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Ali Bazarbachi, Hamdy A. Azim, Hussain Alizadeh, Mahmoud Aljurf, Ibrahim Barista, Naeem A. Chaudhri, Zahira Fahed, Omar A. Fahmy, Ardeshir Ghavamzadeh, Mohamed H. Khalaf, Sami Khatib, Aghiad Kutoubi, Semra Paydas, Hanadi Rafii Elayoubi, Ghazi Zaatari, Hamdy M. Zawam, and Andrew D. Zelenetz

emergence of infectious diseases, such as hepatitis C virus infections. These malignant lymphomas represent a heterogeneous group of lymphoproliferative malignancies with differing patterns of behavior and responses to treatment. Most non-Hodgkin lymphoma

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En Cheng, Peiyin Hung, and Shi-Yi Wang

-Medicare database. Furthermore, the diagnosis of hepatitis B virus infection (HBV; ICD-9 codes 070.2, 070.3, V02.62), hepatitis C virus infection (HCV; ICD-9 codes 070.41, 070.44, 070.51, 070.54, 070.70, 070.71, V02.62), alcohol-related liver disease (ARLD; ICD-9

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Ali Mokdad, Travis Browning, John C. Mansour, Hao Zhu, Amit G. Singal, and Adam C. Yopp

patient's medical record was performed to obtain patient demographics, clinical history, laboratory data, and imaging results. Clinical history of interest included hepatitis C virus (HCV) and hepatitis B virus (HBV) serostatus, alcohol abuse (defined as

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Hanna K. Sanoff, YunKyung Chang, Joseph M. Stavas, Til Stürmer, and Jennifer Lund

codes for hepatitis B virus, hepatitis C virus, alcoholic cirrhosis, and other cirrhosis. Noncirrhotic comorbidity was determined using the Klabunde modification of the Charlson comorbidity index (CCI). 28 All claims-based covariates were ascertained in

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James J. Harding, Ghaith Abu-Zeinah, Joanne F. Chou, Dwight Hall Owen, Michele Ly, Maeve Aine Lowery, Marinela Capanu, Richard Do, Nancy E. Kemeny, Eileen M. O'Reilly, Leonard B. Saltz, and Ghassan K. Abou-Alfa

Board. Through retrospective chart review, we extracted demographic information (age, sex, race), HCC etiologic factors (eg, hepatitis B virus [HBV] infection, hepatitis C virus [HCV] infection, alcoholic liver disease, nonalcoholic steatohepatitis [NASH

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Ashwin Rao, Nicole E. Rich, Jorge A. Marrero, Adam C. Yopp, and Amit G. Singal

alcohol history, lifetime smoking history, and ECOG performance status. Data regarding liver disease included liver disease etiology (hepatitis C virus [HCV], hepatitis B virus [HBV], alcohol-related liver disease, and nonalcoholic fatty liver disease) 27

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Daniel C. McFarland, Devika R. Jutagir, Andrew H. Miller, William Breitbart, Christian Nelson, and Barry Rosenfeld

of progress and discovery . Brain Behav Immun 2007 ; 21 : 374 – 383 . 17360153 10.1016/j.bbi.2007.01.010 24. Bonaccorso S , Marino V , Biondi M , . Depression induced by treatment with interferon-alpha in patients affected by hepatitis C

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NCCN Guidelines Insights: Hepatobiliary Cancers, Version 2.2019

Featured Updates to the NCCN Guidelines

Al B. Benson III, Michael I. D’Angelica, Daniel E. Abbott, Thomas A. Abrams, Steven R. Alberts, Daniel A. Anaya, Robert Anders, Chandrakanth Are, Daniel Brown, Daniel T. Chang, Jordan Cloyd, Anne M. Covey, William Hawkins, Renuka Iyer, Rojymon Jacob, Andreas Karachristos, R. Kate Kelley, Robin Kim, Manisha Palta, James O. Park, Vaibhav Sahai, Tracey Schefter, Jason K. Sicklick, Gagandeep Singh, Davendra Sohal, Stacey Stein, G. Gary Tian, Jean-Nicolas Vauthey, Alan P. Venook, Lydia J. Hammond, and Susan D. Darlow

carcinoma (HCC) are increasing. 1 , 2 Risk factors for development of HCC include infection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV), and cirrhosis of the liver (eg, alcohol cirrhosis). 3 Metabolic disorders (ie, obesity, diabetes

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Al B. Benson III, Michael I. D'Angelica, Daniel E. Abbott, Thomas A. Abrams, Steven R. Alberts, Daniel A. Anaya, Chandrakanth Are, Daniel B. Brown, Daniel T. Chang, Anne M. Covey, William Hawkins, Renuka Iyer, Rojymon Jacob, Andrea Karachristos, R. Kate Kelley, Robin Kim, Manisha Palta, James O. Park, Vaibhav Sahai, Tracey Schefter, Carl Schmidt, Jason K. Sicklick, Gagandeep Singh, Davendra Sohal, Stacey Stein, G. Gary Tian, Jean-Nicolas Vauthey, Alan P. Venook, Andrew X. Zhu, Karin G. Hoffmann, and Susan Darlow

those caused by hepatitis B virus and/or hepatitis C virus, and cirrhosis from any cause (eg, alcohol cirrhosis). 2 Some nonviral causes include inherited errors of metabolism (relatively rare), such as hereditary hemochromatosis, porphyria cutanea

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Al B. Benson III, Michael I. D’Angelica, Thomas A. Abrams, Chandrakanth Are, P. Mark Bloomston, Daniel T. Chang, Bryan M. Clary, Anne M. Covey, William D. Ensminger, Renuka Iyer, R. Kate Kelley, David Linehan, Mokenge P. Malafa, Steven G. Meranze, James O. Park, Timothy Pawlik, James A. Posey, Courtney Scaife, Tracey Schefter, Elin R. Sigurdson, G. Gary Tian, Jean-Nicolas Vauthey, Alan P. Venook, Yun Yen, Andrew X. Zhu, Karin G. Hoffmann, Nicole R. McMillian, and Hema Sundar

cholangiocarcinoma. 44 Other potential but less-established risk factors include inflammatory bowel disease, hepatitis C virus, hepatitis B virus, cirrhosis, diabetes, obesity, alcohol, and tobacco. Recently, several case-controlled studies from Asian and Western