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Wui-Jin Koh, Nadeem R. Abu-Rustum, Sarah Bean, Kristin Bradley, Susana M. Campos, Kathleen R. Cho, Hye Sook Chon, Christina Chu, Rachel Clark, David Cohn, Marta Ann Crispens, Shari Damast, Oliver Dorigo, Patricia J. Eifel, Christine M. Fisher, Peter Frederick, David K. Gaffney, Ernest Han, Warner K. Huh, John R. Lurain III, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W. Remmenga, R. Kevin Reynolds, Todd Tillmanns, Stefanie Ueda, Emily Wyse, Catheryn M. Yashar, Nicole R. McMillian, and Jillian L. Scavone

pelvic control, but not overall survival, and is associated with increased morbidity. 158 A recent Cochrane review examined whether the addition of hysterectomy to standard nonsurgical treatments benefitted women with locally advanced cervical cancer

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Grant A. McArthur

dermatofibrosarcoma protuberans . Br J Dermatol 2004 ; 151 : 235 – 237 . 39. McArthur GA Demetri GD van Oosterom A . Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration

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David B. Shultz, John C. Grecula, James Hayman, Maximilian Diehn, and Billy W. Loo Jr

Small cell lung cancer (SCLC) accounts for approximately 15% of all primary lung cancers 1 and is characterized by an aggressive clinical course. Unfortunately, most patients present with metastatic disease. For patients with locally advanced

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Philip J. Saylor and Matthew R. Smith

-free and overall survival when administered in combination with external beam radiation therapy for locally advanced or high-risk nonmetastatic disease. 8 , 9 Second, ADT is the primary therapy for metastatic disease. With an objective response rate of

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Philippe E. Spiess, Simon Horenblas, Lance C. Pagliaro, Matthew C. Biagioli, Juanita Crook, Peter E. Clark, Richard E. Greenberg, and Cesar E. Ercole

adopting a multimodal approach consisting of neoadjuvant systemic chemotherapy followed by consolidative surgical resection in patients presenting with bulky/locally advanced nodal metastases from penile cancer. In 2013, an estimated 1570 new cases of

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David M. Brizel, William Lydiatt, and A. Dimitrios Colevas

numerically superior to those for the cisplatin-containing regimens. Another small randomized controlled trial of low-dose weekly paclitaxel plus radiation versus weekly cisplatin plus radiation in patients with locally advanced SCCHN showed no statistically

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Lois Ramondetta

as no surprise that these same obstacles prevent women from receiving state-of-the-art supportive care. Treatment of locally advanced disease with radiation often has serious lifelong side effects, including cystitis, proctitis, intestinal

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Ranee Mehra, Candice Yong, Brian Seal, Marjolijn van Keep, Angie Raad, and Yiduo Zhang

84% of all new US lung cancer diagnoses. 3 At diagnosis, approximately 30% of patients with NSCLC have locally advanced stage III disease, many of whom have unresectable tumors. 4 Historically, the prognosis for patients with locally advanced

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Daniëlle D. Huijts, Julia T. van Groningen, Onno R. Guicherit, Jan Willem T. Dekker, Leti van Bodegom-Vos, Esther Bastiaannet, Johannes A. Govaert, Michel W. Wouters, and Perla J. Marang-van de Mheen

or locally advanced tumor. Specific for colon cancer, the pathologic tumor stage and location of the primary tumor were added to the case-mix variables, and specific for rectal cancer, the clinical tumor stage, type of surgery (low anterior resection

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Sherif R. Z. Abdel-Misih, Lai Wei, Al B. Benson III, Steven Cohen, Lily Lai, John Skibber, Neal Wilkinson, Martin Weiser, Deborah Schrag, and Tanios Bekaii-Saab

administered for locally advanced rectal cancer. Patients and Methods NCCN is a not-for-profit alliance comprising 27 of the nation's leading cancer centers whose goal is to improve the quality of multidisciplinary cancer care for patients. NCCN has