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NCCN Guidelines® Updates: Management of Immunotherapy-Related Toxicities

-cell transplant experience. Close monitoring in the hospital...” ➤ 2nd bullet was revised: “Hospitalization is warranted for patients with at the first sign of CRS or neurotoxicity (including fever, hypotension, or change in mental status) is warranted

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YIA23-003: CD19-CAR T Cells Develop Exhaustion Epigenetic Programs During a Clinical Response

Caitlin Zebley, Charmaine C Brown, Tian Mi, Yiping Fan, Shanta Alli, Shannon Boi, Giovanni Galletti, Enrico Lugli, Deanna Langfitt, Jean-Yves Metais, Timothy Lockey, Michael Meagher, Brandon Triplett, Aimee Talleur, Stephen Gottschalk, and Ben Youngblood

by cross-referencing our epigenetic data with publicly available transcriptional profiles for antigen-specific effector and long-lived memory CD8 T cells from individuals vaccinated for yellow fever. Furthermore, we show that CAR T cells were unable

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Timing of Initial Antibiotic Treatment for Febrile Neutropenia in the Emergency Department: The Need for Evidence-Based Guidelines

Demetrios N. Kyriacou, Borko Jovanovic, and Olga Frankfurt

suppression with resultant leukopenia that renders these patients susceptible to serious infections, often with fever as the only clinical finding. 5 – 8 This complication, known as febrile neutropeni a (FN), occurs in 10% to 30% of patients undergoing

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Counterpoint: Hyperthermia with Radiation Therapy for Chest Wall Recurrences

Beryl McCormick

: Perez CA, Brady LW, eds. Principles and Practices of Radiation Oncology . Philadelphia : J B Lippincott ; 1987 : 317 – 352 . 2. Warren S . Preliminary study of the effect of artificial fever upon hopeless tumor cases . Am J Roentgenol

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Mimicking MacGyver in the Oncology Clinic: Improvisation and Creative Solutions, Only Rarely Involving Duct Tape

David P. Steensma

low-grade fever during the night, and the PICC team’s policy is that all cultures must be negative for 48 hours before a line can be placed. (This scenario is not difficult for me to visualize, since it happened to me twice recently.) You might wait 48

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HSR22-154: Treatment Patterns Following Osimertinib Discontinuation in Patients With EGFR Mutated Metastatic NSCLC

Elizabeth Marrett, Winghan Jacqueline Kwong, Jinlin Song, Ameur M. Manceur, Selvam Sendhil, and Eric Wu

/pneumonitis (3.0), infection/sepsis (2.1), nausea and vomiting (1.9), fever (1.7), and diarrhea (1.5). Conclusions : After osimertinib discontinuation, plat-chemo regimens were the most common subsequent LOT, followed by reuse of EGFR-TKIs. Overall, the

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CLO23-060: Extranodal Presentation of Double Hit High Grade B Cell Lymphoma

Ernesto Munoz and Allison Carilli

. Our patient has a rearrangement of the MYC and BCL-6 oncogenes which is the least common and is considered to have a worse prognosis. HGBL commonly presents with extranodal disease, lymphadenopathy, fever, night sweats, weight loss, loss of appetite

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CLO22-081: Clinical Efficacy and Quality of Life of Oral Cancer Patients Treated With Paclitaxel/Cisplatin/5-FU Vs Paclitaxel/Carboplatin Chemotherapeutic Regimens in a Tertiary Cancer Center in Eastern India

Pranab Kumar Sahoo, Sinjini Sarkar, Sutapa Mahata, Ranita Pal, Tanuma Mistry, Sushmita Ghosh, Trisha Choudhury, Sriparna Datta, Anup Kumar Bhowmick, Kalyan Kusum Mukherjee, and Vilas D Nasare

toxicities like anaemia (13.3%) followed by neutropenia (2.4%) and thrombocytopenia (2.4%) whereas non-hematological toxicities include diarrhoea (30.5%), vomiting (26.6%), fever (23.1%), myalgia (19.7%) and mucositis (5.41%). 82 (40.39%) patients succumbed

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Navigating the Challenges: Effective Management of Toxicities in CAR T-Cell Therapies

Presented by: Olalekan O. Oluwole and Salyka Sengsayadeth

inflammatory syndrome characterized by symptoms including fever, flu-like symptoms, and malaise. Severe cases can lead to hemodynamic instability, organ injury or failure, and altered mental status. These on-target effects are induced by binding of the CAR T

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Prevention and Treatment of Cancer-Related Infections

Lindsey Robert Baden, William Bensinger, Michael Angarone, Corey Casper, Erik R. Dubberke, Alison G. Freifeld, Ramiro Garzon, John N. Greene, John P. Greer, James I. Ito, Judith E. Karp, Daniel R. Kaul, Earl King, Emily Mackler, Kieren A. Marr, Jose G. Montoya, Ashley Morris-Engemann, Peter G. Pappas, Ken Rolston, Brahm Segal, Susan K. Seo, Sankar Swaminathan, Maoko Naganuma, and Dorothy A. Shead

); management of neutropenic fever; management of site-specific infections (eg, pneumonia, abdominal infections, catheter-associated infections); and, importantly, prevention of infectious complications, including the use of antimicrobial prophylaxis and