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health and functional status associated with older age. 6 , 8 , 9 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer contain 2 age-based treatment concessions. The first is the omission of radiation therapy (RT

, sentinel lymph node biopsy (SLNB), and adjuvant local and regional radiation therapy (RT). 7 , 8 SLNB specifically has become more common during the last decade, potentially impacting staging and treatment. Chemotherapy and concurrent chemoradiation

treatment, fewer and less serious adverse events (AEs), increased energy, and better quality of life. A recent study found that smoking cessation after stereotactic body radiation therapy improved overall survival in patients with non–small cell lung cancer

significant recent advances in preoperative staging modalities to optimize patient selection for treatment. In addition, treatment algorithms consisting of a combination of chemotherapy, radiation therapy, and surgery have been developed to optimize treatment

chemoradiation therapy. Chemoradiation consisted of 1 cycle of 5-fluorouracil (5-FU) and leucovorin, followed by radiation therapy (45 Gy) with concurrent bolus 5-FU and leucovorin, followed by 2 more cycles of 5-FU and leucovorin. Patients in the chemoradiation

staging system, 2 the determination of operable stage IIIA (treated with induction therapy followed by surgery) versus inoperable stage IIIA (treated with definitive chemotherapy and radiation therapy) remains controversial. Moreover, some investigators

intensive treatments with induction chemotherapy followed by CRT,” noted Dr. Gillison. At about the same time, a meta-analysis of Radiation Therapy Oncology Group (RTOG) trials, published by Machtay et al, 5 assessed severe late toxicity after concurrent

-DNA methyltransferase; PCV, procarbazine, lomustine, and vincristine; RT, radiation therapy. better understood as an astrocytoma,” Dr. Holdhoff explained. It is also associated with mutations in IDH, CIC , and FUBP1 . 14 Two randomized prospective trials 5

otherwise be undetected by modern imaging modalities. 1 , 2 Second, a broader array of radiation options that include image-guided (IGRT) and stereotactic body radiation therapy (SBRT) have demonstrated encouraging efficacy in the treatment of primary and

radiation therapy (RT). Surgery is typically reserved for lower-stage disease and smaller lesions, such as stage IA, IB1, and selected IIA1. The panel agrees that concurrent chemoradiation is the primary treatment of choice for stages IB2 to IVA disease