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Cancer-Related Fatigue

St. Jude Children's Research Hospital

Fatigue is a common symptom in patients with cancer and is nearly universal in those undergoing cytotoxic chemotherapy, radiation therapy, bone marrow transplantation, or treatment with biologic response modifiers. The problem, which affects 70% to 100% of cancer patients, has been exacerbated by the increased use of fatigue-inducing multimodal treatments and dose-dense, dose-intense protocols. In patients with metastatic disease, the prevalence of cancer-related fatigue exceeds 75%, and cancer survivors report that fatigue is a disruptive symptom months or even years after treatment ends. Patients perceive fatigue to be the most distressing symptom associated with cancer and its treatment, more distressing even than pain or nausea and vomiting, which, for most patients, can generally be managed with medications.

For the most recent version of the guidelines, please visit NCCN.org

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Sleep Disorders, Fatigue, and Cognitive Function in Cancer Survivors: A Plenary Session

Presented by: Kristin Dickinson, Halle C.F. Moore, Jennifer Schmitz, and Eric S. Zhou

Moderated by: Andrew T. Day

Sleep disorders (particularly insomnia), cancer-related fatigue, and cancer-related cognitive impairment are common and distressing symptoms of cancer and its treatment. A plenary discussion on this topic at the NCCN 2023 Annual Conference

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Complications of Multiple Myeloma Therapy, Part 1: Risk Reduction and Management of Peripheral Neuropathy and Asthenia

Paul G. Richardson, Jacob P. Laubach, Robert L. Schlossman, Constantine Mitsiades, and Kenneth Anderson

Peripheral neuropathy (PN) and asthenia (fatigue) are among the most commonly seen complications in patients undergoing multiple myeloma (MM) therapy. These potentially debilitating adverse effects are frequently dose limiting, and they may

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Health-Related Quality of Life in Patients With Metastatic Colorectal Cancer Undergoing Systemic Therapy With or Without Maximal Tumor Debulking

Lotte Bakkerus, Laurien M. Buffart, Tineke E. Buffart, Yannick M. Meyer, Barbara M. Zonderhuis, Cornelis J.A. Haasbeek, Kathelijn S. Versteeg, Olaf J.L. Loosveld, Jan Willem B. de Groot, Mathijs P. Hendriks, Cornelis Verhoef, Hendrik M.W. Verheul, and Elske C. Gootjes

investigated using the EORTC Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). 29 , 30 This questionnaire consists of 5 functional scales (physical, social, role, cognitive, and emotional functioning), 3 symptom scales (fatigue, pain, and nausea

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Cancer-Related Fatigue Clinical Practice Guidelines in Oncology

The problem of cancer-related fatigue, which affects 70% to 100% of cancer patients, has been exacerbated by the increased use of fatigue-inducing multimodal treatments and dose-dense, dose-intense protocols. In patients with metastatic disease, the prevalence of cancer-related fatigue exceeds 75%, and cancer survivors report that fatigue is a disruptive symptom months or even years after treatment ends. To address the significant problem of cancer-related fatigue, the NCCN convened a panel of experts in the field of fatigue. The Cancer-Related Fatigue Clinical Practice Guidelines synthesize the available research and clinical experience in this field and provide recommendations for patient care.

For the most recent version of the guidelines, please visit NCCN.org

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Cancer Patient Survival and Erythropoietin

John A. Glaspy

anemic cancer patients when referenced to the general population . J Clin Oncol 2003 ; 21 : 366 – 373 . 2 Cella D Kallich J McDermott A Xu X . The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer

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Erythropoiesis-Stimulating Agents in Oncology

John A. Glaspy

X . The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from five randomized clinical trials . Ann Oncol 2004 ; 15 : 979 – 986 . 6. Berndt E Kallich J McDermott A . Reductions in

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Letter to the Editor: Panax Ginseng for Cancer-Related Fatigue

Andrea Angelo Martoni, Luigi Cavanna, and Gianpiero Porzio

Re: Sriram Yennurajalingam, Nizar M. Tannir, Janet L. Williams, et al. A Double-Blind, Randomized, Placebo-Controlled Trial of Panax Ginseng for Cancer-Related Fatigue in Patients With Advanced Cancer. J Natl Compr Canc Netw 2017

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Compound Kushen Injection Reduces Severe Toxicity and Symptom Burden Associated With Curative Radiotherapy in Patients With Lung Cancer

Jie Liu, Qingxi Yu, Xin Shelley Wang, Qiuling Shi, Jun Wang, Fan Wang, Simeng Ren, Jiayue Jin, Baojin Han, Wenzheng Zhang, Xueyao Su, Shuanghu Yuan, and Hongsheng Lin

developed in clinical practice in China based on TCM theory. Patients undergoing RT usually demonstrate a cluster of symptoms (eg, cough, dyspnea, fatigue, and pain) that are related to inflammation or ulceration, which may be diagnosed as a heat toxin

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Dissemination and Implementation of Guidelines for Cancer-Related Fatigue

Ann M. Berger and Kathi Mooney

Evidence-based recommendations for cancer-related fatigue (CRF) have been disseminated recently by all major cancer organizations (NCCN, Oncology Nursing Society [ONS], Canadian Partnership Against Cancer/Canadian Association of Psychosocial