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Review of the Role of Opioids in Cancer Pain

Andrea M. Trescot

1. Boyle P . The globalisation of cancer . Lancet 2006 ; 368 : 629 – 630 . 2. van den Beuken-van Everdingen MH de Rijke JM Kessels AG . Prevalence of pain in patients with cancer: a systematic review of the past 40 years . Ann

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Clinical Discussion and Review of the Management of Brain Metastases

Priscilla K. Brastianos, William T. Curry, and Kevin S. Oh

randomized trials address the roles of WBRT and SRS in patients with greater than 4 brain metastases. These conclusions are consistent with those of the evidence-based review 25 and guidelines 26 published by the American Society for Radiation Oncology

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Imatinib-Induced Bone Edema: Case Report and Review of Literature

Lucas Vieira dos Santos, João Paulo Lima, Kathia Cristina Abdalla, Arinilda Campos Bragagnoli, Florinda Almeida Santos, Alexandre dos Anjos Jácome, and Fabiano Elias Porto

journal CE activity: 1) review the learning objectives and author disclosures; 2) study the education content; 3) take the post-test with a 66% minimum passing score and complete the evaluation at http://education.nccn.org/node/30367 ; and 4) view

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A Review of VEGF/VEGFR-Targeted Therapeutics for Recurrent Glioblastoma

David A. Reardon, Scott Turner, Katherine B. Peters, Annick Desjardins, Sridharan Gururangan, John H. Sampson, Roger E. McLendon, James E. Herndon II, Lee W. Jones, John P. Kirkpatrick, Allan H. Friedman, James J. Vredenburgh, Darell D. Bigner, and Henry S. Friedman

studies attempting to more effectively exploit this therapeutic strategy. This article reviews the development, current status, and future challenges of VEGF-targeting therapeutics for patients with recurrent glioblastoma. Angiogenesis in Malignant

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Surgical Management of Colorectal Cancer in the Laparoscopic Era: A Review of Prospective Randomized Trials

Mark Bloomston, Henry Kaufman, John Winston, Mark Arnold, and Edward Martin

The benefits of laparoscopy in benign diseases are quite clear. Patients generally can expect smaller incisions, less narcotic usage, quicker return of bowel function, and shorter hospitalizations. The benefits of laparoscopy in oncologic surgery are less clear, and laparoscopic oncology surgery has many critics. Early reports of long surgical times, high operating room costs, and alarming rates of port-site recurrences after laparoscopic colectomy for colorectal cancer all but stopped this less-invasive approach outside the confines of clinical protocols. As the results of larger retrospective studies began to refute these earlier detrimental claims, prospective randomized trials began to take a foothold. In this article, we review these randomized trials with particular attention to the perioperative effects of laparoscopic colectomy and the short-term oncologic outcomes.

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CRE24-041: Immunotherapy in Older Patients With Breast Cancer: Case Study and Literature Review

Carrie Sha, Marie Liu, Diana Lake, Jasmeet Singh, and Wanqing Iris Zhi

patients treated with immunotherapy and a focused literature review. Case Study: Five older women with TNBC, median age 75 (68–87), received pembrolizumab with chemotherapy at our single institution. Three early-stage TNBC patients received curative

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Seeking Drug Treatment for Oxycontin Abuse: A Chart Review of Consecutive Admissions to a Substance Abuse Treatment Facility in Kentucky

Lon Hays, Kenneth L. Kirsh, and Steven D. Passik

The abuse of prescription opioids has been reported to be on the rise and has gained much public attention, especially given the recent media coverage devoted to the abuse of sustained-release oxycodone (OxyContin, Purdue Pharma LP, Stamford, CT). We tracked admissions to our substance abuse program to put OxyContin abuse into perspective as a presenting problem in the region. A total of 258 admissions to a psychiatric facility for opioid dependence over a 15 month period, for the treatment of prescription opioid abuse, were examined in this chart-review study. A total of 162 patients (62.8%) were admitted for problems related to OxyContin, and the remaining 96 (37.2%) were admitted for abusing other prescription opioids (not including OxyContin). Those abusing OxyContin were found to be younger, more often from a rural background, and more likely to be male compared with those abusing other prescription opioids. In addition, more than half met the criteria for an additional chemical dependency diagnosis and had an additional psychiatric diagnosis. Polysubstance abuse, including OxyContin abuse, was a significant presenting problem to our Addictive Disease Unit between October 2000 and December 2001. Although this chart-review study is not designed to be indicative of the epidemiology of OxyContin abuse, it offers some insight into the nature of this phenomenon in a particular region during the height of public attention paid to it. A follow-up prospective study to examine this phenomenon in multiple regions, further away chronologically from the increased media attention, is underway.

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QIM23-150: Electronic Health Record Alerts Compared to Chart Review for Lung Cancer Screening Eligibility

Alexis Bartley Paulson, Lauren Hatcher, Shanna Joyner, Sarah Valenti, and Kim Sandler

larger quality improvement project to increase lung screening referrals, we examined the efficacy of BPA alerts versus chart review to identify eligible patients. This was part of a larger initiative to improve enrollment of women in lung screening who

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BPI23-008: Accelerating Adoption of Hypofractionation in Breast Cancer Through Clinical Pathways and Peer Review

Sophia Monica Soni, Mark Lorson, Dalissa Kelly, Casey Stockman, and Andrew Hertler

for patients covered by a large, regional Medicaid plan, Neighborhood Health Plan of Rhode Island (Neighborhood), implementation of clinical pathways and prospective peer review was put in place. Methods: This was a retrospective observational study

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BPI21-009: Survival Benefit of Adjuvant Chemotherapy in Pulmonary Carcinoid: A Systematic Review

Philip Sobash and Nagla Abdel Karim

atypical disease and metastatic disease. Aim of the study is to explore the benefit of adjuvant therapy for thoracic carcinoid tumors. Methods: A literature review was conducted through PubMed in accordance with PRISMA guidelines to identify studies