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Personalized Medicine and Oncology Practice Guidelines: A Case Study of Contemporary Biomarkers in Colorectal Cancer

Robin K. Kelley, Stephanie L. Van Bebber, Kathryn A. Phillips, and Alan P. Venook

policy makers. 14 – 22 Guideline adherence has been associated with improved outcomes in some studies. 14 , 15 , 18 , 23 Worldwide, multiple cancer organizations produce practice guidelines. In the United States, ASCO, NCI, and NCCN publish clinical

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Venous Thromboembolic Disease

Duke Comprehensive Cancer Center

Venous thromboembolic disease is a common and life-threatening condition in cancer patients. Results from a recent retrospective study of 66,106 hospitalized adult neutropenic cancer patients showed that 2.74% to 12.10% of these patients, depending on the type of malignancy, experienced a venous thromboembolism (VTE) during first hospitalization. These guidelines specifically outline strategies to prevent and treat VTE in adult inpatients with either a diagnosis of cancer or for whom cancer is clinically suspected. These guidelines evaluate the therapeutic advantages of implementing pharmacologic anticoagulation measures based on both the perceived risk for bleeding (i.e., contraindications to anticoagulation) and the status of the cancer.

For the most recent version of the guidelines, please visit NCCN.org

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Current Concepts in Penile Cancer

Philippe E. Spiess, Simon Horenblas, Lance C. Pagliaro, Matthew C. Biagioli, Juanita Crook, Peter E. Clark, Richard E. Greenberg, and Cesar E. Ercole

NCCN: Continuing Education Accreditation Statement This activity has been designated to meet the educational needs of physicians and nurses involved in the management of patients with cancer. There is no fee for this article. No commercial

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Breast Cancer Version 2.2015

William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J. Goldstein, Clifford A. Hudis, Steven J. Isakoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena Moran, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead, and Rashmi Kumar

appropriate. All recommendations are category 2A unless otherwise noted. Clinical trials: NCCN believes that the best management for any cancer patient is in a clinical trial. Participation in clinical trials is especially encouraged. Overview The

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Cervical Cancer, Version 2.2015

Wui-Jin Koh, Benjamin E. Greer, Nadeem R. Abu-Rustum, Sachin M. Apte, Susana M. Campos, Kathleen R. Cho, Christina Chu, David Cohn, Marta Ann Crispens, Oliver Dorigo, Patricia J. Eifel, Christine M. Fisher, Peter Frederick, David K. Gaffney, Ernest Han, Warner K. Huh, John R. Lurain III, David Mutch, Amanda Nickles Fader, Steven W. Remmenga, R. Kevin Reynolds, Nelson Teng, Todd Tillmanns, Fidel A. Valea, Catheryn M. Yashar, Nicole R. McMillian, and Jillian L. Scavone

NCCN: Continuing Education Accreditation Statement This activity is designated to meet the educational needs of physicians, nurses, and pharmacists involved in the management of patients with cancer. There is no fee for this article. The

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Trimodality Bladder Preservation Therapy for Muscle-Invasive Bladder Cancer

Ronald C. Chen, William U. Shipley, Jason A. Efstathiou, and Anthony L. Zietman

Bladder cancer is the sixth most common cancer in the United States, with approximately 73,510 patients diagnosed and 14,800 dying of the disease in 2012. 1 When the cancer invades into or beyond the muscularis propria (muscle-invasive bladder

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Distress Management

Fox Chase Cancer Center

All patients experience some level of distress at various stages of the diagnosis and treatment of cancer. Physicians' ability to recognize patients' distress has become more challenging as cancer care has shifted to the ambulatory setting, where visits are often short and rushed. Therefore, using clinical practice guidelines for managing psychosocial distress in cancer patients is critical. These guidelines recommend that each new patient be rapidly assessed in the office or clinic waiting room for evidence of distress.

For the most recent version of the guidelines, please visit NCCN.org

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Challenges in the Management of Older Patients With Colon Cancer

Efrat Dotan, Ilene Browner, Arti Hurria, and Crystal Denlinger

the joint sponsorship of Medscape, LLC and JNCCN – The Journal of the National Comprehensive Cancer Network . Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians. Medscape, LLC designates this Journal

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Use of 18F-FDG PET/CT as an Initial Staging Procedure for Stage II–III Breast Cancer: A Multicenter Value Analysis

Colby J. Hyland, Flora Varghese, Christina Yau, Heather Beckwith, Katia Khoury, William Varnado, Gillian L. Hirst, Robert R. Flavell, A. Jo Chien, Douglas Yee, Claudine J. Isaacs, Andres Forero-Torres, Laura J. Esserman, and Michelle E. Melisko

Background Breast cancer accounts for 30% of new cancer diagnoses in women, with approximately 276,480 new invasive breast cancers expected in the United States in 2020. 1 The likelihood of metastatic disease at presentation is stage

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Modern Staging of Small Cell Lung Cancer

Gregory P. Kalemkerian and Shirish M. Gadgeel

NCCN: Continuing Education Accreditation Statement This activity has been designated to meet the educational needs of physicians and nurses involved in the management of patients with cancer. There is no fee for this article. No commercial