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Local Treatment of Malignant Brain Tumors Using Implantable Chemotherapeutic Polymers

Gary L. Gallia, Steven Brem, and Henry Brem

biocompatibility of a biodegradable, controlled-release polymer in rats . J Biomed Mater Res 1989 ; 23 : 253 – 266 . 10 Fung LK Ewend MG Sills A . Pharmacokinetics of interstitial delivery of carmustine, 4-hydroperoxycyclophosphamide, and paclitaxel

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Resurrection of PARP Inhibitors in Breast Cancer

Tomas G. Lyons and Mark E. Robson

study of single-agent veliparib showed a PFS of 5.2 months, with a response rate of 14% and 36% for patients with BRCA1 and BRCA2 mutations, respectively. 25 Results of combining veliparib with carboplatin and paclitaxel in the randomized phase II

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Response to Targeted Therapy in BRAF Mutant Anaplastic Thyroid Cancer

Rishi Agarwal, Jiang Wang, Keith Wilson, William Barrett, and John C. Morris

chemotherapy agents, including bleomycin, carboplatin, cisplatin, docetaxel, doxorubicin, and paclitaxel, used in various combinations, have been reported to have palliative benefit in small nonrandomized trials, but little impact on survival. 1 , 3 , 4 As a

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Breast Cancer, Version 3.2013

Richard L. Theriault, Robert W. Carlson, Craig Allred, Benjamin O. Anderson, Harold J. Burstein, Stephen B. Edge, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, William J. Gradishar, Daniel F. Hayes, Clifford A. Hudis, Steven J. Isakoff, Britt-Marie E. Ljung, David A. Mankoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Lori J. Pierce, Elizabeth C. Reed, Lee S. Schwartzberg, Mary Lou Smith, Hatem Soliman, George Somlo, John H. Ward, Antonio C. Wolff, Richard Zellars, Dorothy A. Shead, and Rashmi Kumar

together with other active cytotoxics, such as paclitaxel and vinorelbine 14 , 15 ( identifier: NCT01276041). Phase III trials of pertuzumab plus chemotherapy without trastuzumab have not been reported. Pertuzumab has antitumor

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Durable Complete Response With Immune Checkpoint Inhibitor in Breast Cancer With High Tumor Mutational Burden and APOBEC Signature

Saranya Chumsri, Ethan S. Sokol, Aixa E. Soyano-Muller, Ricardo D. Parrondo, Gina A. Reynolds, Aziza Nassar, and E. Aubrey Thompson

doxorubicin and cyclophosphamide every 2 weeks for 4 cycles followed by weekly paclitaxel for 12 weeks. Follow-up CT of the chest, abdomen, and pelvis after neoadjuvant chemotherapy showed a partial response with no evidence of distant metastases. The patient

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Bevacizumab for Recurrent Glioblastoma Multiforme: A Meta-Analysis

Eric T. Wong, Shiva Gautam, Christopher Malchow, Melody Lun, Edward Pan, and Steven Brem

significant. 11 In metastatic non–small cell lung cancer, the benefit of bevacizumab at 15 mg/kg every 3 weeks was only slightly higher than at a lower dose of 7.5 mg/kg when both drugs were combined with carboplatin and paclitaxel. 12 The higher bevacizumab

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First-Line Treatment of Widely Metastatic BRAF-Mutated Salivary Duct Carcinoma With Combined BRAF and MEK Inhibition

Victor T.G. Lin, Lisle M. Nabell, Sharon A. Spencer, William R. Carroll, Shuko Harada, and Eddy S. Yang

benefit to treatment with combined carboplatin and paclitaxel. 6 Notably, this cohort of 18 patients was established from a retrospective review of >8 years of clinical records, which exemplifies the difficulty of performing robust prospective clinical

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NCCN Guidelines Updates: Breast Cancer

Melinda L. Telli, William J. Gradishar, and John H. Ward

well. In IMpassion130, patients with triple-negative breast cancer were randomized to receive albumen-bound (nab) paclitaxel alone or with atezolizumab in the first-line setting. Among PD-L1–positive patients, progression-free survival improved from 5

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Thymic Malignancies*

David S. Ettinger, Wallace Akerley, Gerold Bepler, Matthew G. Blum, Andrew Chang, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Todd L. Demmy, Ramaswamy Govindan, Frederic W. Grannis Jr., Thierry Jahan, David H. Johnson, Anne Kessinger, Ritsuko Komaki, Feng-Ming Kong, Mark G. Kris, Lee M. Krug, Quynh-Thu Le, Inga T. Lennes, Renato Martins, Janis O'Malley, Raymond U. Osarogiagbon, Gregory A. Otterson, Jyoti D. Patel, Katherine M. Pisters, Karen Reckamp, Gregory J. Riely, Eric Rohren, Scott J. Swanson, Douglas E. Wood, and Stephen C. Yang

treatment for advanced invasive thymoma with cisplatin, doxorubicin, and methylprednisolone . J Thorac Oncol 2007 ; 2 : 73 – 78 . 31. Lemma GL Loehrer PJ Sr Lee JW . A phase II study of carboplatin plus paclitaxel in advanced thymoma or thymic

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Sequencing Therapy for Patients With Lung Cancer

Presented by: Gregory J. Riely

<1%), the hazard ratio for OS was 0.59.” Pembrolizumab is not the only immunotherapy drug to demonstrate value when given in combination with chemotherapy. The addition of atezolizumab to carboplatin/paclitaxel/bevacizumab also demonstrated a