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Treatment Updates in Acute Myeloid Leukemia

Presented by: Alexander E. Perl

, such as gemtuzumab ozogamicin (GO) added to induction and consolidation therapy for those with CBF leukemias, liposomal formulations for older patients with secondary leukemias, and the addition of midostaurin for those with FLT3 mutations. “It is

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Acute Myeloid Leukemia, Version 2.2013

Margaret R. O’Donnell, Martin S. Tallman, Camille N. Abboud, Jessica K. Altman, Frederick R. Appelbaum, Daniel A. Arber, Eyal Attar, Uma Borate, Steven E. Coutre, Lloyd E. Damon, Jeffrey Lancet, Lori J. Maness, Guido Marcucci, Michael G. Martin, Michael M. Millenson, Joseph O. Moore, Farhad Ravandi, Paul J. Shami, B. Douglas Smith, Richard M. Stone, Stephen A. Strickland, Eunice S. Wang, Kristina M. Gregory, and Maoko Naganuma

synergistically with ATRA. 13 , 14 The addition of ATO as first-line consolidation therapy with ATRA and anthracycline (following standard induction with ATRA, anthracycline, and cytarabine) resulted in improved outcomes in the North American Intergroup trial. 9

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Metastatic Anal Carcinoma: The Role of Radiotherapy

Yi-Jen Chen

for patients with MAC, the SABR-COMET trial by Palma et al 8 and the study of local consolidative therapy in oligometastatic non–small cell lung cancer by Gomez et al 9 have shown a positive role for aggressive local therapy, including stereotactic

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Oncology Research Program

OS Evaluate the ability of the induction and consolidation therapy to get 70% of patients to ASCT Evaluate the tolerability and CD34+ cell yield after therapy with patient and hyperfractionated cyclophosphamide, doxorubicin, vincristine, and

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Oncology Research Program

measured at baseline and at the end of first ofatumumab infusion with ORR, CRR, MRD, TTP, PFS, and OS Evaluate the ability of the induction and consolidation therapy to get 70% of patients to ASCT Evaluate the tolerability and CD34+ cell yield

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Oncology Research Program

/refractory tumor specimens Correlate serum C3, C4, and CH50 levels measured at baseline and at the end of first ofatumumab infusion with ORR, CRR, MRD, TTP, PFS, and OS Evaluate the ability of the induction and consolidation therapy to obtain 70% of patients to

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The Role of Transplant in Multiple Myeloma

Matthew Mei and George Somlo

ASCT followed by maintenance, single ASCT followed by both PI- and IMiD-containing consolidation therapy and then maintenance, or tandem ASCT followed by maintenance, has just completed accrual and will likely clarify the feasibility and role of tandem

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Growth Factors in Leukemia

Olga Frankfurt and Martin S. Tallman

, double-blind, placebo-controlled, phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia . The International Acute Myeloid Leukemia Study Group . Blood 1997 ; 90 : 4710 – 4718

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NCCN News

of Texas MD Anderson Cancer Center: Randomized Phase II Trial of Osimertinib with or without Local Consolidation Therapy (LCT) for Patients with EGFR-mutant Metastatic NSCLC (NORTHSTAR) Pasi A. Jänne, MD, PhD, Dana-Farber/Brigham and Women's Cancer

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Sorafenib in Relapsed AML With FMS-Like Receptor Tyrosine Kinase-3 Internal Tandem Duplication Mutation

Smith Giri, Shadi Hamdeh, Vijaya Raj Bhatt, and James K. Schwarz

consolidation therapy with cytarabine, 0.75 g/m 2 /d for 3 days; idarubicin, 8 mg/m 2 /d for 2 days; and sorafenib, 400 mg twice daily for 28 days. 8 This was complicated by prolonged myelosuppression, sepsis, clostridium difficile infection, weakness, and