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Impact of Immunotherapy on the Survival of Patients With Cancer and Brain Metastases

Saber Amin, Michael Baine, Jane Meza, and Chi Lin

Background Brain metastases (BMs) are the most common intracranial malignancy, occurring in 20% to 40% of all patients with cancer. 1 Each year, >150,000 people are diagnosed with BMs in the United States. 2 The incidence rate of BMs is estimated

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Management of Central Nervous System Tumors

Thomas Kaley and Louis B. Nabors

your practice and we are just beginning to get a better understanding of the natural history of the disease,” he said. Evolving Treatment of Brain Metastases “Brain metastases are the most common type of CNS tumor and appear to be more frequent in some

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Melanoma Metastases to the Adrenal Gland Are Highly Resistant to Immune Checkpoint Inhibitors

Jessica S.W. Borgers, Richard P. Tobin, Robert J. Torphy, Victoria M. Vorwald, Robert J. Van Gulick, Carol M. Amato, Dasha T. Cogswell, Tugs-Saikhan Chimed, Kasey L. Couts, Adrie Van Bokhoven, Christopher D. Raeburn, Karl D. Lewis, Joshua Wisell, Martin D. McCarter, Rao R. Mushtaq, and William A. Robinson

according to the size and location of the metastases, favoring the responses of small lesions and lung metastases. 8 – 10 Interestingly, liver metastases show a differential response based on the extent of CD8+ T-cell tumor infiltration, as well as T

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Chemotherapy for Metastatic Colorectal Cancer

Joseph Rosales and Lucille A. Leong

the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy – an intergroup study . J Clin Oncol 2002 ; 20 : 1499 – 1505 .

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Liver-Directed Therapies in Patients With Advanced Neuroendocrine Tumors

Natalie B. Jones, Manisha H. Shah, and Mark Bloomston

cases of NETs Analyze surgical options for the treatment of liver metastases associated with NETs Assess the use of embolization of liver metastases associated with NETs Evaluate other treatment modalities of liver metastases associated with NETs

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Melanoma

Daniel G. Coit, Robert Andtbacka, Christopher J. Anker, Christopher K. Bichakjian, William E. Carson III, Adil Daud, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr., Mark C. Kelley, Nikhil I. Khushalani, Ragini R. Kudchadkar, Julie R. Lange, Anne Lind, Mary C. Martini, Anthony J. Olszanski, Scott K. Pruitt, Merrick I. Ross, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, and Marshall M. Urist

considered. Pathology Report In the revised American Joint Committee of Cancer (AJCC) staging system, patients with melanoma are categorized into 3 groups: localized disease with no evidence of metastases (stage I–II), regional disease (stage III

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Melanoma

Daniel G. Coit, Robert Andtbacka, Christopher K. Bichakjian, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi, Mohammed Kashani-Sabet, Julie R. Lange, Anne Lind, Lainie Martin, Mary C. Martini, Scott K. Pruitt, Merrick I. Ross, Stephen F. Sener, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, Marshall M. Urist, Jeffrey Weber, and Michael K. Wong

lymphadenectomy in patients with sentinel lymph node-positive melanoma . J Clin Oncol 2006 ; 24 : 2858 – 2865 . 24 Gold JS Jaques DP Busam KJ . Yield and predictors of radiologic studies for identifying distant metastases in melanoma patients with a

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Surgery in the Management of Small Cell Lung Cancer

Robert J. Downey and Lee M. Krug

Because most patients with small cell cancer of the lung present with distant metastatic disease, the treatment is almost always medical therapies without surgery. However, a small number of patients present with resectable disease, and this review summarizes the available literature addressing the possible role for surgery in the treatment of these patients.

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HSR22-134: Outcomes of Patients who Received Radiation Therapy for Brain Metastases From Gynecologic Malignancies

Eric Chen, Todd Aquino-Michaels, Sadhvi Batra, Riley Lochner, Anthony Rizzo, Ravi Kyasaram, Eleanor Harris, Tiffany Hodges, Lindsay Ferguson, and Serah Choi

Background : Even among patients with stage IV gynecologic cancers, metastases to the brain are rare and prognosis remains poor. Given the paucity of data, this study aimed to describe the outcomes of this patient population who underwent

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CLO24-085: Precision Medicine Drivers in Non–Small Cell Lung Cancer Brain Metastases

Catherine Boldig, Kimberly Boldig, Sepideh Mokhtari, and Arnold Etame

Background: Brain metastases (BM) are a leading cause of cancer-related morbidity and mortality, with non–small cell lung cancer (NSCLC) representing one of the most common histology. While radiation therapy has served as the most predominant