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Novel and Emerging Treatment Strategies for Acute Myeloid Leukemia

Presented by: Eunice S. Wang

-mutant AML (either newly diagnosed or relapsed/refractory) is now standard of care. The phase III RATIFY study performed in younger patients (aged 18–60 years) with newly diagnosed FLT3 -mutant AML found that individuals receiving midostaurin in

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Understanding Causes of Inferior Outcomes in Adolescents and Young Adults With Cancer

Julie A. Wolfson, Kelly M. Kenzik, Blake Foxworthy, John M. Salsman, Katherine Donahue, Marie Nelson, Mary Beth Littrell, Grant R. Williams, and Jennifer M. Levine

their specific needs. When putting AYA outcomes into this context, it is important to consider both patient-level and healthcare-level factors. Several domains in these levels that influence both clinical outcomes (such as relapse and survival) and

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Emerging Therapeutic Options in Acute Lymphoblastic Leukemia

Presented by: Patrick A. Brown

relapsed or refractory disease, various salvage therapies are available, but immunotherapies have produced a paradigm shift in response rates. At the NCCN 2020 Virtual Congress: Hematologic Malignancies, Patrick A. Brown, MD, Professor of Oncology, The

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Updates in the Treatment of Multiple Myeloma

Presented by: Shaji K. Kumar

many new therapies for newly diagnosed and relapsed disease. Despite this, patients continue to relapse, and we continue to try to improve the treatments we use for patients at the time of diagnosis,” he said. Advances in Transplant-Eligible, Newly

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HSR22-171: Health-Related Quality of Life, Symptoms, and Tolerability of Loncastuximab Tesirine in Older Versus Younger Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma Treated in a Phase 2 Clinical Trial (LOTIS-2)

Alexander Spira, Laura Liao, Xiaolei Zhou, Bintu Sherif, Lei Chen, David Ungar, Eric Yu, John Radford, and Mehdi Hamadani

health-related quality of life (HRQOL) in adult patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) after ≥ 2 prior therapies. This analysis evaluates the impact of Lonca on HRQOL, symptoms, and tolerability stratified by age group

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Genomic Instability and Clonal Evolution in Chronic Lymphocytic Leukemia: Clinical Relevance

Adalgisa Condoluci and Davide Rossi

variable (IGHV) genes. 17 Deletions of 17p13/ TP53 mutations occur in 10% of newly diagnosed CLL and progressive CLL requiring first treatment, and in 30% to 40% of cases of relapsed CLL ( Table 1 ). The TP53 gene may be inactivated by deletion and

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Part 1: Abstracts From the NCCN 18th Annual Conference: Advancing the Standard of Cancer Care™

Patients With Relapsed Hodgkin Lymphoma After Autologous Stem Cell Transplant in 5 European Countries Adeline Abbé, a Andrew Lee, a Alaa Hamed, a Frank Neumann, b Robert Olivares, a and Andreas Engert c a Sanofi, Global Evidence and Value

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Survival in Patients With Sentinel Node–Positive Melanoma With Extranodal Extension

Andrea Maurichi, Francesco Barretta, Roberto Patuzzo, Rosalba Miceli, Gianfranco Gallino, Ilaria Mattavelli, Consuelo Barbieri, Andrea Leva, Martina Angi, Francesco Baldo Lanza, Giuseppe Spadola, Mara Cossa, Francesco Nesa, Umberto Cortinovis, Laura Sala, Lorenza Di Guardo, Carolina Cimminiello, Michele Del Vecchio, Barbara Valeri, and Mario Santinami

-rank test. Median follow-up was estimated with the reverse Kaplan-Meier method using OS data. 19 The crude cumulative incidence (CCI) of local relapse, regional relapse, and distant metastasis was estimated in a competing risk setting using cumulative

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Molecular Classification Improves Therapeutic Options for Infants and Young Children With Medulloblastoma

Aditi Bagchi, Sandeep K. Dhanda, Paige Dunphy, Edgar Sioson, and Giles W. Robinson

. However, these therapies had their drawbacks. Those who received focal RT often experienced a metastatic relapse. 29 , 30 The toxicity of HDC-AuSCR was responsible for approximately 10% to 14% of therapy-related deaths. 24 , 25 Leukoencephalopathic

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NCCN Guidelines® Insights: Kidney Cancer, Version 2.2024

Featured Updates to the NCCN Guidelines

Robert J. Motzer, Eric Jonasch, Neeraj Agarwal, Ajjai Alva, Hilary Bagshaw, Michael Baine, Kathryn Beckermann, Maria I. Carlo, Toni K. Choueiri, Brian A. Costello, Ithaar H. Derweesh, Arpita Desai, Yasser Ged, Saby George, John L. Gore, Andrew Gunn, Naomi Haas, Michael Johnson, Payal Kapur, Jennifer King, Christos Kyriakopoulos, Elaine T. Lam, Primo N. Lara, Clayton Lau, Bryan Lewis, David C. Madoff, Brandon Manley, M. Dror Michaelson, Amir Mortazavi, Lee Ponsky, Sundhar Ramalingam, Brian Shuch, Zachary L. Smith, Jeffrey Sosman, Randy Sweis, Matthew Zibelman, Ryan Schonfeld, MaryElizabeth Stein, and Lisa A. Gurski

provide multidisciplinary recommendations for the clinical management of patients with ccRCC and non–clear cell RCC (nccRCC). These NCCN Guidelines Insights focus on the systemic therapy options for patients with relapsed or stage IV advanced RCC