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Acute Myeloid Leukemia, Version 2.2013

Margaret R. O’Donnell, Martin S. Tallman, Camille N. Abboud, Jessica K. Altman, Frederick R. Appelbaum, Daniel A. Arber, Eyal Attar, Uma Borate, Steven E. Coutre, Lloyd E. Damon, Jeffrey Lancet, Lori J. Maness, Guido Marcucci, Michael G. Martin, Michael M. Millenson, Joseph O. Moore, Farhad Ravandi, Paul J. Shami, B. Douglas Smith, Richard M. Stone, Stephen A. Strickland, Eunice S. Wang, Kristina M. Gregory, and Maoko Naganuma

evaluated in the LPA 2005 study, outcomes were similar between low- and intermediate-risk groups regarding the 3-year cumulative incidence of relapse (6% for both), disease-free survival (DFS; 93% vs 94%) and overall survival (OS; 96% vs 93%). 10 In the

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NCCN Guidelines Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 2.2019

William G. Wierda, John C. Byrd, Jeremy S. Abramson, Syed F. Bilgrami, Greg Bociek, Danielle Brander, Jennifer Brown, Asher A. Chanan-Khan, Julio C. Chavez, Steve E. Coutre, Randall S. Davis, Christopher D. Fletcher, Brian Hill, Brad S. Kahl, Manali Kamdar, Lawrence D. Kaplan, Nadia Khan, Thomas J. Kipps, Shuo Ma, Sami Malek, Anthony Mato, Claudio Mosse, Vishala T. Neppalli, Mazyar Shadman, Tanya Siddiqi, Deborah Stephens, Nina Wagner, Mary A. Dwyer, and Hema Sundar

patients with heavily pretreated del(17p) CLL, it was less common among a broader group of patients with less heavily pretreated relapsed/refractory CLL. 17 Further study is needed to determine the exact risk profile and mechanism of Richter

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NCCN Guidelines Insights: Chronic Myeloid Leukemia, Version 1.2017

Arnel Pallera, Jessica K. Altman, Ellin Berman, Camille N. Abboud, Bhavana Bhatnagar, Peter Curtin, Daniel J. DeAngelo, Jason Gotlib, R. Tanner Hagelstrom, Gabriela Hobbs, Madan Jagasia, Hagop M. Kantarjian, Patricia Kropf, Leland Metheny, Joseph O. Moore, Evelena Ontiveros, Enkhtsetseg Purev, Albert Quiery, Vishnu V.B. Reddy, Michal G. Rose, Neil P. Shah, B. Douglas Smith, David S. Snyder, Kendra L. Sweet, Raoul Tibes, David T. Yang, Kristina Gregory, Hema Sundar, Michael Deininger, and Jerald P. Radich

50% to 60% among patients who stop TKI therapy after having achieved either a complete molecular response (CMR) or deep molecular response (≥MR4), usually within 6 months of treatment cessation, with some relapses noted as early as 1 month off therapy

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Emerging Role of CAR T Cells in Non-Hodgkin's Lymphoma

Mauro P. Avanzi and Renier J. Brentjens

, relapse and resistance prevent the ultimate goal of achieving cure in all patients. 8 In the past few decades, the introduction of improved chemotherapy regimens, monoclonal antibodies (mAbs), radioimmunotherapy, and targeted adoptive T-cell therapies

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Individualized Approach to Management of Light Chain Amyloidosis

Giovanni Palladini and Paolo Milani

review discusses how available knowledge allows the management of patients with AL amyloidosis to be individualized, from the selection of up-front therapy to the detection and management of refractory and relapsed disease. Selection of Up

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Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology

Shaji K. Kumar, Natalie S. Callander, Kehinde Adekola, Larry D. Anderson Jr, Muhamed Baljevic, Rachid Baz, Erica Campagnaro, Jorge J. Castillo, Caitlin Costello, Christopher D’Angelo, Benjamin Derman, Srinivas Devarakonda, Noura Elsedawy, Alfred Garfall, Kelly Godby, Jens Hillengass, Leona Holmberg, Myo Htut, Carol Ann Huff, Malin Hultcrantz, Yubin Kang, Sarah Larson, Hans Lee, Michaela Liedtke, Thomas Martin, James Omel, Timothy Robinson, Aaron Rosenberg, Douglas Sborov, Mark A. Schroeder, Daniel Sherbenou, Attaya Suvannasankha, Jason Valent, Asya Nina Varshavsky-Yanovsky, Jenna Snedeker, and Rashmi Kumar

-agent therapy for patients with WM until disease progression or unacceptable toxicity. The phase III iNNOVATE trial (n=150) compared both newly diagnosed and patients with relapsed/refractory WM treated with ibrutinib/rituximab or rituximab plus placebo. 48

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Multiple Myeloma

Kenneth C. Anderson, Melissa Alsina, William Bensinger, J. Sybil Biermann, Asher Chanan-Khan, Adam D. Cohen, Steven Devine, Benjamin Djulbegovic, Cristina Gasparetto, Carol Ann Huff, Madan Jagasia, Bruno C. Medeiros, Ruby Meredith, Noopur Raje, Jeffrey Schriber, Seema Singhal, George Somlo, Keith Stockerl-Goldstein, Guido Tricot, Julie M. Vose, Donna Weber, Joachim Yahalom, and Furhan Yunus

risk groups with updated results of a phase I/II study [abstract] . Blood 2008 ; 112 : Abstract 92 . 30 Richardson PG Sonneveld P Schuster MW . Bortezomib or high-dose dexamethasone for relapsed multiple myeloma . N Engl J Med 2005

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Systemic Light Chain Amyloidosis, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology

Shaji K. Kumar, Natalie S. Callander, Kehinde Adekola, Larry D. Anderson Jr., Muhamed Baljevic, Erica Campagnaro, Jorge J. Castillo, Caitlin Costello, Christopher D’Angelo, Srinivas Devarakonda, Noura Elsedawy, Alfred Garfall, Kelly Godby, Jens Hillengass, Leona Holmberg, Myo Htut, Carol Ann Huff, Malin Hultcrantz, Yubin Kang, Sarah Larson, Hans C. Lee, Michaela Liedtke, Thomas Martin, James Omel, Aaron Rosenberg, Douglas Sborov, Jason Valent, Ryan Berardi, and Rashmi Kumar

active as primary treatment as well as for relapsed amyloidosis. 33 – 36 In a study comparing 2 doses of bortezomib, it was seen that bortezomib is well tolerated at doses up to 1.6 mg/m 2 on a once-weekly schedule and 1.3 mg/m 2 on a twice

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Advances in Supportive Care for Multiple Myeloma

Noopur S. Raje, Andrew J. Yee, and G. David Roodman

experiencing a complete response or very good partial response and further continued at relapse. 23 This recommendation is motivated by the finding in the MRC Myeloma IX trial that improvements in overall survival and reduced SREs occurred in patients who

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NCCN Guidelines® Insights: Multiple Myeloma, Version 3.2022

Featured Updates to the NCCN Guidelines

Natalie S. Callander, Muhamed Baljevic, Kehinde Adekola, Larry D. Anderson Jr, Erica Campagnaro, Jorge J. Castillo, Caitlin Costello, Srinivas Devarakonda, Noura Elsedawy, Matthew Faiman, Alfred Garfall, Kelly Godby, Jens Hillengass, Leona Holmberg, Myo Htut, Carol Ann Huff, Malin Hultcrantz, Yubin Kang, Sarah Larson, Michaela Liedtke, Thomas Martin, James Omel, Douglas Sborov, Kenneth Shain, Keith Stockerl-Goldstein, Donna Weber, Ryan A. Berardi, Rashmi Kumar, and Shaji K. Kumar

variety of therapies are available for previously treated MM. The choice of appropriate therapy for a patient depends on the context of the clinical relapse, such as prior treatment, duration of response, the class of agents previously received, and