CD19-directed CAR T-cell therapies for relapsed/refractory B-cell lymphomas. “Given the unprecedented bench-to-bedside clinical success, research and development aimed at refining our existing immunotherapies is proceeding at a very rapid pace,” said
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Update on CAR T-Cell Therapies for Relapsed/Refractory B-Cell Lymphomas
Presented by: Stephen J. Schuster
Optimizing Treatment of Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Presented by: Anthony Mato
The advent of targeted agents for relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) has led to significant improvements in overall survival (OS), progression-free survival (PFS), and quality of life
Biochemical Relapse After Primary Treatment for Prostate Cancer: Studies on Natural History and Therapeutic Considerations
Eli Rosenbaum, Alan Partin, and Mario A. Eisenberger
PSA era . Int J Radiat Oncol Biol Phys 2003 ; 57 : 915 – 928 . 5 Sylvester JE Blasko JC Grimm PD . Ten-year biochemical relapse-free survival after external beam radiation and brachytherapy for localized prostate cancer: the Seattle
An Unusual Presentation of Chronic Myelogenous Leukemia: A Review of Isolated Central Nervous System Relapse
Scott M. Lindhorst, Richard D. Lopez, and Ronald D. Sanders
presented with an isolated central nervous system (CNS) relapse after standard imatinib therapy with good response. Further treatment options, and monitoring of disease response, are discussed. Case Report A 24-year-old otherwise healthy Caucasian
Updates in the Management of CLL/SLL: Management of Relapsed/Refractory Disease and the Role of Minimal Residual Disease
Presented by: Jennifer R. Brown
The landscape of relapsed chronic lymphocytic leukemia (CLL) has changed dramatically over the past few years primarily due to changes in the frontline setting. During the NCCN 2021 Virtual Annual Conference, Jennifer R. Brown, MD, PhD, Director
Review of Late Complications of Treatment and Late Relapse in Testicular Cancer
Eleni Efstathiou and Christopher J. Logothetis
plasma levels and nephrotoxicity . J Clin Oncol 1987 ; 5 : 304 – 309 . 95. Baniel J Foster RS Gonin R . Late relapse of testicular cancer . J Clin Oncol 1995 ; 13 : 1170 – 1176 . 96. George DW Foster RS Hromas RA . Update on
Relapsed/Refractory Diffuse Large B-Cell Lymphoma and Mantle Cell Lymphoma: Is It Time to Consider CAR-T for All?
Presented by: Andrew D. Zelenetz
CAR T cells continue to show impressive activity in relapsed/refractory non-Hodgkin lymphoma, with durable complete responses in a significant percentage of patients with chemorefractory disease. According to Andrew D. Zelenetz, MD, PhD, Medical
Challenges in the Treatment of Newly Diagnosed and Recurrent Primary Central Nervous System Lymphoma
Matthias Holdhoff, Maciej M. Mrugala, Christian Grommes, Thomas J. Kaley, Lode J. Swinnen, Carlos Perez-Heydrich, and Lakshmi Nayak
-MTX) backbone, have demonstrated efficacy in the treatment of newly diagnosed and relapsed or refractory (R/R) PCNSL, but currently there is no consensus on the optimal treatment of these patients. Very few prospective randomized controlled studies have been
Post-Chemoradiation Surgical Pathology Stage Can Customize the Surveillance Strategy in Patients With Esophageal Adenocarcinoma
Takashi Taketa, Kazuki Sudo, Arlene M. Correa, Roopma Wadhwa, Hironori Shiozaki, Elena Elimova, Maria-Claudia Campagna, Mariela A. Blum, Heath D. Skinner, Ritsuko U. Komaki, Jeffrey H. Lee, Manoop S. Bhutani, Brian R. Weston, David C. Rice, Stephen G. Swisher, Dipen M. Maru, Wayne L. Hofstetter, and Jaffer A. Ajani
relapses are common. 7 - 10 After TMT, most patients undergo surveillance for at least 5 years; however, the surveillance recommendations vary considerably and are often empiric in nature. 6 , 10 Relapses seem to be related to the sensitivity of the
Emerging Treatment Options for Acute Lymphoblastic Leukemia: Focus on CAR T-Cell Therapy
Patrick A. Brown and Bijal Shah
Hope remains for patients with acute lymphoblastic leukemia (ALL)—hope to extend life and hope to minimize relapse—according to Patrick A. Brown, MD, and Bijal Shah, MD, who discussed the latest treatment options for ALL during their presentations