assessed features associated with rapid relapse TNBC (rrTNBC) and found that higher stage at diagnosis, younger age at diagnosis, lower income, and insurance type were significantly associated with rrTNBC. The goal of the present study was to identify
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CLO22-033: Clinicopathologic and Sociodemographic Factors Associated With Late Relapse Triple Negative Breast Cancer
Adith S. Abraham, Carlos H. Barcenas, Richard J. Bleicher, Adam L. Cohen, Sara H. Javid, Ellis G. Levine, Nancy U. Lin, Beverly Moy, Joyce Niland, Antonio C. Wolff, Michael J. Hassett, Daniel G. Stover, and Sarah Asad
NCCN Guidelines® Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 3.2022
Featured Updates to the NCCN Guidelines
William G. Wierda, Jennifer Brown, Jeremy S. Abramson, Farrukh Awan, Syed F. Bilgrami, Greg Bociek, Danielle Brander, Asher A. Chanan-Khan, Steve E. Coutre, Randall S. Davis, Herbert Eradat, Christopher D. Fletcher, Sameh Gaballa, Armin Ghobadi, Muhammad Saad Hamid, Francisco Hernandez-Ilizaliturri, Brian Hill, Paul Kaesberg, Manali Kamdar, Lawrence D. Kaplan, Nadia Khan, Thomas J. Kipps, Shuo Ma, Anthony Mato, Claudio Mosse, Stephen Schuster, Tanya Siddiqi, Deborah M. Stephens, Chaitra Ujjani, Nina Wagner-Johnston, Jennifer A. Woyach, J. Christine Ye, Mary A. Dwyer, and Hema Sundar
Insights discuss the updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for CLL/SLL specific to the use of chemotherapy-free treatment options for patients with previously untreated and relapsed/refractory disease. First
Multiple Successful Desensitizations to Brentuximab Vedotin: A Case Report and Literature Review
Michael D. DeVita, Andrew M. Evens, Steven T. Rosen, Paul A. Greenberger, and Adam M. Petrich
with relapsed sALCL Review the options for desensitization in patients with relapsed or refractory sALCL and hypersensitivity to brentuximab vedotin Case Report A 32-year-old woman with a medical history of super obesity (body mass index
Emerging Therapy for the Treatment of Mantle Cell Lymphoma
Saurabh Rajguru and Brad S. Kahl
consensus exists regarding frontline therapy for MCL, although standards are emerging. The management of relapsed MCL is an area of intense study. This review discusses the current landscape and emerging therapies for MCL in both the front-line and relapsed
HSR23-118: Assessment of Physician Treatment Preferences for Relapsed or Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL)
Wei Gao, Katherine Gaburo, Betsy Lahue, Kalatu Davies, Jon Ukropec, and Monika Jun
CAR T, HCPs estimated that 21.6% of patients were refractory to CAR T and 28.0% relapsed post-CAR T. While 44.0% of HCPs were indifferent to treatment formats, they perceived a large patient preference for subcutaneous (58.7%) versus intravenous (12
NCCN Trends
% reporting a preference for HDT/ASCR consolidation after CHOP+/-R induction. Figure 1 Preferred induction therapy. In the relapsed setting ( Figure 2 ), bendamustine+/-R was the most commonly preferred salvage therapy for oncologists in the
NCCN Guidelines Updates: Discontinuing TKI Therapy in the Treatment of Chronic Myeloid Leukemia
Neil P. Shah
study, the definition was stringent (MR5.0), but further research confirmed that lowering the threshold to a molecular response of 4.5 or 4.0 did not significantly affect rates of molecular relapse ( Figure 1 ). 2 Figure 1. Impact of different molecular
Novel and Emerging Treatment Strategies for Acute Myeloid Leukemia
Presented by: Eunice S. Wang
-mutant AML (either newly diagnosed or relapsed/refractory) is now standard of care. The phase III RATIFY study performed in younger patients (aged 18–60 years) with newly diagnosed FLT3 -mutant AML found that individuals receiving midostaurin in
Understanding Causes of Inferior Outcomes in Adolescents and Young Adults With Cancer
Julie A. Wolfson, Kelly M. Kenzik, Blake Foxworthy, John M. Salsman, Katherine Donahue, Marie Nelson, Mary Beth Littrell, Grant R. Williams, and Jennifer M. Levine
their specific needs. When putting AYA outcomes into this context, it is important to consider both patient-level and healthcare-level factors. Several domains in these levels that influence both clinical outcomes (such as relapse and survival) and
Emerging Therapeutic Options in Acute Lymphoblastic Leukemia
Presented by: Patrick A. Brown
relapsed or refractory disease, various salvage therapies are available, but immunotherapies have produced a paradigm shift in response rates. At the NCCN 2020 Virtual Congress: Hematologic Malignancies, Patrick A. Brown, MD, Professor of Oncology, The