Joseph M. Herman

), borderline resectable/locally advanced (BL), or metastatic (M) pancreatic cancer, or BPD. Diagnoses considered to be benign disease included autoimmune pancreatitis, intraductal papillary mucinous neoplasm, or pancreatic cyst. Exclusion criteria included

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Henry G. Kaplan

present patient. In addition to increased stimulation by RAS, BRAF activity may be increased by the activating BRAF V600E mutation, which has now been identified in several tumor types, including 40% of papillary thyroid cancers, 10% to 65% of

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Mark D. Tyson and Sam S. Chang

that they are at high risk of recurrence compared with those with pT1a tumors. Lastly, metachronous renal tumors in either the ipsilateral or contralateral kidney are found in as many as 20% of patients with papillary RCC or familial RCC. 14 Taken

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Peter E. Clark, Neeraj Agarwal, Matthew C. Biagioli, Mario A. Eisenberger, Richard E. Greenberg, Harry W. Herr, Brant A. Inman, Deborah A. Kuban, Timothy M. Kuzel, Subodh M. Lele, Jeff Michalski, Lance C. Pagliaro, Sumanta K. Pal, Anthony Patterson, Elizabeth R. Plimack, Kamal S. Pohar, Michael P. Porter, Jerome P. Richie, Wade J. Sexton, William U. Shipley, Eric J. Small, Philippe E. Spiess, Donald L. Trump, Geoffrey Wile, Timothy G. Wilson, Mary Dwyer, and Maria Ho

tumor is solid (sessile) or high grade, or suggests invasion into muscle, a CT scan or MRI of the abdomen and pelvis is recommended before the TURBT. Because the results of a CT scan rarely alter the management of tumors with a purely papillary

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Kelly N. Fitzgerald and Chung-Han Lee

later lines of treatment, including sorafenib and tivozanib for ccRCC and erlotinib for papillary RCC. 20 – 22 Among these, cabozantinib is the only TKI monotherapy listed as a preferred option in the NCCN Guidelines for ccRCC (for intermediate