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Updates in the Systemic Therapy Options for Clear Cell and Non–Clear Cell Renal Cell Carcinoma

Presented by: Philippe E. Spiess, Peter A.S. Johnstone, and Eric Jonasch

Through the use of case studies, experts in renal cell carcinoma (RCC) explored the latest recommendations in the systemic treatment of patients with clear cell or non–clear cell disease at the NCCN 2023 Annual Conference. This discussion utilized

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Comparative Analysis of Nonalcoholic Steatohepatitis– Versus Viral Hepatitis– and Alcohol-Related Liver Disease–Related Hepatocellular Carcinoma

Caitlin A. Hester, Nicole E. Rich, Amit G. Singal, and Adam C. Yopp

-related liver disease; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; NASH, nonalcoholic steatohepatitis. Clinicopathologic Features Table 1 describes the differences in clinicopathologic features among included patients

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Sex- and Age-Related Differences in the Distribution of Metastases in Patients With Upper Urinary Tract Urothelial Carcinoma

Marina Deuker, Giuseppe Rosiello, Lara Franziska Stolzenbach, Thomas Martin, Claudia Collà Ruvolo, Luigi Nocera, Zhe Tian, Frederik C. Roos, Andreas Becker, Luis A. Kluth, Derya Tilki, Shahrokh F. Shariat, Fred Saad, Felix K.H. Chun, and Pierre I. Karakiewicz

Background Upper tract urothelial carcinoma (UTUC) represents a rare entity, as evidenced by its contribution to only 5% to 10% of urothelial cancers. 1 Due to its rarity, no large-scale observational data are available to describe the

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Frequency, Morbidity, and Mortality of Bone Metastases in Advanced Hepatocellular Carcinoma

James J. Harding, Ghaith Abu-Zeinah, Joanne F. Chou, Dwight Hall Owen, Michele Ly, Maeve Aine Lowery, Marinela Capanu, Richard Do, Nancy E. Kemeny, Eileen M. O'Reilly, Leonard B. Saltz, and Ghassan K. Abou-Alfa

Bone metastases are common in hepatocellular carcinoma (HCC), occurring in 25.5% to 38.5% of patients with extrahepatic disease. 1 – 5 As such, major practice guidelines, including those of NCCN, acknowledge the need to evaluate for HCC bone

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Effect of Preexisting Sarcopenia on Acute and Late Postoperative Pneumonia Among Patients With Oral Cavity Squamous Cell Carcinoma

Yi-Nong Chen, Ching-Wen Chiang, Yu-Hsiang Tsai, Wan-Ming Chen, Mingchih Chen, Ben-Chang Shia, Chun-Chi Huang, and Szu-Yuan Wu

reported. 1 In Taiwan, HNC was the third most common cancer and the fifth leading cause of cancer deaths among men in 2020. 2 Among patients reported to have HNC, most (>80%) have had the oral cavity squamous cell carcinoma (OCSCC) subtype. 3 – 11

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Race- and Sex-Based Disparities in the Therapy and Outcomes of Squamous Cell Carcinoma of the Anus

Nivedita Arora, Arjun Gupta, Hong Zhu, Alana Christie, Jeffrey J. Meyer, Saad A. Khan, and Muhammad S. Beg

decades 2 – 4 : from 0.8 per 100,000 persons in 1975 to 1.9 per 100,000 persons in 2013, with the most rapid increase seen in black men. 5 Squamous cell carcinoma of the anus (SCCA) is the most common histologic subtype of anal cancer, accounting for

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Outcomes of HPV-Associated Squamous Cell Carcinoma of the Head and Neck: Impact of Race and Socioeconomic Status

Luke R.G. Pike, Trevor J. Royce, Amandeep R. Mahal, Daniel W. Kim, William L. Hwang, Brandon A. Mahal, and Nina N. Sanford

Background Squamous cell carcinomas of the head and neck (SCCHNs) are increasing in incidence worldwide. 1 , 2 Contemporary reports have identified HPV infection as a leading risk factor for development of SCCHN, particularly in oropharyngeal

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Implementation of a Voice Messaging System is Associated With Improved Time-to-Treatment and Overall Survival in Patients With Hepatocellular Carcinoma

Ali Mokdad, Travis Browning, John C. Mansour, Hao Zhu, Amit G. Singal, and Adam C. Yopp

transition from hepatocellular carcinoma (HCC) diagnosis to treatment is a complex process involving multiple steps and providers from a multitude of specialties. Unlike many solid organ cancers, HCC is not diagnosed based on tissue biopsy results but rather

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Improved Survival in Contemporary Community-Based Patients With Metastatic Clear-Cell Renal Cell Carcinoma Undergoing Active Treatment

Reha-Baris Incesu, Simone Morra, Lukas Scheipner, Andrea Baudo, Letizia Maria Ippolita Jannello, Mario de Angelis, Carolin Siech, Anis Assad, Zhe Tian, Fred Saad, Shahrokh F. Shariat, Felix K. H. Chun, Alberto Briganti, Ottavio de Cobelli, Luca Carmignani, Sascha Ahyai, Nicola Longo, Derya Tilki, Markus Graefen, and Pierre I. Karakiewicz

Background To date, no population-based study has reported a survival benefit in most contemporary community-based patients with clear-cell metastatic renal cell carcinoma (ccmRCC) receiving active treatment, relative to their historical

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Management of Adrenocortical Carcinoma

Jonathan R. Strosberg, Gary D. Hammer, and Gerard M. Doherty

Edited by Kerrin G. Robinson

, has disclosed no relevant financial relationships. References 1 Dackiw AP Lee JE Gagel RF Evans DB . Adrenal cortical carcinoma . World J Surg 2001 ; 25 : 914 – 926 . 2 Allolio B Fassnacht M . Clinical review