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Brook Blackmore, Nicole Centers, and Troy Gifford

process. Methods: A patient identification software application (patient ID), utilizing natural language processing technology, was developed to identify positive pathology reports across the enterprise in real time. Patient ID instantly routes those

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NCCN Guidelines® Insights: Breast Cancer, Version 4.2021

Featured Updates to the NCCN Guidelines

William J. Gradishar, Meena S. Moran, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H. Allison, Sarah L. Blair, Harold J. Burstein, Chau Dang, Anthony D. Elias, Sharon H. Giordano, Matthew P. Goetz, Lori J. Goldstein, Sara A. Hurvitz, Steven J. Isakoff, Rachel C. Jankowitz, Sara H. Javid, Jairam Krishnamurthy, Marilyn Leitch, Janice Lyons, Jennifer Matro, Ingrid A. Mayer, Joanne Mortimer, Ruth M. O'Regan, Sameer A. Patel, Lori J. Pierce, Hope S. Rugo, Amy Sitapati, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, Erica M. Stringer-Reasor, Melinda L. Telli, John H. Ward, Kari B. Wisinski, Jessica S. Young, Jennifer L. Burns, and Rashmi Kumar

developed by a multidisciplinary panel of representatives from NCCN Member Institutions with breast cancer–focused expertise in the fields of medical oncology, surgical oncology, radiation oncology, pathology, reconstructive surgery, and patient advocacy

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Harry S. Cooper

intestines . In: Atlas of Tumor Pathology , 3rd Series . Washington, DC : Armed Forces Institute of Pathology ; 2003 . 2. Cooper HS . Intestinal neoplasms . In: Mills SE, Carter D, Greenson JK, et al., eds. Sternberg's Diagnostic

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Jeremy S. Abramson

compared with placebo (57% vs 19%) and anemia (61% vs 0%). “Interestingly, this benefit was observed exclusively in patients with the plasmacytic or mixed histologic variants; no patients with hyaline vascular pathology responded to this regimen,” he said

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Kimberly Davies, Matthew Barth, Saro Armenian, Anthony N. Audino, Phillip Barnette, Branko Cuglievan, Hilda Ding, James B. Ford, Paul J. Galardy, Rebecca Gardner, Rabi Hanna, Robert Hayashi, Alexandra E. Kovach, Andrea Judit Machnitz, Kelly W. Maloney, Lianna Marks, Kristin Page, Anne F. Reilly, Joanna L. Weinstein, Ana C. Xavier, Nicole R. McMillian, and Deborah A. Freedman-Cass

-associated BL or DLBCL at this time. This discussion summarizes the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Pediatric Aggressive Mature B-Cell Lymphomas. These guidelines are intended to provide guidance regarding pathology and

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Wui-Jin Koh, Benjamin E. Greer, Nadeem R. Abu-Rustum, Susana M. Campos, Kathleen R. Cho, Hye Sook Chon, Christina Chu, David Cohn, Marta Ann Crispens, Don S. Dizon, Oliver Dorigo, Patricia J. Eifel, Christine M. Fisher, Peter Frederick, David K. Gaffney, Ernest Han, Susan Higgins, Warner K. Huh, John R. Lurain III, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W. Remmenga, R. Kevin Reynolds, Todd Tillmanns, Stefanie Ueda, Fidel A. Valea, Emily Wyse, Catheryn M. Yashar, Nicole McMillian, and Jillian Scavone

Squamous cell vulvar cancers are typically treated with primary surgery, with the potential integration of radiation (RT) and/or chemotherapy based on pathology and extent of disease. 14 Due to the high rates of morbidity with surgical treatment, the field

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L. Stewart Massad

, developed under the leadership of the American Society for Colposcopy and Cervical Pathology (ASCCP) in 2001 and 2006. 16 , 17 By extension, women with similar risk for CIN3 + based on other screening or triage tests also should undergo colposcopy. The

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Jay Gong, Jeffrey P. Gregg, Weijie Ma, Ken Yoneda, Elizabeth H. Moore, Megan E. Daly, Yanhong Zhang, Melissa J. Williams, and Tianhong Li

collapse (solid circle). (C–F) Histologic assessment of different lung pathologies. (C) Hematoxylin-eosin staining revealed LUAD at diagnosis and (D) invasive, well-differentiated, squamous cell carcinoma approximately 3.5 years later at the same location

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Nadeem R. Abu-Rustum and Yukio Sonoda

evidence of metastasis. Sentinel node mapping was performed through cervical injection of blue dye with or without Technetium, as previously described. 14 Pathologic parameters were gathered from the final pathology report. Tumor diameter was estimated

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Jamie E. Flerlage, Susan M. Hiniker, Saro Armenian, Ellen C. Benya, Adam J. Bobbey, Vivian Chang, Stacy Cooper, Don W. Coulter, Branko Cuglievan, Bradford S. Hoppe, Leidy Isenalumhe, Kara Kelly, Leslie Kersun, Adam J. Lamble, Nicole A. Larrier, Jeffrey Magee, Kwadwo Oduro, Martha Pacheco, Anita P. Price, Kenneth B. Roberts, Christine M. Smith, Aliyah R. Sohani, Erin M. Trovillion, Emily Walling, Ana C. Xavier, Jennifer L. Burns, and Mallory Campbell

additional studies such as EBV serology and evaluation for underlying immunodeficiency. For additional information, see “Principles of Pathology” in the algorithm (see PHL-B 1 and 2 of 3, pages 742 and 743). The workup should include a thorough history and