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Neoadjuvant Imatinib for Borderline Resectable GIST

M. Zach Koontz, Brendan M. Visser, and Pamela L. Kunz

emergency department with nausea, vomiting, fevers, tachycardia, and an elevated WBC count. CT showed new gas within the tumor, consistent with liquefaction necrosis. She was treated with antibiotics and discharged on continued imatinib. A contrast CT after

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Melanoma, Version 4.2014

Daniel G. Coit, John A. Thompson, Robert Andtbacka, Christopher J. Anker, Christopher K. Bichakjian, William E. Carson III, Gregory A. Daniels, Adil Daud, Dominick DiMaio, Martin D. Fleming, Rene Gonzalez, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr, Mark C. Kelley, Nikhil I. Khushalani, Ragini R. Kudchadkar, Julie R. Lange, Mary C. Martini, Anthony J. Olszanski, Merrick I. Ross, April Salama, Susan M. Swetter, Kenneth K. Tanabe, Vijay Trisal, Marshall M. Urist, Nicole R. McMillian, and Maria Ho

or higher adverse events occurred in 53% of patients receiving dabrafenib, although grade 3 or 4 events were uncommon. The most frequent side effects were skin-related toxicity, fever, fatigue, arthralgia, and headache. Compared with vemurafenib

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Adverse Events Reported by Patients With Cancer After Administration of a 2-Dose mRNA COVID-19 Vaccine

Rebecca M. Shulman, David S. Weinberg, Eric A. Ross, Karen Ruth, Glenn F. Rall, Anthony J. Olszanski, James Helstrom, Michael J. Hall, Julia Judd, David Y.T. Chen, Robert G. Uzzo, Timothy P. Dougherty, Riley Williams, Daniel M. Geynisman, Carolyn Y. Fang, Richard I. Fisher, Marshall Strother, Erica Huelsmann, Sunil Adige, Peter D. Whooley, Kevin Zarrabi, Brinda Gupta, Pritish Iyer, Melissa McShane, Hilario Yankey, Charles T. Lee, Nina Burbure, Lauren E. Laderman, Julie Giurintano, Samuel Reiss, and Eric M. Horwitz

second vaccine dose. Vaccine recipients were asked to report whether they had experienced any of the following symptoms: tiredness, local pain or swelling at the injection site, joint pain, muscle pain, fever, chills, headache, nausea, or an allergic

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BBCIC Research Network Analysis of First-Cycle Prophylactic G-CSF Use in Patients Treated With High–Neutropenia Risk Chemotherapy

Pamala A. Pawloski, Cara L. McDermott, James H. Marshall, Vanita Pindolia, Catherine M. Lockhart, Catherine A. Panozzo, Jeffrey S. Brown, and Bernadette Eichelberger

identification of inpatient FN diagnoses during the first treatment cycle using ICD-9-CM codes in any position based on the following definitions: (1) narrow: a diagnosis of neutropenia (288.0x) and fever (780.6) on the same day; (2) intermediate: neutropenia

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NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities, Version 1.2020

Featured Updates to the NCCN Guidelines

John A. Thompson, Bryan J. Schneider, Julie Brahmer, Stephanie Andrews, Philippe Armand, Shailender Bhatia, Lihua E. Budde, Luciano Costa, Marianne Davies, David Dunnington, Marc S. Ernstoff, Matthew Frigault, Benjamin H. Kaffenberger, Matthew Lunning, Suzanne McGettigan, Jordan McPherson, Nisha A. Mohindra, Jarushka Naidoo, Anthony J. Olszanski, Olalekan Oluwole, Sandip P. Patel, Nathan Pennell, Sunil Reddy, Mabel Ryder, Bianca Santomasso, Scott Shofer, Jeffrey A. Sosman, Yinghong Wang, Ryan M. Weight, Alyse Johnson-Chilla, Griselda Zuccarino-Catania, and Anita Engh

, may indicate colitis . However, blood in the stools and/or fever may be because of other causes of gastrointestinal bleeding, such as infection or peptic ulcer disease or bleeding due to tumor . Cough may be due to an upper respiratory infection

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Treatment Options Expanding for Advanced Melanoma

John A. Thompson

, peritoneal signs consistent with perforation, ileus, fever), permanently discontinue ipilimumab, evaluate for bowel perforation, consider endoscopy, and give steroids until improvement, then taper over 1 month. Incorporating PD1 Inhibitors

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Agents Make “Preferred List” in Metastatic Melanoma

John A. Thompson

combination is clearly better than monotherapy,” Dr. Thompson noted. While the combination protects against squamous cell carcinoma, dual blockade can produce fever and chills that often require temporary treatment cessation, with lower doses on resumption of

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Distress Screening and the Integration of Psychosocial Care Into Routine Oncologic Care

Jimmie C. Holland

), spiritual or religious concerns, and physical problems (eg, breathing problems, constipation, fatigue, fever). Patients can complete the form while in a busy waiting room, and those who have a score of 4 or more (moderate or severe distress) should be

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Major Changes in Systemic Therapy for Advanced Melanoma

John A. Thompson

treated) was a much higher incidence of fever. The newest BRAF/MEK inhibitor combination therapy to receive FDA approval is vemurafenib/cobimetinib. The data behind this approval come from the coBRIM clinical trial. 11 , 12 Larkin et al 11 , 12

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Emerging Therapeutic Options in Acute Lymphoblastic Leukemia

Presented by: Patrick A. Brown

most rapidly within the first week of therapy, which is the high-risk period for CRS,” said Dr. Brown, who noted that CRS is characterized by fever, hypotension, respiratory compromise, and potentially coagulopathy. Neurologic toxicities are the second