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Milestones in the Staging, Classification, and Biology of Merkel Cell Carcinoma

Ata S. Moshiri and Paul Nghiem

staining introduced in the 1990s) ( Figure 1 ). 2 MCC characteristically presents as a solitary pink or purple nodule ( Figure 2 ) that typically has several of the features summarized in the mnemonic “AEIOU”: A symptomatic (eg, painless, nonpruritic), E

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Prognostic and Predictive Value of Blood Tumor Mutational Burden in Patients With Lung Cancer Treated With Docetaxel

Wei Nie, Jie Qian, Mi-Die Xu, Kai Gu, Fang-Fei Qian, Jun Lu, Xue-Yan Zhang, Hui-Min Wang, Bo Yan, Bo Zhang, Shu-Yuan Wang, Fang Hu, Chang-Hui Li, Hua Zhong, and Bao-Hui Han

. Receiver operating characteristic (ROC) curve that plotted sensitivity against 1-specificity of bTMB and rate of DCB was assessed by generating the area under the curve (AUC) for the training set. The accuracy of bTMB for predicting OS was assessed using

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Mortality After Invasive Second Breast Cancers Following Prior Radiotherapy for DCIS

Puyao C. Li, Zilu Zhang, Angel M. Cronin, and Rinaa S. Punglia

the characteristics and prognosis of SBC. Patients and Methods Using the SEER database, 3,407 patients were identified who received BCS ± RT for primary DCIS in 2000 through 2013 and subsequently developed a stage I–III invasive SBC within the same

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Treatment Patterns and Outcomes in Patients With Hepatocellular Carcinoma Stratified by Stage-Guided Treatment Categories

Kuan-Ling Kuo, David Stenehjem, Frederick Albright, Saurabh Ray, and Diana Brixner

at least 2 encounters in the EDW, with 1 encounter at least 30 days from the index date ( Figure 1 , available online, in this article, at JNCCN.org ). Demographic characteristics (age, sex, race, plan type, region) were recorded on index date and

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Patient-Defined Goals and Preferences Among Adults With Advanced Neuroendocrine Tumors

Daneng Li, Can-Lan Sun, Heeyoung Kim, Christiana Crook, Ya-Han Zhang, Rebecca Allen, Richard Ballena, Shadman Hyder, Marianna Koczywas, Vincent Chung, Dean Lim, Vani Katheria, William Dale, and Gagandeep Singh

/treatment characteristics. The proportions and 95% confidence intervals of patients choosing survival, function/independence, freedom from pain, or freedom from symptoms as their most important treatment goal on the Health Outcomes Tool were calculated. Patient opinions on

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Association of Intellectual and Developmental Disabilities With Worse Outcomes After Surgical Treatment of Cancer

Vivian Resende, Selamawit Woldesenbet, Erryk Katayama, Muhammad Musaab Munir, Henrique Araújo Lima, Mujtaba Khalil, Karol Rawicz-Pruszyński, Muhammad Muntazir Mehdi Khan, Usama Waqar, Parit Mavani, Yutaka Endo, and Timothy M. Pawlik

Secondary outcomes of interest included discharge to home (self-care), receipt of chemotherapy after surgery, and mortality. Patient and hospital characteristics were used to describe the cohort. Patient-level characteristics included age, sex, race

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Survival in Patients With Sentinel Node–Positive Melanoma With Extranodal Extension

Andrea Maurichi, Francesco Barretta, Roberto Patuzzo, Rosalba Miceli, Gianfranco Gallino, Ilaria Mattavelli, Consuelo Barbieri, Andrea Leva, Martina Angi, Francesco Baldo Lanza, Giuseppe Spadola, Mara Cossa, Francesco Nesa, Umberto Cortinovis, Laura Sala, Lorenza Di Guardo, Carolina Cimminiello, Michele Del Vecchio, Barbara Valeri, and Mario Santinami

predictors associated with a more aggressive clinical behavior in patients with positive SNs, particularly with regard to metastatic involvement of further non-SNs. Some of these analyses of factors for higher invasiveness focused on characteristics of the

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21-Gene Recurrence Score and Survival Outcomes in the Phase III Multicenter TAILORx Clinical Trial

Sherry X. Yang, John Yu, and Molin Wang

% confidence intervals unsymmetric on the log-ratio scale. Baseline characteristics and median age (range) were compiled with the use of frequency distribution and descriptive statistics. To compare the prognostic information provided by RS regarding BCSS, OS

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Immune-Related Adverse Events Among COVID-19–Vaccinated Patients With Cancer Receiving Immune Checkpoint Blockade

Adam J. Widman, Bevin Cohen, Vivian Park, Tara McClure, Jedd Wolchok, and Mini Kamboj

-agent pembrolizumab. No patients experienced a flare of a prior irAE after vaccination. Table 2 compares characteristics of patients who did versus did not experience an irAE. No significant differences in baseline characteristics or treatment were seen between

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Randomized Trial of a Smartphone Mobile App to Improve Symptoms and Adherence to Oral Therapy for Cancer

Joseph A. Greer, Jamie M. Jacobs, Nicole Pensak, Lauren E. Nisotel, Joel N. Fishbein, James J. MacDonald, Molly E. Ream, Emily A. Walsh, Joanne Buzaglo, Alona Muzikansky, Inga T. Lennes, Steven A. Safren, William F. Pirl, and Jennifer S. Temel

higher scores indicating greater perceived social support. Statistical Analyses SPSS Statistics, version 22.0 (IBM Corp) was used to conduct the analyses. Patient baseline characteristics were described using measures of central tendency or proportions