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NCCN Guidelines® Insights: Melanoma: Cutaneous, Version 2.2021

Featured Updates to the NCCN Guidelines

Susan M. Swetter, John A. Thompson, Mark R. Albertini, Christopher A. Barker, Joel Baumgartner, Genevieve Boland, Bartosz Chmielowski, Dominick DiMaio, Alison Durham, Ryan C. Fields, Martin D. Fleming, Anjela Galan, Brian Gastman, Kenneth Grossmann, Samantha Guild, Ashley Holder, Douglas Johnson, Richard W. Joseph, Giorgos Karakousis, Kari Kendra, Julie R. Lange, Ryan Lanning, Kim Margolin, Anthony J. Olszanski, Patrick A. Ott, Merrick I. Ross, April K. Salama, Rohit Sharma, Joseph Skitzki, Jeffrey Sosman, Evan Wuthrick, Nicole R. McMillian, and Anita M. Engh

surveillance (where radiologic expertise is available) without completion lymph node dissection, given lack of improved MSS in 2 RCTs assessing the merits of completion lymph node dissection following a positive SLNB vs clinical observation with nodal

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James L. Mohler

. radical prostatectomy vs. external beam radiation vs. brachytherapy) and type of treatment (need for neurovascular bundle resection and/or pelvic lymph node dissection during radical prostatectomy) for clinically localized prostate cancer or adjuvant or

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Shantanu Tyagi, Arandam Roy, Ravimohan Mavuduru, Girdhar Bora, Tushar Aditya Narain, and Arup Kumar Mandal

node dissection, and its extent. Postoperative variables included complications following the surgery (Clavien-Dindo classification), hospital stay, time of indwelling catheter. Follow-up data included serum PSA levels, status of urinary continence

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Brian Badgwell

lymph node dissection based on the CLASSIC and ARTIST trials. 1 , 16 , 17 In the CLASSIC trial, patients in South Korea, China, and Taiwan who had undergone gastrectomy were then randomized to capecitabine plus oxaliplatin for 8 cycles versus no

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Timothy Gilligan, Daniel W. Lin, Rahul Aggarwal, David Chism, Nicholas Cost, Ithaar H. Derweesh, Hamid Emamekhoo, Darren R. Feldman, Daniel M. Geynisman, Steven L. Hancock, Chad LaGrange, Ellis G. Levine, Thomas Longo, Will Lowrance, Bradley McGregor, Paul Monk, Joel Picus, Phillip Pierorazio, Soroush Rais-Bahrami, Philip Saylor, Kanishka Sircar, David C. Smith, Katherine Tzou, Daniel Vaena, David Vaughn, Kosj Yamoah, Jonathan Yamzon, Alyse Johnson-Chilla, Jennifer Keller, and Lenora A. Pluchino

malignancy.” Teratomas with somatic transformation are managed somewhat differently from other nonseminomatous GCTs. For example, stage I transformed teratoma is preferentially managed with retroperitoneal lymph node dissection (RPLND) whereas other stage I

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Steven G. Waguespack and Gary Francis

cervical lymph node involvement. Lymph Node Dissection Lymph node dissection reduces recurrence risk for children with PTC and improves progression-free survival. 69 , 70 The extent of lymph node dissection is based on the type and clinical

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Presenters: Benjamin O. Anderson and Janice A. Lyons

subsets of patients. The appropriate uses of complete axillary lymph node dissection (cALND) and sentinel lymph node biopsy (SLNB) were discussed at the NCCN 2020 Virtual Annual Conference by Benjamin O. Anderson, MD, Professor of Surgery and Global Health

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Daniel G. Coit, Robert Andtbacka, Christopher J. Anker, Christopher K. Bichakjian, William E. Carson III, Adil Daud, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr., Mark C. Kelley, Nikhil I. Khushalani, Ragini R. Kudchadkar, Julie R. Lange, Anne Lind, Mary C. Martini, Anthony J. Olszanski, Scott K. Pruitt, Merrick I. Ross, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, and Marshall M. Urist

lesion. Sentinel Lymph Node Biopsy SLNB is a minimally invasive staging procedure developed to identify patients with subclinical nodal metastases at higher risk of recurrence who could be candidates for complete lymph node dissection or adjuvant

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Daniel G. Coit, Robert Andtbacka, Christopher K. Bichakjian, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi, Mohammed Kashani-Sabet, Julie R. Lange, Anne Lind, Lainie Martin, Mary C. Martini, Scott K. Pruitt, Merrick I. Ross, Stephen F. Sener, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, Marshall M. Urist, Jeffrey Weber, and Michael K. Wong

. Extent of groin dissection for melanoma . Surg Clin North Am 1992 ; 1 : 271 – 280 . 66 Coit DG Brennan MF . Extent of lymph node dissection in melanoma of the trunk or lower extremity . Arch Surg 1989 ; 124 : 162 – 166 . 67

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Ania Syrowatka, James A. Hanley, Daniala L. Weir, William G. Dixon, Ari N. Meguerditchian, and Robyn Tamblyn

-onset psychological distress during both hospital-based treatment and transitional Table 1. Sociodemographic Information, Breast Cancer Characteristics, and Treatments Received (N=16,495) survivorship included younger age, receipt of axillary lymph node