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improved efficiency and confidence for investigators. Clinical Oncology AB2016-7. Effect of Oncotype DX Recurrence Score and Recurrence Score-Pathology-Clinical Score on Management Decisions in Early-Stage Breast Cancer Jincy Clement, MD a

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Hyung L. Kim, Marvin R. Puymon, Maochun Qin, Khurshid Guru, and James L. Mohler

products discussed in the article or their competitors. References 1. Jemal A Siegel R Ward E . Cancer statistics, 2008 . CA Cancer J Clin 2008 ; 58 : 71 – 96 . 2. Yatani R Chigusa I Akazaki K . Geographic pathology of latent

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Presenters: Valencia D. Thomas, Michael K. Wong, and Andrew J. Bishop

finger. Pathology demonstrated an MCC measuring approximately 5 mm with 2 mm of invasion. There seemed to be evidence of vascular invasion and positive margins. Systemic workup was negative for metastatic disease. A wide local excision with a sentinel

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Sanjeev Kumar Gupta, Nitin Jain, Guilin Tang, Andrew Futreal, Sa A. Wang, Joseph D. Khoury, Richard K. Yang, Hong Fang, Keyur P. Patel, Rajyalakshmi Luthra, Mark Routbort, Bedia A. Barkoh, Wei Chen, Xizeng Mao, Jianhua Zhang, L. Jeffrey Medeiros, Carlos E. Bueso-Ramos, and Sanam Loghavi

initiated with a clinical consideration of acute leukemia in view of the short symptomatic history and pathology report from another institution indicating a “packed” bone marrow. Physical examination of the patient showed splenomegaly. Renal function, liver

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Margaret von Mehren, R. Lor Randall, Robert S. Benjamin, Sarah Boles, Marilyn M. Bui, Ernest U. Conrad III, Kristen N. Ganjoo, Suzanne George, Ricardo J. Gonzalez, Martin J. Heslin, John M. Kane III, Henry Koon, Joel Mayerson, Martin McCarter, Sean V. McGarry, Christian Meyer, Richard J. O'Donnell, Alberto S. Pappo, I. Benjamin Paz, Ivy A. Petersen, John D. Pfeifer, Richard F. Riedel, Scott Schuetze, Karen D. Schupak, Herbert S. Schwartz, William D. Tap, Jeffrey D. Wayne, Mary Anne Bergman, and Jillian Scavone

desmoid tumors (aggressive fibromatoses). Pathology of STS Biopsy A pretreatment biopsy is highly preferred for the diagnosis and grading of STS and should be performed by an experienced surgeon or radiologist. Biopsy should establish the

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Yong Li, Xian Chen, Yanchun Qu, Jia-Ming Fan, Yan Li, Hui Peng, Yaojie Zheng, Yihong Zhang, and Hai-Bo Zhang

.1097/PAS.0000000000000404 25723109 11. Jo VY , Fletcher CD . WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition . Pathology 2014 ; 46 : 95 – 104 . 24378391 10.1097/PAT.0000000000000050 12. Robinson DR , Wu YM

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James M. Cleary, Scott Rodig, Paul M. Barr, Atul B. Shinagare, Jeffrey W. Clark, Geoffrey I. Shapiro, and Philippe Armand

presented with lymphadenopathy and right arm edema. Pathology revealed anaplastic large cell lymphoma. Immunohistochemistry was positive for ALK1 and fluorescence in situ hybridization analysis demonstrated a t(2;5) chromosomal translocation. The patient

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William J. Gradishar, Benjamin O. Anderson, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, Daniel F. Hayes, Clifford A. Hudis, Steven J. Isakoff, Britt-Marie E. Ljung, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Robert S. Miller, Mark Pegram, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Mary Lou Smith, Hatem Soliman, George Somlo, John H. Ward, Antonio C. Wolff, Richard Zellars, Dorothy A. Shead, and Rashmi Kumar

Pathology Assessment A central component of breast cancer treatment is full knowledge of disease extent and biologic features. These factors contribute to the determination of disease stage, assist in estimating the risk of cancer recurrence, and provide

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Brigette A. Davis, Jenerius A. Aminawung, Maysa M. Abu-Khalaf, Suzanne B. Evans, Kevin Su, Rajni Mehta, Shi-Yi Wang, and Cary P. Gross

aspects of population-based cancer epidemiology studies. All hospitals and private pathology laboratories in Connecticut are required by law to report cancer cases to the CTR. We used CTR data located in the Connecticut Department of Public Health on

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Rodrigo Goncalves and Ron Bose

of the studies on PAM50 use quantitative RT-PCR, but this test has been implemented on the nanotechnology-based nCounter digital gene expression platform, 17 which allows it to be performed in any pathology laboratory. PAM50 measures expression of 50