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Lauren Nye, Timothy K. Huyck, and William J. Gradishar

. Pathology showed a grade 3 invasive ductal carcinoma of the right breast. Hormonal studies showed a tumor staining positive for estrogen receptors (70%) and progesterone receptors (80%). Her-2/neu was negative at 0%. Ki-67 was 60%. Axillary lymph node biopsy

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Paul F. Engstrom, Mara G. Bloom, George Daniel Demetri, Phillip G. Febbo, William Goeckeler, Marc Ladanyi, Bryan Loy, Kate Murphy, Michael Nerenberg, Paul Papagni, Mark Robson, Robert W. Sweetman, Sean Tunis, Jessica DeMartino, and Jonathan K. Larsen

Editorial Panel Molecular Pathology Codification Workgroup (MPCW). This group has “proposed codes which address greater than 90% of medically useful molecular testing currently being performed and within the realm of the workgroup's charge. The services

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Lin-Chi Chen, William D. Travis, and Lee M. Krug

proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical, and flow cytometric study of 35 cases . Am J Surg Pathol 1991 ; 15 : 529 – 553 . 4. Travis WD Brambilla E Muller-Hermelink HK . Pathology and

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Francisco Civantos

lesions.) Based on pathology, 49% (n = 22) had squamous cell carcinoma, 29% (n = 13) had severe dysplasia, 20% (n = 9) had carcinoma in situ, and 2% (n = 1) had a verrucous carcinoma. The photosensitizing agent, porfimer sodium (Photofrin), was injected

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Frank C. Detterbeck

been active in many ITMIG committees and workgroups. This community spans all continents (except Antarctica), and includes all specialties active in this space (thoracic surgery, radiation oncology, medical oncology, pathology, neurology, epidemiology

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Julie Teruya-Feldstein

The author has no financial interest, arrangement, or affiliation with the manufacturers of any products discussed in the article or their competitors. References 1 . Jaffe E Harris N Stein H Vardiman J . Pathology and

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Lucas Vieira dos Santos, João Paulo Lima, Kathia Cristina Abdalla, Arinilda Campos Bragagnoli, Florinda Almeida Santos, Alexandre dos Anjos Jácome, and Fabiano Elias Porto

-hematological toxicity during treatment with imatinib in patients with early and late chronic phase chronic myeloid leukemia . Leuk Lymphoma 2008 ; 49 : 2328 – 2332 . 11. Miettinen M Lasota J . Gastrointestinal stromal tumors: pathology and prognosis at

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Justin Lee, Jennifer Axilbund, W. Brian Dalton, Daniel Laheru, Stanley Watkins, David Chu, Karen Cravero, Berry Button, Kelly Kyker-Snowman, Ian Waters, Christopher D. Gocke, Josh Lauring, and Ben Ho Park

circumferential mass around the duodenum. She underwent a pancreaticoduodenectomy (Whipple) procedure, with pathology showing a 3.0-cm moderately to poorly differentiated duodenal adenocarcinoma. Of 28 lymph nodes, 6 were positive for disease. The patient

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Robert W. Carlson, D. Craig Allred, Benjamin O. Anderson, Harold J. Burstein, W. Bradford Carter, Stephen B. Edge, John K. Erban, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, William J. Gradishar, Daniel F. Hayes, Clifford A. Hudis, Britt-Marie Ljung, David A. Mankoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Lori J. Pierce, Elizabeth C. Reed, Jasgit Sachdev, Mary Lou Smith, George Somlo, John H. Ward, Antonio C. Wolff, and Richard Zellars

available online and not published in this issue are sections of the guidelines on noninvasive breast cancer and special considerations in breast cancer. Pathology Assessment A central component of the treatment of breast cancer is full knowledge of

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Paul F. Engstrom, Juan Pablo Arnoletti, Al B. Benson III, Jordan D. Berlin, J. Michael Berry, Yi-Jen Chen, Michael A. Choti, Harry S. Cooper, Raza A. Dilawari, Dayna S. Early, Peter C. Enzinger, Marwan G. Fakih, James Fleshman Jr., Charles Fuchs, Jean L. Grem, James A. Knol, Lucille A. Leong, Edward Lin, Mary F. Mulcahy, Eric Rohren, David P. Ryan, Leonard Saltz, David Shibata, John M. Skibber, William Small Jr., Constantinos Sofocleous, James Thomas, Alan P. Venook, and Christopher Willett

persistent infection with a high-risk form of HPV (e.g., HPV-16 or -18) is believed to be strongest. 4 , 6 , 7 For example, a study of tumor specimens from 60 pathology laboratories showed that HPV-16 was detected in 84% and 0% of anal and rectal cancer