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Daniel G. Coit, Robert Andtbacka, Christopher J. Anker, Christopher K. Bichakjian, William E. Carson III, Adil Daud, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr., Mark C. Kelley, Nikhil I. Khushalani, Ragini R. Kudchadkar, Julie R. Lange, Anne Lind, Mary C. Martini, Anthony J. Olszanski, Scott K. Pruitt, Merrick I. Ross, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, and Marshall M. Urist

considered. Pathology Report In the revised American Joint Committee of Cancer (AJCC) staging system, patients with melanoma are categorized into 3 groups: localized disease with no evidence of metastases (stage I–II), regional disease (stage III

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Daniel G. Coit, Robert Andtbacka, Christopher K. Bichakjian, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi, Mohammed Kashani-Sabet, Julie R. Lange, Anne Lind, Lainie Martin, Mary C. Martini, Scott K. Pruitt, Merrick I. Ross, Stephen F. Sener, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, Marshall M. Urist, Jeffrey Weber, and Michael K. Wong

lymphadenectomy in patients with sentinel lymph node-positive melanoma . J Clin Oncol 2006 ; 24 : 2858 – 2865 . 24 Gold JS Jaques DP Busam KJ . Yield and predictors of radiologic studies for identifying distant metastases in melanoma patients with a

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Robert J. Downey and Lee M. Krug

Because most patients with small cell cancer of the lung present with distant metastatic disease, the treatment is almost always medical therapies without surgery. However, a small number of patients present with resectable disease, and this review summarizes the available literature addressing the possible role for surgery in the treatment of these patients.

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Steven G. Waguespack and Gary Francis

metastasizes to regional neck lymph nodes. Hematogenous metastases are much less common and generally occur only with significant regional lymph node metastases. 10 , 15 FTC is typically a unifocal tumor and more prone to initial hematogenous metastases to

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Chloe E. Atreya, Claire Greene, Ryan M. McWhirter, Nabia S. Ikram, I. Elaine Allen, Katherine Van Loon, Alan P. Venook, Benjamin M. Yeh, and Spencer C. Behr

, and/or a distinct pattern of metastatic spread. 19 , 23 At diagnosis of mCRC, Yaeger et al 23 found that BRAF -mutated tumors were associated with more frequent peritoneal metastases (26% vs 14%; P <.01) and less frequent liver-limited metastases

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Mustafa Özgüroğlu, Ahmet Sezer, Saadettin Kilickap, Mahmut Gümüş, Igor Bondarenko, Miranda Gogishvili, Xuanyao He, Jennifer McGinniss, Giuseppe Gullo, Petra Rietschel, and Ruben GW Quek

≥50% and clinically stable treated brain metastases at baseline. Post-hoc exploratory analyses were conducted to evaluate PROs in this subgroup of pts. Methods : PROs were assessed at baseline and day 1 of each treatment cycle for the first 6 cycles

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Angela Jain, Paula D. Ryan, and Michael V. Seiden

this point showed that liver metastases had completely calcified without evidence of new disease ( Figure 1 ). With the goal of increasing tumor response, weekly paclitaxel was added to trastuzumab. Over 6 weeks, the CEA continued to trend down to 496

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Rofieda R. Alwaqfi, Megan I. Samuelson, Natalya N. Guseva, Michelle Ouyang, Aaron D. Bossler, and Deqin Ma

pelvis and involving both adnexa (circle). ( B ) Preoperative axial CT images of the upper abdomen show peritoneal carcinomatosis (arrow). ( C ) Coronal CT images show recurrence of disease with multiple hepatic metastases (arrows) and bilateral

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Nadeem R. Abu-Rustum

Incidence of Ultrastage-Detected, Low-Volume Metastases in Sentinel Lymph Nodes According to Final Histologic Grade and Depth of Myometrial Invasion Table 3 Performance of SLN Mapping Alone Compared With the Algorithm for All Patients

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Matthew G. Ewend, David E. Morris, Lisa A. Carey, Alim M. Ladha, and Steven Brem

metastases. Histology, multiplicity, surgery, and survival . Cancer 1996 ; 78 : 1781 – 1788 . 2. Patchell RA Tibbs PA Regine WF . Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial . JAMA 1998