health and functional status associated with older age. 6 , 8 , 9 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer contain 2 age-based treatment concessions. The first is the omission of radiation therapy (RT
Search Results
Receipt of Guideline-Concordant Care Among Older Women With Stage I–III Breast Cancer: A Population-Based Study
Traci LeMasters, S. Suresh Madhavan, Usha Sambamoorthi, Hannah W. Hazard-Jenkins, Kimberly M. Kelly, and Dustin Long
Merkel Cell Carcinoma: A Population Analysis on Survival
Vishwajith Sridharan, Vinayak Muralidhar, Danielle N. Margalit, Roy B. Tishler, James A. DeCaprio, Manisha Thakuria, Guilherme Rabinowits, and Jonathan D. Schoenfeld
, sentinel lymph node biopsy (SLNB), and adjuvant local and regional radiation therapy (RT). 7 , 8 SLNB specifically has become more common during the last decade, potentially impacting staging and treatment. Chemotherapy and concurrent chemoradiation
Smoking Cessation in Patients With Cancer: Treatment Advances and the Oncologist's Role
Paul Cinciripini
treatment, fewer and less serious adverse events (AEs), increased energy, and better quality of life. A recent study found that smoking cessation after stereotactic body radiation therapy improved overall survival in patients with non–small cell lung cancer
Modern Approaches to Localized Cancer of the Esophagus
Robert E. Glasgow, David H. Ilson, James A. Hayman, Hans Gerdes, Mary F. Mulcahy, and Jaffer A. Ajani
significant recent advances in preoperative staging modalities to optimize patient selection for treatment. In addition, treatment algorithms consisting of a combination of chemotherapy, radiation therapy, and surgery have been developed to optimize treatment
Multimodality Approaches to Localized Gastric Cancer
Prajnan Das, Yixing Jiang, Jeffrey H. Lee, Manoop S. Bhutani, William A. Ross, Paul F. Mansfield, and Jaffer A. Ajani
chemoradiation therapy. Chemoradiation consisted of 1 cycle of 5-fluorouracil (5-FU) and leucovorin, followed by radiation therapy (45 Gy) with concurrent bolus 5-FU and leucovorin, followed by 2 more cycles of 5-FU and leucovorin. Patients in the chemoradiation
The Management of Patients With Stage IIIA Non–Small Cell Lung Cancer With N2 Mediastinal Node Involvement
Renato G. Martins, Thomas A. D’Amico, Billy W. Loo Jr, Mary Pinder-Schenck, Hossein Borghaei, Jamie E. Chaft, Apar Kishor P. Ganti, Feng-Ming (Spring) Kong, Mark G. Kris, Inga T. Lennes, and Douglas E. Wood
staging system, 2 the determination of operable stage IIIA (treated with induction therapy followed by surgery) versus inoperable stage IIIA (treated with definitive chemotherapy and radiation therapy) remains controversial. Moreover, some investigators
Treatment De-Intensification for Patients With HPV-Positive Head and Neck Cancers
Presented by: Maura L. Gillison
intensive treatments with induction chemotherapy followed by CRT,” noted Dr. Gillison. At about the same time, a meta-analysis of Radiation Therapy Oncology Group (RTOG) trials, published by Machtay et al, 5 assessed severe late toxicity after concurrent
Role of Molecular Pathology in the Treatment of Anaplastic Gliomas and Glioblastomas
Matthias Holdhoff
-DNA methyltransferase; PCV, procarbazine, lomustine, and vincristine; RT, radiation therapy. better understood as an astrocytoma,” Dr. Holdhoff explained. It is also associated with mutations in IDH, CIC , and FUBP1 . 14 Two randomized prospective trials 5
Management of the Primary Tumor and Limited Metastases in Patients With Metastatic Pancreatic Cancer
Joseph M. Herman, John P. Hoffman, Sarah P. Thayer, and Robert A. Wolff
otherwise be undetected by modern imaging modalities. 1 , 2 Second, a broader array of radiation options that include image-guided (IGRT) and stereotactic body radiation therapy (SBRT) have demonstrated encouraging efficacy in the treatment of primary and
Cervical Cancer
Benjamin E. Greer, Wui-Jin Koh, Nadeem R. Abu-Rustum, Sachin M. Apte, Susana M. Campos, John Chan, Kathleen R. Cho, Larry Copeland, Marta Ann Crispens, Nefertiti DuPont, Patricia J. Eifel, David K. Gaffney, Warner K. Huh, Daniel S. Kapp, John R. Lurain III, Lainie Martin, Mark A. Morgan, Robert J. Morgan Jr., David Mutch, Steven W. Remmenga, R. Kevin Reynolds, William Small Jr., Nelson Teng, and Fidel A. Valea
radiation therapy (RT). Surgery is typically reserved for lower-stage disease and smaller lesions, such as stage IA, IB1, and selected IIA1. The panel agrees that concurrent chemoradiation is the primary treatment of choice for stages IB2 to IVA disease