to poor accrual. In the 40 patients studied, survival was significantly longer in the irinotecan arm (median OS, 4.0 vs 2.4 months). Tumor-related symptoms were significantly improved in the experimental arm. Other single agents, such as paclitaxel
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Second-Line Treatment of Advanced Gastric Cancer: Where Do We Stand?
Amit Mahipal, Minsig Choi, and Richard Kim
Real-World Treatment Patterns in Patients With HER2-Amplified Metastatic Colorectal Cancer: A Clinical-Genomic Database Study
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follows: chemotherapy; anti-EGFR therapy ± chemotherapy; anti-VEGF therapy ± chemotherapy; HER2-directed therapy; tipiracil + trifluridine; regorafenib; and non–NCCN-recommended therapies (which included paclitaxel, carboplatin, cisplatin, gemcitabine
Avastin, ODAC, and the FDA: Are We Drafting the Right Players?
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provide confirmatory evidence supporting the original ECOG 2100 study that had led to accelerated approval of bevacizumab in combination with paclitaxel for advanced breast cancer. The FDA will decide in September whether to withdraw the label for the
Practice-Changing Interventions in the Systemic Management of Breast Cancer
Presented by: William J. Gradishar
are given earlier in the course of metastatic disease rather than later, he added. Less frequently, microsatellite instability–high (MSI-H) status can also be exploited with the anti–PD-L1 agent atezolizumab + nab-paclitaxel. The rate NTRK fusions
Surgery After Response to Chemotherapy for Locally Advanced Pancreatic Ductal Adenocarcinoma: A Guide for Management
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horizon for patients with metastatic PDAC significantly changed with the multiagent chemotherapy regimens fluorouracil/folinic acid/irinotecan/oxaliplatin (FOLFIRINOX) 4 and gemcitabine/nab-paclitaxel, 5 respectively. Median survival for patients with
Systemic Therapy for Metastatic or Recurrent Squamous Cell Carcinoma of the Head and Neck
A. Dimitrios Colevas
SCCHN. 9 - 15 The most robustly studied agents are cisplatin, carboplatin, methotrexate, 5-fluorouracil (5-FU), ifosfamide, paclitaxel, and docetaxel ( Table 1 ). Response rates typically range from 10% to 30%, with some outlier reports of higher
Survival After Definitive Chemoradiotherapy With Concurrent Cisplatin or Carboplatin for Head and Neck Cancer
Michael Xiang, A. Dimitrios Colevas, F. Christopher Holsinger, Quynh-Thu X. Le, and Beth M. Beadle
combination chemotherapy ( Figure 2A ), which was predominantly with paclitaxel. By contrast, 86% of patients in the cisplatin cohort received cisplatin monotherapy ( Figure 2B ). H&N CSM was higher for single-agent carboplatin than for multiagent chemotherapy
Identification of Targetable ALK Rearrangements in Pancreatic Ductal Adenocarcinoma
Aatur D. Singhi, Siraj M. Ali, Jill Lacy, Andrew Hendifar, Khanh Nguyen, Jamie Koo, Jon H. Chung, Joel Greenbowe, Jeffrey S. Ross, Marina N. Nikiforova, Herbert J. Zeh, Inderpal S. Sarkaria, Anil Dasyam, and Nathan Bahary
regimens, including gemcitabine plus nab-paclitaxel and FOLFIRINOX (5-fluorouracil, folinic acid, oxaliplatin, and irinotecan), have limited efficacy, with an incremental survival benefit of only a few months in unselected patients. However, significant
SOURCE-PANC: A Prediction Model for Patients With Metastatic Pancreatic Ductal Adenocarcinoma Based on Nationwide Population-Based Data
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: Fluoropyrimidine, platinum, and irinotecan (eg, FOLFIRINOX [5-FU/leucovorin/oxaliplatin/irinotecan]) Regimens with gemcitabine and nab-paclitaxel Gemcitabine monotherapy Other regimens Predictor Preselection Predictors were selected based on
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surveillance CT 6 months later showed disease progression with enlarging lymph nodes. Gemcitabine was reintroduced at a lower dose of 800 mg/m 2 on days 1 and 8 of a 21-day cycle. Nab-paclitaxel was added to gemcitabine from cycle 6 onward because of further
