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Navigating the Challenges: Effective Management of Toxicities in CAR T-Cell Therapies

Presented by: Olalekan O. Oluwole and Salyka Sengsayadeth

inflammatory syndrome characterized by symptoms including fever, flu-like symptoms, and malaise. Severe cases can lead to hemodynamic instability, organ injury or failure, and altered mental status. These on-target effects are induced by binding of the CAR T

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Prevention and Treatment of Cancer-Related Infections

Lindsey Robert Baden, William Bensinger, Michael Angarone, Corey Casper, Erik R. Dubberke, Alison G. Freifeld, Ramiro Garzon, John N. Greene, John P. Greer, James I. Ito, Judith E. Karp, Daniel R. Kaul, Earl King, Emily Mackler, Kieren A. Marr, Jose G. Montoya, Ashley Morris-Engemann, Peter G. Pappas, Ken Rolston, Brahm Segal, Susan K. Seo, Sankar Swaminathan, Maoko Naganuma, and Dorothy A. Shead

); management of neutropenic fever; management of site-specific infections (eg, pneumonia, abdominal infections, catheter-associated infections); and, importantly, prevention of infectious complications, including the use of antimicrobial prophylaxis and

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A Study of Novel Febrile Neutropenia Risk Factors Related to Bone Marrow or Immune Suppression, Barrier Function, and Bacterial Flora

Leila Family, Yanli Li, Lie Hong Chen, John H. Page, Zandra K. Klippel, and Chun Chao

administration in the absence of fever/infection; (3) received dose-dense chemotherapy regimens or weekly regimens; (4) had bone marrow/stem cell transplantation; or (5) were patients of Orange County Medical Center if their cancer was diagnosed before 2007, for

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Brentuximab in the Treatment of CD30-Positive Enteropathy-Associated T-Cell Lymphoma

Waleed F. Khalaf, Meghan E. Caldwell, and Nishitha Reddy

bowel obstruction that was preceded by a few months' history of intermittent diarrhea, fever, and weight loss. Pathology of the small bowel resection was consistent with enteropathy-associated T-cell lymphoma (EATL) that expressed CD3 and CD30; was

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Diagnosis and Management of Castleman Disease

Jeremy S. Abramson

to as idiopathic MCD (iMCD), and is further classified as iMCD-TAFRO (thrombocytopenia, anasarca, fevers, reticulin myelofibrosis, organomegaly) or iMCD-NOS (not otherwise specified). The least common subtype of MCD is POEMS-associated. In addition

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Controversies Regarding Use of Myeloid Growth Factors in Leukemia

Jacqueline N. Poston and Pamela S. Becker

neutrophil recovery and the duration of fever, following induction or consolidation chemotherapy treatment of patients with AML.” 12 The listed side effects, with at least 2% difference in incidence, compared with placebo include epistaxis, back pain, pain

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Real-World Impact of a Decision Support Tool on Colony-Stimulating Factor Use and Chemotherapy-Induced Febrile Neutropenia Among Patients With Breast Cancer

Abiy Agiro, Andrea DeVries, Jennifer Malin, and Michael J. Fisch

FN were identified by the presence of inpatient hospitalization or emergency department (ED) visit with an ICD-9 CM code for neutropenia (288.0) and fever (780.6) using previously validated claims-based algorithms (positive predictive value [PPV], 87

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Unusual Adverse Events in a Patient With BRAF-Mutated Non–Small Cell Lung Cancer Treated With BRAF/MEK Inhibition

Rohan Maniar, Stephanie M. Gallitano, Sameera Husain, Golnaz Moazami, Michael J. Weiss, and Catherine A. Shu

upper extremity. The lesions were intermittent and occasionally accompanied by low-grade fevers. A skin biopsy of the thigh revealed mild perivascular and subcutaneous infiltrate of lymphocytes and few neutrophils consistent with neutrophilic dermatosis

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Management of Immunotherapy-Related Toxicities, Version 1.2022, NCCN Clinical Practice Guidelines in Oncology

John A. Thompson, Bryan J. Schneider, Julie Brahmer, Amaka Achufusi, Philippe Armand, Meghan K. Berkenstock, Shailender Bhatia, Lihua E. Budde, Saurin Chokshi, Marianne Davies, Amro Elshoury, Yaron Gesthalter, Aparna Hegde, Michael Jain, Benjamin H. Kaffenberger, Melissa G. Lechner, Tianhong Li, Alissa Marr, Suzanne McGettigan, Jordan McPherson, Theresa Medina, Nisha A. Mohindra, Anthony J. Olszanski, Olalekan Oluwole, Sandip P. Patel, Pradnya Patil, Sunil Reddy, Mabel Ryder, Bianca Santomasso, Scott Shofer, Jeffrey A. Sosman, Yinghong Wang, Vlad G. Zaha, Megan Lyons, Mary Dwyer, and Lisa Hang

outpatient transplant experience. Hospitalization is warranted for patients at the first sign of CRS or neurotoxicity, including fever, hypotension, or change in mental status. Complete blood count, complete metabolic panel (including magnesium and phosphorus

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Lucky to Be an Oncologist

Harold J. Burstein

scientific factors centered on cancer. A century ago, infectious disease was the specialty du jour. New technologies led to life-changing discoveries: the causes of exotic illnesses like yellow fever; the introduction of antibiotics (or as it was called early