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NCCN Roundtable: What Are the Characteristics of an Optimal Clinical Practice Guideline?

David S. Ettinger, Michael Kuettel, Jennifer Malin, Joan S. McClure, Mary Lou Smith, Andrew D. Zelenetz, and F. Marc Stewart

Much has changed in the treatment of cancer since the first NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) were rolled out for 8 different tumor types in November 1996. NCCN Guidelines now include involved algorithms often containing multiple treatment alternatives and detailed pathways of care that depend on more-specific patient characteristics and molecular tumor diagnostics. With 47 different individual NCCN panels, all members of the cancer care team are now better informed than ever to guide patients through the often complex decision-making required to improve the odds of successful outcomes. At the NCCN 20th Annual Conference, a distinguished panel assembled to take a closer look at these invaluable clinical practice guidelines, first glancing backward to how it all started and then forward to explore the key ingredients of trustworthy guidelines.

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KRAS Testing, Tumor Location, and Survival in Patients With Stage IV Colorectal Cancer: SEER 2010–2013

Mary E. Charlton, Amanda R. Kahl, Alissa A. Greenbaum, Jordan J. Karlitz, Chi Lin, Charles F. Lynch, and Vivien W. Chen

, insurance status, marital status, and residence in metropolitan versus nonmetropolitan/rural area. Tumor characteristics included location (right-sided = cecum, ascending colon, hepatic flexure, transverse; vs left-sided = splenic flexure, descending colon

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Mode of Detection of Second Breast Cancers in Patients Undergoing Surveillance After Treatment of Ductal Carcinoma in Situ

Bethany T. Waites, Liisa Lyon, Gillian Kuehner, Patience Odele, Laurel A. Habel, and Raymond Liu

initial DCIS diagnosis. Descriptive statistics (frequencies, medians, quartiles, ranges, and proportions) were used for demographic, clinical characteristics, treatment methods, and follow-up of mammograms and clinic visits. To provide more detail

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Emerging Treatment Options for B-Cell Lymphomas

Andrew D. Zelenetz

highlighted the second-generation BCL-2 inhibitor venetoclax (ABT-199). Early studies with venetoclax have confirmed its activity and the durability of Figure 2 Ideal Characteristics of Immunoconjugates. responses in patients with relapsed

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Prospective Study of Fertility Preservation in Young Women With Breast Cancer in Mexico

Cynthia Villarreal-Garza, Fernanda Mesa-Chavez, Alejandra Plata de la Mora, Melina Miaja-Avila, Marisol Garcia-Garcia, Alan Fonseca, Sylvia de la Rosa-Pacheco, Marlid Cruz-Ramos, Manuel Rolando García Garza, Alejandro Mohar, and Enrique Bargallo-Rocha

). Descriptive statistics were used to analyze the sociodemographic and clinicopathologic characteristics of each group. These variables were then compared between groups using a chi-square test. Simple logistic regression using complete-case analysis was

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Outpatient Management of Pulmonary Embolism in Cancer: Data on a Prospective Cohort of 138 Consecutive Patients

Carme Font, Alberto Carmona-Bayonas, Aranzazu Fernández-Martinez, Carmen Beato, Andrés Vargas, Pere Gascon, and Remedios Otero

negative predictive values (PPV and NPV, respectively); and positive and negative likelihood ratios (pLR and nLR, respectively). The receiver operating characteristic (ROC) curves were calculated, and the method proposed by DeLong et al 23 was used to test

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An Empirical Analysis of Noninferiority Studies in Oncology: Are They Good Enough?

Alyson Haslam, Jennifer Gill, and Vinay Prasad

anecdotally described, 5 , 6 but in light of the increasing rate of publication in these types of studies, we seek to describe the characteristics of a systematic sampling of NI studies in oncology from an updated search of recent published oncology trials

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Paid Sick Leave Among Working Cancer Survivors and Its Associations With Use of Preventive Services in the United States

Zhiyuan Zheng, Stacey A. Fedewa, Farhad Islami, Leticia Nogueira, Xuesong Han, Jingxuan Zhao, Weishan Song, Ahmedin Jemal, and K. Robin Yabroff

, we used nationally representative data to evaluate access to paid sick leave by various sociodemographic/socioeconomic and employment characteristics, which can help identify subgroups of working cancer survivors who are most affected. We also

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EPR24-101: Characteristics of Individuals With Early-Onset GI Cancers in the Southeastern US

Amy F. Ballou, Abbas S. Tavakoli, and Karen E. Wickersham

.72), and alcohol use was (51%). Most were female, 58%, and 49% were African American. Other sociodemographic characteristics included 33% unemployed, and 51% lived in a rural area. About 30% had Medicare/Medicaid insurance, and 4 patients had no insurance

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Increasing Financial Payments From Industry to Medical Oncologists in the United States, 2014–2017

Mohammed W. Rahman, Niti U. Trivedi, Peter B. Bach, and Aaron P. Mitchell

relatively similar proportions of physicians who had graduated <11 years, 11 to 20 years, 21 to 30 years, or >30 years before the study period. Table 1. Physician Characteristics The proportion of oncologists who received any payments within the