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Accelerated Approval Program Versus NCCN Guidelines as Mechanisms for Early Drug Access

Austin Wesevich and Mark J. Ratain

withdrawal of the indication, the NCCN Guidelines for Breast Cancer 13 continue to recommend bevacizumab in combination with paclitaxel in certain circumstances. We also note that the time to regular approval has been progressively decreasing since 2006

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NCCN News

Trial of Concurrent Nab-Paclitaxel and Cisplatin With Radiotherapy for Locally Advanced Cervical Cancer • Phase II Trial of Trifluridine/Tipiracil in Combination With Irinotecan in Advanced Biliary Tract Cancers • Real-World Data and Independent

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NCCN News

initial testing for all patients. It also includes a number of new recommendations for primary chemotherapy, maintenance treatment, and recurrence treatment. The weekly paclitaxel/carboplatin regimen is a new primary chemotherapy option for all stages

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Part 2: Abstracts from the NCCN 19th Annual Conference: Advancing the Standard of Cancer Care™

%), and ovarian (7%). Hematologic malignancies constituted 11% of the cohort. Single-agent chemotherapy regimens were most common (233 requests), with docetaxel, paclitaxel, gemcitabine, pemetrexed, and fluorouracil totaling 125 requests. Combination

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Ten Years of Progress in Head and Neck Cancers

Shrujal Baxi, Matthew Fury, Ian Ganly, Shyam Rao, and David G. Pfister

therapy before locoregional treatment can improve locoregional control, larynx preservation, and overall survival compared with the use of cisplatin and 5-FU alone as an induction regimen. 21 – 23 The regimen of paclitaxel, cisplatin, and 5-FU also

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A Young Woman With Bilateral Breast Cancer: Identifying a Genetic Cause and Implications for Management

Monique A. de Bruin, James M. Ford, and Allison W. Kurian

weeks with growth factor support, followed by dose-dense paclitaxel on the same schedule; trastuzumab was initiated with paclitaxel, for a planned 1-year course. She underwent bilateral chest wall irradiation and right-sided regional lymph node

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Evolving Treatment Options for Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma

Pelin Cinar and Andrew H. Ko

, 22 in which the combination of gemcitabine and nab-paclitaxel also showed improvements in overall survival when compared with single-agent gemcitabine in patients with metastatic PDAC, likewise should prompt further investigation specific to the

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Rationing Cancer Care: A Survey Among the Members of the German Society of Hematology and Oncology

Stefan W. Krause, Jan Schildmann, Christian Lotze, and Eva C. Winkler

-benefit analysis of bevacizumab in combination with paclitaxel in the first-line treatment of patients with metastatic breast cancer . Breast Cancer Res Treat 2012 ; 132 : 747 - 751 . 19 Lesnock JL Farris C Krivak TC . Consolidation paclitaxel is

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“Standard Care” in Cancer Clinical Trials: An Analysis of Care Provided to Women in the Control Arms of Breast Cancer Clinical Trials

Rachel F. Dear, Kevin McGeechan, Megan B. Barnet, Alexandra L. Barratt, and Martin H.N. Tattersall

, were all in early-stage breast cancer. Of these, 9 used a control group of epirubicin and cyclophosphamide followed by a taxane (either paclitaxel or docetaxel). The point of discordance with the NCCN Guidelines was the choice of anthracycline combined

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Pancreatic Cancer Progression in a Patient With Lynch Syndrome Receiving Immunotherapy: A Cautionary Tale

Yifan Wang, Adeline Cuggia, Alain Pacis, Jean-Christian Boileau, Victoria A. Marcus, Zu-Hua Gao, George Chong, William D. Foulkes, and George Zogopoulos

patient was treated with FOLFIRINOX (5-FU/folinic acid/irinotecan/oxaliplatin), but his disease progressed after 6 cycles ( Figure 1A ). He received gemcitabine/nab-paclitaxel as second-line treatment and experienced a partial response. However, he