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Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology

Al B. Benson III, Alan P. Venook, Lynette Cederquist, Emily Chan, Yi-Jen Chen, Harry S. Cooper, Dustin Deming, Paul F. Engstrom, Peter C. Enzinger, Alessandro Fichera, Jean L. Grem, Axel Grothey, Howard S. Hochster, Sarah Hoffe, Steven Hunt, Ahmed Kamel, Natalie Kirilcuk, Smitha Krishnamurthi, Wells A. Messersmith, Mary F. Mulcahy, James D. Murphy, Steven Nurkin, Leonard Saltz, Sunil Sharma, David Shibata, John M. Skibber, Constantinos T. Sofocleous, Elena M. Stoffel, Eden Stotsky-Himelfarb, Christopher G. Willett, Christina S. Wu, Kristina M. Gregory, and Deborah Freedman-Cass

trials showed that the addition of bevacizumab to chemotherapy is associated with a higher incidence of treatment-related mortality than chemotherapy alone (relative risk [RR], 1.33; 95% CI, 1.02–1.73; P =.04), with hemorrhage (23.5%), neutropenia (12

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Identification of Targetable ALK Rearrangements in Pancreatic Ductal Adenocarcinoma

Aatur D. Singhi, Siraj M. Ali, Jill Lacy, Andrew Hendifar, Khanh Nguyen, Jamie Koo, Jon H. Chung, Joel Greenbowe, Jeffrey S. Ross, Marina N. Nikiforova, Herbert J. Zeh, Inderpal S. Sarkaria, Anil Dasyam, and Nathan Bahary

and nab-paclitaxel, the patient was started on crizotinib, but experienced neutropenia and was switched to ceritinib. Within 2 months, his CA 19-9 level normalized (23.5 U/mL; Figure 3A ). Moreover, there was a decrease in the size of retroperitoneal

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Delayed Recovery and Increased Severity of Paclitaxel-Induced Peripheral Neuropathy in Patients With Diabetes

Pilar de la Morena Barrio, María Ángeles Vicente Conesa, Enrique González-Billalabeitia, Edgar Urrego, Elisa García-Garre, Elena García-Martínez, Marta Zafra Poves, Vicente Vicente, and Francisco Ayala de la Peña

Multivariate Cox Regression Model for PIPN Duration (N=68) that G-CSF administration as a result of neutropenia might be just a surrogate marker of higher paclitaxel toxicity as a result of either genetic individual characteristics, higher paclitaxel

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Systemic Therapy for Advanced Pancreatic Neuroendocrine Tumors: An Update

Diane L. Reidy-Lagunes

of any grade occurred in 23% and 26% of patients receiving sunitinib, respectively. The most common grade 3 or 4 adverse events in this group were neutropenia (12%) and hypertension (10%). Importantly, information regarding the duration of each of

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NCCN Guidelines Insights: Multiple Myeloma, Version 3.2018

Shaji K. Kumar, Natalie S. Callander, Melissa Alsina, Djordje Atanackovic, J. Sybil Biermann, Jorge Castillo, Jason C. Chandler, Caitlin Costello, Matthew Faiman, Henry C. Fung, Kelly Godby, Craig Hofmeister, Leona Holmberg, Sarah Holstein, Carol Ann Huff, Yubin Kang, Adetola Kassim, Michaela Liedtke, Ehsan Malek, Thomas Martin, Vishala T. Neppalli, James Omel, Noopur Raje, Seema Singhal, George Somlo, Keith Stockerl-Goldstein, Donna Weber, Joachim Yahalom, Rashmi Kumar, and Dorothy A. Shead

severe (grade 3 and 4) neutropenia, risk of second cancers, and other toxicities, including cost. 24 The NCCN panel notes that the benefits and risks of maintenance therapy with lenalidomide, including the risk secondary cancers, should be discussed with

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Trends in Neoadjuvant Approaches in Pancreatic Cancer

Lingling Du and Andrea Wang-Gillam

days 1 and 8 and S-1, 40 mg/m 2 orally twice daily for 14 days every 21 days for 2 cycles) in the neoadjuvant setting for resectable and BR PDAC. 29 A total of 35 patients received treatment, 19 of whom had clearly resectable disease. Neutropenia

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NCCN Guidelines® Insights: Non–Small Cell Lung Cancer, Version 2.2023

Featured Updates to the NCCN Guidelines

David S. Ettinger, Douglas E. Wood, Dara L. Aisner, Wallace Akerley, Jessica R. Bauman, Ankit Bharat, Debora S. Bruno, Joe Y. Chang, Lucian R. Chirieac, Malcolm DeCamp, Thomas J. Dilling, Jonathan Dowell, Gregory A. Durm, Scott Gettinger, Travis E. Grotz, Matthew A. Gubens, Aparna Hegde, Rudy P. Lackner, Michael Lanuti, Jules Lin, Billy W. Loo Jr, Christine M. Lovly, Fabien Maldonado, Erminia Massarelli, Daniel Morgensztern, Thomas Ng, Gregory A. Otterson, Sandip P. Patel, Tejas Patil, Patricio M. Polanco, Gregory J. Riely, Jonathan Riess, Steven E. Schild, Theresa A. Shapiro, Aditi P. Singh, James Stevenson, Alda Tam, Tawee Tanvetyanon, Jane Yanagawa, Stephen C. Yang, Edwin Yau, Kristina M. Gregory, and Miranda Hughes

were not predictive of survival. Grade 3 or worse treatment-related adverse events were reported in 30% (14/46) of patients; the most common events were increased lipase and febrile neutropenia (7% [3/46] for both). 22 None of the adverse events were

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Rates of Menstrual History-Taking and Counseling With Anticancer Treatments Are Low: People Who Menstruate Deserve Gender-Specific Cancer Care

Verity Chadwick, Michaela Kim, Georgia Mills, Catherine Tang, Antoinette Anazodo, Rachel Dear, Rachael Rodgers, Orly Lavee, Samuel Milliken, Georgia McCaughan, John Moore, Barbara Withers, and Nada Hamad

, increases infection risk in immunosuppressed patients with associated neutropenia, 6 and potentiates iron deficiency, anemia, and thrombocytopenia, necessitating transfusion. 8 There is conflicting evidence regarding the link between biochemical markers of

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Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology

Jaffer A. Ajani, Thomas A. D’Amico, David J. Bentrem, David Cooke, Carlos Corvera, Prajnan Das, Peter C. Enzinger, Thomas Enzler, Farhood Farjah, Hans Gerdes, Michael Gibson, Patrick Grierson, Wayne L. Hofstetter, David H. Ilson, Shadia Jalal, Rajesh N. Keswani, Sunnie Kim, Lawrence R. Kleinberg, Samuel Klempner, Jill Lacy, Frank Licciardi, Quan P. Ly, Kristina A. Matkowskyj, Michael McNamara, Aaron Miller, Sarbajit Mukherjee, Mary F. Mulcahy, Darryl Outlaw, Kyle A. Perry, Jose Pimiento, George A. Poultsides, Scott Reznik, Robert E. Roses, Vivian E. Strong, Stacey Su, Hanlin L. Wang, Georgia Wiesner, Christopher G. Willett, Danny Yakoub, Harry Yoon, Nicole R. McMillian, and Lenora A. Pluchino

docetaxel-based chemotherapy. 140 In this study, the ORR was 22.8% and median PFS and OS were 3.8 and 6.2 months, respectively. The most common grade 3–4 toxicities were neutropenia (28.5%) and diarrhea (14.5%). The trifluridine and tipiracil regimen was

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Healthcare Utilization and End-of-Life Outcomes in Patients Receiving CAR T-Cell Therapy

P. Connor Johnson, Caron Jacobson, Alisha Yi, Anna Saucier, Tejaswini M. Dhawale, Ashley Nelson, Mitchell W. Lavoie, Mathew J. Reynolds, Carlisle E.W. Topping, Matthew J. Frigault, and Areej El-Jawahri

determine reasons for hospital readmissions. 12 In the schema for our study, these reasons included symptoms, fever without a source, febrile neutropenia, confirmed infection, dehydration/electrolyte abnormalities, planned hospitalization