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CLO24-083: Efficacy of Selinexor in Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis

Junaid Anwar, Muhammad Haseeb, Anusha Baddam, Salma Saidahmed, Binayak Singh, Roshan, Zahoor Ahmed, Ahmed Abdelhakeem, Kachhadia Meet, Raza Zarrar, and Tahir Naqvi

Background: Selinexor is a nuclear exportin-1 (XPO1) inhibitor used for the treatment of acute myeloid leukemia (AML) patients. Selinexor is administered as a monotherapy or in combination with standard chemotherapy. However, the efficacy and

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CLO24-060: Organomegalies as a Predictive Indicator of Leukemia Cutis in the Patients With Acute Myeloid Leukemia

Chalothorn Wannaphut, Chanakarn Kanitthamniyom, Penvadee Pattanaprichakul, Smith Kungwankiatichai, and Weerapat Owattanapanich

Leukemia cutis (LC) is an extramedullary acute myeloid leukemia (AML) infiltrate. No research has outlined the clinical characteristics and outcomes of Thai patients diagnosed with AML who exhibit LC. We conducted a 7-year retrospective case

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NCCN Debuts New Guidelines for Myeloproliferative Neoplasms

Ruben A. Mesa

leukemias that can progress to acute myeloid leukemia (AML) and affect patients in a variety of ways. MPNs are largely driven by key molecular abnormalities, and although they share many features with myelodysplastic syndromes and chronic myeloid leukemia

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New Therapies for Ovarian Cancer

Deborah K. Armstrong

common, but high grades are not. Figure 2. Managing PARPi toxicities: guidelines from Dr. Armstrong's practice. Abbreviations: AML/MDS, acute myeloid leukemia/myelodysplastic syndromes; BP, blood pressure; LFTs, liver function tests; PARPi, PARP

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CLO22-037: Tumor Lysis Syndrome and Infectious Complications During Induction With Venetoclax Combined With Azacitidine or Decitabine in Patients With Acute Myeloid Leukemia

Sankalp Arora, Carl Zainaldin, Srilakshmi Bathini, Udita Gupta, Sarah Worth, Kimo Bachiashvili, Ravi Bhatia, Kelly Godby, Omer Jamy, Sravanti Rangaraju, Barry Diamond, Josh D. Oliver, Donna Salzman, Antonio Di Stasi, and Pankit Vachhani

BACKGROUND : Venetoclax in combination with azacitidine or decitabine(HMA+Ven)is the standard-of-care treatment for older adults(≥75 years) or those with comorbidities precluding intensive induction therapy in newly diagnosed acute myeloid

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EPR24-100: A Comparison of Somatic Mutations and ELN Classification in De Novo Acute Myeloid Leukemia Between Appalachian and Non-Appalachian Kentucky

Zena Chahine, Xitong Zhou, Anna Johnson, Trevor Morris, Ashley Soule, Hiffsa Taj, Claire McAvoy, Chaitanya Iragavarapu, Reinhold Munker, Gregory Monohan, Fevzi Yalniz, Ayman Qasrawi, and Reshma Ramlal

myeloid leukemia (AML) in Appalachian Kentucky (ApK) would have worse outcomes and higher mutational burden compared to patients in non-Appalachian Kentucky (Non-ApK). Methods: A single-center retrospective analysis was done utilizing the Kentucky Cancer

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YIA22-001: Development of hKIT Chimeric Antigen Receptor T-Cells as Dual Hematopoietic Stem Cell Transplantation Conditioning and Immunotherapeutic Agents for Cure of Pediatric Acute Myeloid Leukemia

Quenton Rashawn Bubb, Corey Cheung, Gabriel Eduardo Seir,, Leah Swartzrock, Rebecca Richards, Crystal Mackall, and Agnieszka Czechowicz

Acute myeloid leukemia (AML) is a frequent subtype of cancer that affects thousands of children and adults worldwide. Current treatments generally consist of harsh, conventional chemotherapy and/or hematopoietic stem cell transplantation (HSCT

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NCCN Task Force Report: Evaluating the Clinical Utility of Tumor Markers in Oncology

Phillip G. Febbo, Marc Ladanyi, Kenneth D. Aldape, Angelo M. De Marzo, M. Elizabeth Hammond, Daniel F. Hayes, A. John Iafrate, R. Kate Kelley, Guido Marcucci, Shuji Ogino, William Pao, Dennis C. Sgroi, and Marian L. Birkeland

Biomarkers in Acute Myeloid Leukemia Assays Currently Used in Cancer Care For each disease considered by the task force, including glioma, breast cancer, colon cancer, lung cancer, prostate cancer, and acute myelogenous leukemia, tabular data

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The Role of Myeloid Growth Factors in Acute Leukemia

Martha Wadleigh and Richard M. Stone

previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B study 9720 . Blood 2002 ; 100 : 1224 – 1232 . 3 Stone RM Berg DT George SL . Granulocyte-macrophage colony-stimulating factor after

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Controversies Regarding Use of Myeloid Growth Factors in Leukemia

Jacqueline N. Poston and Pamela S. Becker

Acute Myeloid Leukemia The 2 key goals of myeloid growth factor (MGF) use in the management of acute myeloid leukemia (AML) have been (1) a theoretical benefit for “priming” to improve efficacy of chemotherapy, and (2) reduction of neutropenia