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Amy Zhou, Manik Amin, Kathryn J. Fowler, Elizabeth M. Brunt, Jesse Keller, and Benjamin Tan

revealed recurrent diffuse omental metastases. She was then restarted on erlotinib and bevacizumab, with prompt resolution of her ascites and abdominal discomfort. Bevacizumab was subsequently held a month after retreatment because of hypertension and chest

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Nicolas Batty, Naveen Yarlagadda, and Roberto Pili

metastases and an irregular tumor protruding into the bladder lumen with bilateral pelvic lymphadenopathy. ADT was initiated with leuprolide, 30 mg, subcutaneously, and bicalutamide, 50 mg, orally daily. A biochemical response occurred, with a nadir PSA of 6

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Joshua K. Sabari, John V. Heymach, and Beth Sandy

with central nervous system metastases. Rates of grade ≥3 adverse events were lower in patients treated with osimertinib versus platinum-pemetrexed chemotherapy. The phase III, double-blind FLAURA trial of osimertinib randomized 556 patients with

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Takashi Taketa, Kazuki Sudo, Arlene M. Correa, Roopma Wadhwa, Hironori Shiozaki, Elena Elimova, Maria-Claudia Campagna, Mariela A. Blum, Heath D. Skinner, Ritsuko U. Komaki, Jeffrey H. Lee, Manoop S. Bhutani, Brian R. Weston, David C. Rice, Stephen G. Swisher, Dipen M. Maru, Wayne L. Hofstetter, and Jaffer A. Ajani

patients had clinical stage II (39.0%) or III (51.7%) cancer. Of the 518 patients, 25 (4.8%) had M1a (celiac lymph node metastases) and were designated clinical stage IVa according to the AJCC 6th edition. 17 Type of Surgery Most of the patients (70

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Louis Burt Nabors, Jana Portnow, Mario Ammirati, Henry Brem, Paul Brown, Nicholas Butowski, Marc C. Chamberlain, Lisa M. DeAngelis, Robert A. Fenstermaker, Allan Friedman, Mark R. Gilbert, Jona Hattangadi-Gluth, Deneen Hesser, Matthias Holdhoff, Larry Junck, Ronald Lawson, Jay S. Loeffler, Paul L. Moots, Maciej M. Mrugala, Herbert B. Newton, Jeffrey J. Raizer, Lawrence Recht, Nicole Shonka, Dennis C. Shrieve, Allen K. Sills Jr, Lode J. Swinnen, David Tran, Nam Tran, Frank D. Vrionis, Patrick Yung Wen, Nicole R. McMillian, and Maria Ho

. Participation in clinical trials is especially encouraged. Overview Metastases to the brain are the most common intracranial tumors in adults and may occur up to 10 times more frequently than primary brain tumors. Population-based data reported that

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Hans F. Schoellhammer, Gagandeep Singh, and Lucille Leong

Presentation A 48-year-old man presented to City of Hope Comprehensive Cancer Center (COHCC) with a diagnosis of rectal adenocarcinoma and synchronous liver metastases. For 1 year, the patient had been experiencing intermittent hematochezia, thinning stool

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Julie R. Gralow, J. Sybil Biermann, Azeez Farooki, Monica N. Fornier, Robert F. Gagel, Rashmi N. Kumar, Charles L. Shapiro, Andrew Shields, Matthew R. Smith, Sandy Srinivas, and Catherine H. Van Poznak

metastases given androgen deprivation therapy . J Urol 2002 ; 167 : 2361 – 2367 ; discussion 2367 . 133 Smith MR McGovern FJ Zietman AL . Pamidronate to prevent bone loss in men receiving gonadotropin releasing hormone agonist therapy for

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Matthew Zibelman and Anthony J. Olszanski

months after initial dose of ipilimumab reveals a marked decrease in size and fludeoxyglucose-avidity of right neck mass and complete resolution of bilateral adrenal and liver metastases (representative images). Discussion This case

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Kelly G. Paulson and Shailender Bhatia

is aggressive, and approximately 37% of patients have nodal or distant spread at presentation ( Figure 1B ); sentinel lymph node evaluation is thus frequently useful to identify subclinical nodal metastases. 4 , 6 Systemic radiologic staging is

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Walburga Yvonne Joko-Fru, Mirko Griesel, Nikolaus Christian Simon Mezger, Lucia Hämmerl, Tobias Paul Seraphin, Jana Feuchtner, Henry Wabinga, Guy N’da, Assefa Mathewos, Bakarou Kamaté, Judith Nsonde Malanda, Freddy Houéhanou Rodrigue Gnangnon, Gladys Chebet Chesumbai, Anne Korir, Cesaltina Lorenzoni, Annelle Zietsman, Margaret Ziona Borok, Biying Liu, Christoph Thomssen, Paul McGale, Ahmedin Jemal, Donald Maxwell Parkin, and Eva Johanna Kantelhardt

were the most commonly used means of screening for metastases. The HRS was recorded for 17.5% of all women and for 27.5% of traced patients. Therapy Characteristics Therapy Received and Guideline Adherence In the population-based cohort, there