and bevacizumab have made a profound difference in progression-free survival (PFS) for patients with ovarian cancer. All patients should have genetic testing and be treated accordingly. The potential for cure is on the horizon,” he added. Dr. O
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Harold J. Burstein
provide confirmatory evidence supporting the original ECOG 2100 study that had led to accelerated approval of bevacizumab in combination with paclitaxel for advanced breast cancer. The FDA will decide in September whether to withdraw the label for the
Deborah K. Armstrong
may be just as effective.” Because median OS was about 30 months in each arm—significantly lower than seen in most GOG trials—the benefit of neoadjuvant chemotherapy is being further studied in randomized trials. Optimal Use of Bevacizumab in the
Katherine Van Loon and Alan P. Venook
1 ECOG 5202 was a randomized phase III study of oxaliplatin and 5-FU/leucovorin with or without bevacizumab for the treatment of patients who had undergone surgery for stage II colon cancer, stratified according to MSI status and 18q
Charles J. Gomer
improve results with PDT, hypothesized Dr. Gomer. He shared his results with bevacizumab (Avastin), a VEGF inhibitor, in combination with PDT in a Kapsoi sarcoma tumor model. 4 Gomer and Ferrario 4 found that combining PDT with bevacizumab resulted in a
NCCN Guidelines for Breast Cancer Updated; Bevacizumab Recommendation Affirmed The National Comprehensive Cancer Network (NCCN) recently updated the NCCN Clinical Practice Guidelines for Oncology (NCCN Guidelines) for Breast Cancer to affirm
Axel Grothey
. Patients should be tested for all RAS mutations to identify patients who will benefit from anti-EGFR agents. Chemotherapy plus either bevacizumab or EGFR antibodies are both viable options as first-line therapy in patients with RAS wild-type mutations
Deborah K. Armstrong, Ronald D. Alvarez, Jamie N. Bakkum-Gamez, Lisa Barroilhet, Kian Behbakht, Andrew Berchuck, Lee-may Chen, Mihaela Cristea, Maria DeRosa, Eric L. Eisenhauer, David M. Gershenson, Heidi J. Gray, Rachel Grisham, Ardeshir Hakam, Angela Jain, Amer Karam, Gottfried E. Konecny, Charles A. Leath III, Joyce Liu, Haider Mahdi, Lainie Martin, Daniela Matei, Michael McHale, Karen McLean, David S. Miller, David M. O’Malley, Sanja Percac-Lima, Elena Ratner, Steven W. Remmenga, Roberto Vargas, Theresa L. Werner, Emese Zsiros, Jennifer L. Burns, and Anita M. Engh
cancers: platinum-based intravenous chemotherapy, platinum-based IV/IP chemotherapy, and platinum-based IP chemotherapy plus bevacizumab, as outlined in Table 2 . Specific options and supporting data for each of these categories of treatment are described
Ganessan Kichenadasse, John O. Miners, Arduino A. Mangoni, Christos S. Karapetis, Ashley M. Hopkins, and Michael J. Sorich
leucovorin. Concomitant vascular endothelial growth factor receptor inhibitor (VEGFi) therapies administered were bevacizumab (BEV) or ramucirumab (RAM), depending on the trial. Concomitant PPIs used were esomeprazole, lansoprazole, omeprazole, pantoprazole
David S. Ettinger, Douglas E. Wood, Wallace Akerley, Lyudmila A. Bazhenova, Hossein Borghaei, David Ross Camidge, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Thomas Dilling, Michael Dobelbower, Ramaswamy Govindan, Mark Hennon, Leora Horn, Thierry M. Jahan, Ritsuko Komaki, Rudy P. Lackner, Michael Lanuti, Rogerio Lilenbaum, Jules Lin, Billy W. Loo Jr, Renato Martins, Gregory A. Otterson, Jyoti D. Patel, Katherine M. Pisters, Karen Reckamp, Gregory J. Riely, Steven E. Schild, Theresa A. Shapiro, Neelesh Sharma, Scott J. Swanson, James Stevenson, Kurt Tauer, Stephen C. Yang, Kristina Gregory, and Miranda Hughes
bevacizumab/cisplatin/pemetrexed, which is only recommended for patients with unresectable disease and should only be considered for patients who are candidates to receive bevacizumab. 47 For patients with clinical stage IV MPM, sarcomatoid histology, or
