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Presented by: Ronald S. Go

mutations have been found in this population ( Table 1 ). Typically, in those with RDD, BRAF mutations do not occur; however, MAPK pathway gene mutations are common. “Notably, [in] approximately 10% to 20% of cases, the mutations remain unknown,” Dr. Go

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R. Michael Tuttle and R. Leboeuf

Clin Endocrinol Metab 2003 ; 88 : 1947 – 1960 . 20. Shchemelinin I Sefc L Necas E . Protein kinase inhibitors . Folia Biol (Praha) 2006 ; 52 : 137 – 148 . 21. Solit DB Garraway LA Pratilas CA . BRAF mutation predicts

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Karam Khaddour, Michael R. Chicoine, Jiayi Huang, Sonika Dahiya, and George Ansstas

best sensitivity and specificity to detect somatic BRAF mutations in papillary craniopharyngioma, we recommend an approach using DNA-based testing (such as PCR or NGS) and antibody-based testing (immunohistochemistry to detect mutant BRAF protein

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Dwight H. Owen, Bhavana Konda, Jennifer Sipos, Tom Liu, Amy Webb, Matthew D. Ringel, Cynthia D. Timmers, and Manisha H. Shah

the RAS/RAF/MEK/ERK pathway, a key oncogenic signaling cascade for many human malignancies. 3 Activating BRAF mutations are the most common cause for this activation in PTC, occurring in 25% to 49% of tumors. Moreover, the presence of this mutation

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Tanner M. Johanns, Cole J. Ferguson, Patrick M. Grierson, Sonika Dahiya, and George Ansstas

neck (1.4%–3%). 12 , 13 However, it is important to note that BRAF mutations are enriched in some variants of GBM, such as epithelioid GBM, a rare but recently recognized variant of IDH wild-type GBMs. 14 Although epithelioid GBMs often lack the

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Presented by: Dara L. Aisner and Gregory J. Riely

in 5% to 7%, ROS1 rearrangements in 1% to 3%, and BRAF mutations in 2% to 5%. “The best therapeutic outcome is seen if therapy is targeted to the first 3 mutations— EGFR , ALK , and ROS1 . It is critically important to perform testing for

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characteristics, such as microsatellite instability-high (MSI-H), BRAF mutation, or HER2 overexpression. Hereditary risk assessment and screening are also essential components in caring for patients with intestinal cancers, since many are potentially preventable

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develop studies to scientifically evaluate and define GSK2118436, a BRAF inhibitor, and GSK1120212, a MEK1 and MEK2 inhibitor. Previous research has indicated that BRAF mutations are strong targets for therapies in the treatment of advanced melanoma

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rate of combination sorafenib and temsirolimus in I-131 refractory thyroid cancer Secondary Outcome Measures: Evaluate if the presence of BRAF mutations, with or without concomitant mutations in the PI3K AKT, mTOR pathway, predicts

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: Determine the objective response rate of the combination sorafenib and temsirolimus in I-131 refractory thyroid cancer Secondary Outcome Measures: Evaluate if the presence of BRAF mutations, with or without concomitant mutations in the PI3K AKT, mTOR