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Advances in Immunotherapy for Metastatic Merkel Cell Carcinoma: A Clinician's Guide

Kelly G. Paulson and Shailender Bhatia

reported to be associated with organ rejection and death. 51 For autoimmune disease, a systematic review collated the effects of ICI therapy in 123 patients and found that 75% of patients with autoimmune disease developed flare of autoimmune disease and

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NCCN Guidelines® Insights: Head and Neck Cancers, Version 1.2022

Featured Updates to the NCCN Guidelines

Jimmy J. Caudell, Maura L. Gillison, Ellie Maghami, Sharon Spencer, David G. Pfister, Douglas Adkins, Andrew C. Birkeland, David M. Brizel, Paul M. Busse, Anthony J. Cmelak, A. Dimitrios Colevas, David W. Eisele, Thomas Galloway, Jessica L. Geiger, Robert I. Haddad, Wesley L. Hicks Jr, Ying J. Hitchcock, Antonio Jimeno, Debra Leizman, Loren K. Mell, Bharat B. Mittal, Harlan A. Pinto, James W. Rocco, Cristina P. Rodriguez, Panayiotis S. Savvides, David Schwartz, Jatin P. Shah, David Sher, Maie St. John, Randal S. Weber, Gregory Weinstein, Frank Worden, Justine Yang Bruce, Sue S. Yom, Weining Zhen, Jennifer L. Burns, and Susan D. Darlow

certificate of participation. To participate in this journal CE activity: (1) review the educational content; (2) take the posttest with a 66% minimum passing score and complete the evaluation at https://education.nccn.org/node/91074 ; and (3) view

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Diagnostic Strategies for Invasive Fungal Infections in Patients With Hematologic Malignancies and Hematopoietic Stem Cell Transplant Recipients

Maxim Norkin and John R. Wingard

specimens other than serum specimens . Clin Infect Dis 2004 ; 39 : 1467 – 1474 . 52. Guo YL Chen YQ Wang K . Accuracy of BAL galactomannan in diagnosing invasive aspergillosis: a bivariate metaanalysis and systematic review . Chest 2010

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Role of Prophylactic Cranial Irradiation in Extensive-Stage Small Cell Lung Cancer

Nathan Y. Yu, Terence T. Sio, Vinicius Ernani, Panayiotis Savvides, and Steven E. Schild

, 3 Additionally, SCLC can present with multiple or diffuse CNS metastases. 4 PCI has been used since the 1970s to decrease the rate of intracranial failure for patients with SCLC. 5 This review examines the data and controversy surrounding PCI for

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NCCN Task Force: Clinical Utility of PET in a Variety of Tumor Types

Donald A. Podoloff, Douglas W. Ball, Edgar Ben-Josef, Al B. Benson III, Steven J. Cohen, R. Edward Coleman, Dominique Delbeke, Maria Ho, David H. Ilson, Gregory P. Kalemkerian, Richard J. Lee, Jay S. Loeffler, Homer A. Macapinlac, Robert J. Morgan Jr., Barry Alan Siegel, Seema Singhal, Douglas S. Tyler, and Richard J. Wong

tomography using 2-deoxy-2-fluoro[18F]-D-glucose . Cancer 1998 ; 82 : 2227 – 2234 . 18 Vansteenkiste J Fischer BM Dooms C Mortensen J . Positron-emission tomography in prognostic and therapeutic assessment of lung cancer: systematic review

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Management of Advanced-Phase Chronic Myelogenous Leukemia

Jerald P. Radich

chronic-phase CML, but the same cannot be said for those with advanced disease. Although no specific drug treatment has been recommended for these patients, Dr. Radich briefly reviewed some of the data on the use of TKIs for those in accelerated phase and

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Perioperative Systemic Therapy for Resectable Non–Small Cell Lung Cancer

Bharathi Muthusamy, Pradnya D. Patil, and Nathan A. Pennell

using these treatment modalities in curable early-stage NSCLC. This review outlines the important studies and data regarding neoadjuvant and adjuvant systemic therapies and highlights some ongoing trials. Perioperative Chemotherapy Since the

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Controversies in the Surgical Management of Gastric Cancer

David A. Kooby and Daniel G. Coit

results . Ann Surg 1974 ; 180 : 252 – 256 . 6 Paolini A Tosato F Cassese M . Total gastrectomy in the treatment of adenocarcinoma of the cardia: Review of the results in 73 resected patients . Am J Surg 1986 ; 151 : 238 – 243 . 7

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An Update on Biochemotherapy of Advanced Gastric and Gastroesophageal Adenocarcinoma

Peyman Haghighat and Tanios Bekaii-Saab

1999 ; 80 : 269 – 272 . 14. Wagner AD Grothe W Behl S . Chemotherapy for advanced gastric cancer (review) . Cochrane Database Syst Rev 2005 ; CD004064 . 15. Ridwelski K Gebauer T Fahlke J . Combination chemotherapy with

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Modification and Implementation of NCCN Guidelines™ on Prostate Cancer in the Middle East and North Africa Region

Waleed A. Hassen, Farrok A. Karsan, Farhat Abbas, Yasar Beduk, Ahmed El-Khodary, Marwan Ghosn, Jamal Khader, Raja Khauli, Danny M. Rabah, Ali Shamseddine, and Sandy Srinivas

was to enhance the multidisciplinary approach to the treatment of prostate cancer. The committee, comprising regional experts in the fields of urologic, medical, and radiation oncology, reviewed the 2009 version of the NCCN Guidelines on Prostate