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Robert E. Glasgow, David H. Ilson, James A. Hayman, Hans Gerdes, Mary F. Mulcahy, and Jaffer A. Ajani

significant recent advances in preoperative staging modalities to optimize patient selection for treatment. In addition, treatment algorithms consisting of a combination of chemotherapy, radiation therapy, and surgery have been developed to optimize treatment

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Prajnan Das, Yixing Jiang, Jeffrey H. Lee, Manoop S. Bhutani, William A. Ross, Paul F. Mansfield, and Jaffer A. Ajani

chemoradiation therapy. Chemoradiation consisted of 1 cycle of 5-fluorouracil (5-FU) and leucovorin, followed by radiation therapy (45 Gy) with concurrent bolus 5-FU and leucovorin, followed by 2 more cycles of 5-FU and leucovorin. Patients in the chemoradiation

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Renato G. Martins, Thomas A. D’Amico, Billy W. Loo Jr, Mary Pinder-Schenck, Hossein Borghaei, Jamie E. Chaft, Apar Kishor P. Ganti, Feng-Ming (Spring) Kong, Mark G. Kris, Inga T. Lennes, and Douglas E. Wood

staging system, 2 the determination of operable stage IIIA (treated with induction therapy followed by surgery) versus inoperable stage IIIA (treated with definitive chemotherapy and radiation therapy) remains controversial. Moreover, some investigators

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Vishwajith Sridharan, Vinayak Muralidhar, Danielle N. Margalit, Roy B. Tishler, James A. DeCaprio, Manisha Thakuria, Guilherme Rabinowits, and Jonathan D. Schoenfeld

, sentinel lymph node biopsy (SLNB), and adjuvant local and regional radiation therapy (RT). 7 , 8 SLNB specifically has become more common during the last decade, potentially impacting staging and treatment. Chemotherapy and concurrent chemoradiation

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Presenter: Maura L. Gillison

intensive treatments with induction chemotherapy followed by CRT,” noted Dr. Gillison. At about the same time, a meta-analysis of Radiation Therapy Oncology Group (RTOG) trials, published by Machtay et al, 5 assessed severe late toxicity after concurrent

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Rihab Melliti, R. Melliti, S. Tbessi, A. Chamsi, H. Ouaz, F. Bouguerra, S. Belajouza, N. Bouzid, and S. Tebra

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Matthias Holdhoff

-DNA methyltransferase; PCV, procarbazine, lomustine, and vincristine; RT, radiation therapy. better understood as an astrocytoma,” Dr. Holdhoff explained. It is also associated with mutations in IDH, CIC , and FUBP1 . 14 Two randomized prospective trials 5

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Joseph M. Herman, John P. Hoffman, Sarah P. Thayer, and Robert A. Wolff

otherwise be undetected by modern imaging modalities. 1 , 2 Second, a broader array of radiation options that include image-guided (IGRT) and stereotactic body radiation therapy (SBRT) have demonstrated encouraging efficacy in the treatment of primary and

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Benjamin E. Greer, Wui-Jin Koh, Nadeem R. Abu-Rustum, Sachin M. Apte, Susana M. Campos, John Chan, Kathleen R. Cho, Larry Copeland, Marta Ann Crispens, Nefertiti DuPont, Patricia J. Eifel, David K. Gaffney, Warner K. Huh, Daniel S. Kapp, John R. Lurain III, Lainie Martin, Mark A. Morgan, Robert J. Morgan Jr., David Mutch, Steven W. Remmenga, R. Kevin Reynolds, William Small Jr., Nelson Teng, and Fidel A. Valea

radiation therapy (RT). Surgery is typically reserved for lower-stage disease and smaller lesions, such as stage IA, IB1, and selected IIA1. The panel agrees that concurrent chemoradiation is the primary treatment of choice for stages IB2 to IVA disease

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Richard Li, Wei-Hsien Hou, Joseph Chao, Yanghee Woo, Scott Glaser, Arya Amini, Rebecca A. Nelson, and Yi-Jen Chen

poor survival outcomes with CRT in the absence of curative surgery, although patients receiving CRT in these studies experienced significant treatment toxicity. 17 – 19 Both chemotherapy and radiation therapy (RT) techniques have advanced significantly